Detailed information NTG1170039

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: ACLV7Q_RS04265
• Genome accession: NZ_OZ217341
• Coordinates: 855454..856158 (+)
• Length: 234 a.a.
• NCBI ID: WP_050259789.1
• Uniprot ID: A0A0T8U7H7
• Organism: Streptococcus mitis isolate S. mitis C22
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 850454..861158

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7Q_RS04240 (SMIC22_08250)	coaC	850708..851259 (-)	552	WP_218757734.1	phosphopantothenoylcysteine decarboxylase	-
ACLV7Q_RS04245 (SMIC22_08260)	coaB	851271..851960 (-)	690	WP_218757735.1	phosphopantothenate--cysteine ligase	-
ACLV7Q_RS04250 (SMIC22_08270)	-	852193..853863 (+)	1671	WP_218757736.1	formate--tetrahydrofolate ligase	-
ACLV7Q_RS04255 (SMIC22_08280)	-	853985..854137 (-)	153	WP_218757737.1	hypothetical protein	-
ACLV7Q_RS04260 (SMIC22_08290)	mutY	854223..855398 (+)	1176	WP_218757738.1	A/G-specific adenine glycosylase	-
ACLV7Q_RS04265 (SMIC22_08300)	micA	855454..856158 (+)	705	WP_050259789.1	response regulator YycF	Regulator
ACLV7Q_RS04270 (SMIC22_08310)	micB	856151..857500 (+)	1350	WP_176139155.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ACLV7Q_RS04275 (SMIC22_08320)	vicX	857502..858311 (+)	810	WP_054384038.1	MBL fold metallo-hydrolase	Regulator
ACLV7Q_RS04280 (SMIC22_08330)	relB	858402..858644 (+)	243	WP_050223090.1	type II toxin-antitoxin system RelB family antitoxin	-
ACLV7Q_RS04285 (SMIC22_08340)	-	858646..858900 (+)	255	WP_001809704.1	type II toxin-antitoxin system RelE family toxin	-
ACLV7Q_RS04290 (SMIC22_08350)	-	859082..860980 (+)	1899	WP_218757739.1	Eco57I restriction-modification methylase domain-containing protein	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1170039 ACLV7Q_RS04265 WP_050259789.1 855454..856158(+) (micA) [Streptococcus mitis isolate S. mitis C22]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1170039 ACLV7Q_RS04265 WP_050259789.1 855454..856158(+) (micA) [Streptococcus mitis isolate S. mitis C22]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAACGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAGCCAGATATTATTATTTTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCCAAGACCATTCGCAAGACAAGTAGTGTACCTATTATCATGTTGTCGGCT
AAAGACAGTGAATTTGATAAGGTCATCGGTTTGGAGCTTGGGGCTGATGACTATGTAACCAAACCTTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTTTGCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGCAAACCTC
AGCCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAGTTTGAGCTTTTGTATCATTTGGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACGGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A0T8U7H7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	99.573	100	0.996
vicR	Streptococcus mutans UA159	78.97	99.573	0.786
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.913	98.291	0.432
scnR	Streptococcus mutans UA159	37.768	99.573	0.376