Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   ACLV65_RS00480 Genome accession   NZ_OZ217342
Coordinates   77009..79162 (+) Length   717 a.a.
NCBI ID   WP_411864249.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis B22     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 72009..84162
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV65_RS00415 (SMIB22_00800) - 72045..72374 (+) 330 WP_411864245.1 hypothetical protein -
  ACLV65_RS00420 (SMIB22_00810) - 72491..73405 (+) 915 WP_173277378.1 hypothetical protein -
  ACLV65_RS00425 (SMIB22_00820) - 73405..73761 (+) 357 WP_411864246.1 DUF6287 domain-containing protein -
  ACLV65_RS00430 (SMIB22_00830) - 74253..74381 (+) 129 WP_000658224.1 smi_0059.1 family bacteriocin-like peptide -
  ACLV65_RS00435 (SMIB22_00840) - 74393..74548 (+) 156 WP_001004584.1 hypothetical protein -
  ACLV65_RS00440 (SMIB22_00850) - 74583..74777 (+) 195 WP_000180815.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  ACLV65_RS00445 (SMIB22_00870) - 75014..75181 (+) 168 WP_346743549.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  ACLV65_RS00450 - 75185..75400 (+) 216 WP_411864247.1 bacteriocin immunity protein -
  ACLV65_RS00455 (SMIB22_00880) - 75481..75660 (+) 180 WP_050219186.1 hypothetical protein -
  ACLV65_RS00460 (SMIB22_00890) - 75738..75944 (+) 207 WP_411864248.1 bacteriocin immunity protein -
  ACLV65_RS00465 (SMIB22_00900) - 75937..76092 (+) 156 WP_000357248.1 smi_0061 family bacteriocin-like peptide -
  ACLV65_RS00470 - 76096..76311 (+) 216 WP_240156702.1 bacteriocin immunity protein -
  ACLV65_RS00475 (SMIB22_00910) - 76392..76571 (+) 180 WP_078353052.1 hypothetical protein -
  ACLV65_RS00480 (SMIB22_00920) comA 77009..79162 (+) 2154 WP_411864249.1 peptide cleavage/export ABC transporter ComA Regulator
  ACLV65_RS00485 (SMIB22_00930) comB 79175..80524 (+) 1350 WP_411864250.1 competence pheromone export protein ComB Regulator
  ACLV65_RS00490 (SMIB22_00940) purC 80695..81402 (+) 708 WP_411864251.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80228.22 Da        Isoelectric Point: 6.3887

>NTDB_id=1170082 ACLV65_RS00480 WP_411864249.1 77009..79162(+) (comA) [Streptococcus mitis isolate S. mitis B22]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDRDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVSYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILDNLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1170082 ACLV65_RS00480 WP_411864249.1 77009..79162(+) (comA) [Streptococcus mitis isolate S. mitis B22]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTACTATTCTTTGGCTCACTTACGAGAATTGGCCAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGGGCCATTAAGGCGGATATGACGCTCTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGAAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAGGGATAG
CATTCATATTGCCGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGCTGAAGAATGGACAGGAG
TGACCCTTTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGATCAAAAGAATGGCCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCGACACTCTTGGTAACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGTTGGGGATTATTTCTATTGGGCTGGTGA
TTGTTTATATTCTTCAGCAGATCTTGTCTTACGCTCAGGAGTATCTCTTACTTGTTTTGGGGCAACGCTTGTCGATTGAT
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTGCCTATGTCCTTTTTTGCGACACGTCGGACAGGGGAAATCGTGTC
TCGTTTTACAGATGCTAACAGTATTATCGATGCGCTAGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCTCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACCTTATTGGCGCTTCCTATCTACACAGTG
ATCATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAATGGTATTGAGACTATCAAGTCTTTGACCAGTGAGAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAAAAATCTTTTACCTATAGTCGGGCAGAGAGTCAGCAAAAGGCTCTGAAAAAAGTTGCCCATCTC
TTGCTCAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAACTTCAGACAGCGCAGGTCG
CCAATAACCGTCTAAATGAGGTTTATCTAGTAGCTTCGGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGAGATGACTTTCAAGCAGGTTTCCTACAAGTATGGCTATGGTCGAGATGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGAATTTCAGGGTCAGGTAAGACGACATTGGCCAAGATGATGGTTAATTTTT
ATGATCCAAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAGGCCCTGCGCCAGTATATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGATAATCTTCTTTTGGGAGCCAAGGAGGGAACGAC
TCAAGAGGATATCTTACGGGCGGTCGAGTTGGCAGAGATTCGGGAGGACATTGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATCTCAGGTGGTCAACGCCAGAGAATTGCTCTGGCGCGTGCTCTCTTGACAGATGCA
CCGGTCTTGATTTTGGACGAGGCGACCAGCAGTTTGGATATTCTGACAGAGAAGCGGATTGTTGACAATCTCATGGCTTT
AGATAAGACCTTGATTTTCATTGCTCACCGCTTGACCATTGCTGAGCGGACAGAGAAGGTGGTTGTTTTGGATCAGGGCA
AGATTGTTGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTGAATAGCTAG

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-650)

ABC transporter transmembrane region (ABC_membrane)

(170-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

99.163

100

0.992
  comA Streptococcus mitis SK321

98.745

100

0.987
  comA Streptococcus pneumoniae Rx1

98.745

100

0.987
  comA Streptococcus pneumoniae D39

98.745

100

0.987
  comA Streptococcus pneumoniae R6

98.745

100

0.987
  comA Streptococcus pneumoniae TIGR4

98.326

100

0.983
  comA Streptococcus gordonii str. Challis substr. CH1

80.474

100

0.805
  comA/nlmT Streptococcus mutans UA159

65.272

100

0.653

Multiple sequence alignment