Detailed information NTG1169956

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: ACLV7H_RS04435
• Genome accession: NZ_OZ217340
• Coordinates: 831980..832654 (+)
• Length: 224 a.a.
• NCBI ID: WP_000590635.1
• Uniprot ID: A0A139R176
• Organism: Streptococcus oralis isolate S. oralis A22
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 826980..837654

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7H_RS04410 (SORA22_08830)	-	827036..829576 (+)	2541	WP_045591605.1	M1 family metallopeptidase	-
ACLV7H_RS04415 (SORA22_08840)	-	829758..830042 (+)	285	WP_008283941.1	helix-turn-helix domain-containing protein	-
ACLV7H_RS04420 (SORA22_08850)	-	830093..830419 (+)	327	WP_411866470.1	DMT family transporter	-
ACLV7H_RS04425 (SORA22_08860)	-	830434..831237 (+)	804	WP_000502735.1	SDR family NAD(P)-dependent oxidoreductase	-
ACLV7H_RS04430 (SORA22_08870)	-	831469..831849 (+)	381	WP_045591600.1	hypothetical protein	-
ACLV7H_RS04435 (SORA22_08880)	ciaR	831980..832654 (+)	675	WP_000590635.1	two-component system response regulator CiaR	Regulator
ACLV7H_RS04440 (SORA22_08890)	ciaH	832644..833981 (+)	1338	WP_045591599.1	sensor histidine kinase	Regulator
ACLV7H_RS04445 (SORA22_08900)	-	834046..834330 (-)	285	WP_045591598.1	DUF3270 domain-containing protein	-
ACLV7H_RS04450 (SORA22_08920)	-	834711..835766 (+)	1056	WP_411866471.1	ABC transporter permease	-
ACLV7H_RS04455 (SORA22_08930)	-	835780..836460 (+)	681	WP_411866472.1	ABC transporter ATP-binding protein	-
ACLV7H_RS04460 (SORA22_08940)	-	836587..837516 (+)	930	WP_411866473.1	peptidase U32 family protein	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25465.26 Da
• Isoelectric Point: 4.2660

>NTDB_id=1169956 ACLV7H_RS04435 WP_000590635.1 831980..832654(+) (ciaR) [Streptococcus oralis isolate S. oralis A22]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDVVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide

• Length: 675 bp

>NTDB_id=1169956 ACLV7H_RS04435 WP_000590635.1 831980..832654(+) (ciaR) [Streptococcus oralis isolate S. oralis A22]
ATGATTAAGATTTTACTAGTAGAAGACGACTTAGGGTTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT
TATGCAGGTTTTTGATGGAGAAGAAGGTCTCTATGAAGCTGAGAGTGGCGTCTATGATTTGATCTTGCTTGACCTGATGT
TGCCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAAGGAATCACGACACCAGTCCTTATCATGACCGCT
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCGGATGACTACCTCACCAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAAGCCCTTCTCAAACGTTCAGGCAAGTTTAATGAAAACACCTTGACCTATGGGGATGTTGTCG
TCAATCTTTCAACGAATGAAGTGAAGGTGGAAGACACGCCTGTGGAACTACTCGGAAAAGAGTTTGAATTGTTGGTTTAC
TTCCTTCAAAATCAAAATGTCATTCTTCCCAAGACACAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACTAT
TTCCGTTGTAGAAGTCTATGTTTCAAAAGTTCGTAAGAAACTGAAGGGTACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A139R176

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae TIGR4	97.321	100	0.973
ciaR	Streptococcus pneumoniae D39	97.321	100	0.973
ciaR	Streptococcus pneumoniae R6	97.321	100	0.973
ciaR	Streptococcus pneumoniae Rx1	97.321	100	0.973
ciaR	Streptococcus mutans UA159	87.5	100	0.875
vicR	Streptococcus mutans UA159	36.481	100	0.379
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366