Detailed information NTG1170000

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: ACLV7Q_RS00350
• Genome accession: NZ_OZ217341
• Coordinates: 58035..60188 (+)
• Length: 717 a.a.
• NCBI ID: WP_218757515.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis C22
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 53035..65188

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7Q_RS00305 (SMIC22_00560)	-	53361..53507 (+)	147	WP_000425304.1	smi_0057.1 family bacteriocin-like peptide	-
ACLV7Q_RS00310	-	54072..54887 (+)	816	WP_225904721.1	GHKL domain-containing protein	-
ACLV7Q_RS00315 (SMIC22_00580)	-	54884..55615 (+)	732	WP_218757512.1	response regulator transcription factor	-
ACLV7Q_RS00320 (SMIC22_00590)	-	56341..56529 (+)	189	WP_218757513.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ACLV7Q_RS00325 (SMIC22_00600)	-	56550..56717 (+)	168	WP_060805139.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ACLV7Q_RS00330 (SMIC22_00610)	-	56727..56897 (+)	171	WP_218757514.1	hypothetical protein	-
ACLV7Q_RS00335 (SMIC22_00620)	-	56947..57135 (+)	189	WP_218757513.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ACLV7Q_RS00340 (SMIC22_00630)	-	57156..57323 (+)	168	WP_060805139.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ACLV7Q_RS00345 (SMIC22_00640)	-	57688..57876 (+)	189	WP_033680983.1	hypothetical protein	-
ACLV7Q_RS00350 (SMIC22_00650)	comA	58035..60188 (+)	2154	WP_218757515.1	peptide cleavage/export ABC transporter ComA	Regulator
ACLV7Q_RS00355 (SMIC22_00660)	comB	60201..61550 (+)	1350	WP_218757516.1	competence pheromone export protein ComB	Regulator
ACLV7Q_RS00360 (SMIC22_00670)	purC	61826..62533 (+)	708	WP_000043295.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
ACLV7Q_RS00365	-	62535..62678 (+)	144	WP_078353133.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80276.31 Da
• Isoelectric Point: 6.3889

>NTDB_id=1170000 ACLV7Q_RS00350 WP_218757515.1 58035..60188(+) (comA) [Streptococcus mitis isolate S. mitis C22]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMSFKQVYYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=1170000 ACLV7Q_RS00350 WP_218757515.1 58035..60188(+) (comA) [Streptococcus mitis isolate S. mitis C22]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGCTATTATTCTTTGGCTCACTTGCGAGAATTGGCCAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGCTTTGAGACACGAGCTATCAAGGCGGATATGACGCTCTTTGACTTGCCAGATTTG
ACCTTTCCTTTTGTTGCTCATGTGCTTAAGGAAGGAAAATTACTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGCGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGATCAAAAGAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAACATCGTTTTGGCAACACTCTTGGTAACCGTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGCTGGGGATTATTTCTATTGGGCTGGTCA
TCGTCTATATCCTCCAGCAGATTTTGTCTTACGCTCAGGAGTATCTCTTACTTGTTTTGGGGCAACGCTTGTCGATTGAT
GTGATTTTGTCCTATATCAAACATGTTTTTCACCTGCCTATGTCCTTTTTTGCGACACGCAGGACAGGGGAAATCGTGTC
TCGTTTCACGGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTTTTTTTCATGACTTTATTGGCACTTCCTATCTATACAGTG
ATTATCTTTGCTTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCAGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAAAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTTAAAAAAGTTGCCCATCTC
TTGCTCAATGTCGGCATTCTCTGGATGGGAGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTTGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTCG
CCAATAACCGTCTAAACGAGGTTTATCTGGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGAGATGTCCTTCAAGCAGGTTTACTACAAGTATGGTTATGGTCGAGACGTCTTGTCAGATATCAATTTGACTAT
TCCCCAAGGTTCTAAAGTAGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACCTTGGCTAAGATGATGGTTAATTTTT
ACGATCCAAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAGGCCCTGCGCCAGTATATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGGGAGGACATTGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATTGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACCAGCAGTCTGGATATCTTGACTGAGAAGCGAATTGTCGATAATCTCATGGCTTT
AGACAAGACCTTGATTTTCATTGCTCATCGCTTGACCATTGCAGAGCGGACAGAGAAGGTGGTTGTTTTGGATCAGGGCA
AGATTGTTGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTATGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter transmembrane region (ABC_membrane) (170-438)

• ABC transporter (ABC_tran) (500-650)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis SK321	99.303	100	0.993
comA	Streptococcus pneumoniae Rx1	98.884	100	0.989
comA	Streptococcus pneumoniae D39	98.884	100	0.989
comA	Streptococcus pneumoniae R6	98.884	100	0.989
comA	Streptococcus mitis NCTC 12261	98.884	100	0.989
comA	Streptococcus pneumoniae TIGR4	98.466	100	0.985
comA	Streptococcus gordonii str. Challis substr. CH1	80.614	100	0.806
comA/nlmT	Streptococcus mutans UA159	65.132	100	0.651