Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ACLV7H_RS04440 Genome accession   NZ_OZ217340
Coordinates   832644..833981 (+) Length   445 a.a.
NCBI ID   WP_045591599.1    Uniprot ID   A0A0F2D5P4
Organism   Streptococcus oralis isolate S. oralis A22     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 827644..838981
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7H_RS04415 (SORA22_08840) - 829758..830042 (+) 285 WP_008283941.1 helix-turn-helix domain-containing protein -
  ACLV7H_RS04420 (SORA22_08850) - 830093..830419 (+) 327 WP_411866470.1 DMT family transporter -
  ACLV7H_RS04425 (SORA22_08860) - 830434..831237 (+) 804 WP_000502735.1 SDR family NAD(P)-dependent oxidoreductase -
  ACLV7H_RS04430 (SORA22_08870) - 831469..831849 (+) 381 WP_045591600.1 hypothetical protein -
  ACLV7H_RS04435 (SORA22_08880) ciaR 831980..832654 (+) 675 WP_000590635.1 two-component system response regulator CiaR Regulator
  ACLV7H_RS04440 (SORA22_08890) ciaH 832644..833981 (+) 1338 WP_045591599.1 sensor histidine kinase Regulator
  ACLV7H_RS04445 (SORA22_08900) - 834046..834330 (-) 285 WP_045591598.1 DUF3270 domain-containing protein -
  ACLV7H_RS04450 (SORA22_08920) - 834711..835766 (+) 1056 WP_411866471.1 ABC transporter permease -
  ACLV7H_RS04455 (SORA22_08930) - 835780..836460 (+) 681 WP_411866472.1 ABC transporter ATP-binding protein -
  ACLV7H_RS04460 (SORA22_08940) - 836587..837516 (+) 930 WP_411866473.1 peptidase U32 family protein -
  ACLV7H_RS04465 (SORA22_08950) rpiA 837622..838305 (+) 684 WP_411866474.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50819.52 Da        Isoelectric Point: 9.6796

>NTDB_id=1169957 ACLV7H_RS04440 WP_045591599.1 832644..833981(+) (ciaH) [Streptococcus oralis isolate S. oralis A22]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADASKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSFSASSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPDIAEVSPQFFKTTFANYELIASENDRVFNYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLTVTDNGIGISATDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPPKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=1169957 ACLV7H_RS04440 WP_045591599.1 832644..833981(+) (ciaH) [Streptococcus oralis isolate S. oralis A22]
ATGTTCAATAAACTAAAAAAAACATGGTACGCGGATGATTTCAGCTATTTCATTCGAAACTTCGGGGTGTTCACCTTGAT
TTTCTCTGCTATGACCTTGATTATCCTTCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTACAAGCCC
TTAGTAGTAGTCCTCAAGCGGTCATCCAGTTAGCCCTGAATCGAGCAACTGAGGAAGTCAAGGATATTCAACCAGCAACA
GCGGATGCCAGCAAGGCTGAAATCAAGCCCAATGTTAGCTCCAATACAGAAGTCTTGCTCTTTGACAAGGATTTTAACCA
ACTCTTACTGGGCAATCGCTTTTTAGGCTTGGATAAGATCAAGCTGGACAAGAAAGAGTTGAATCATATTCGCCAAATCC
AAGTTGTCAATAGCTACGGTCAGGAAGAAACCTACCGAATGATCTTGATGGAAACTAACTCTTTCTCCGCATCAAGCAAT
GTCAAATATGCGGCGGTTTTAATCAATACCAGCCAGCTTGAACAAATCAGCCAAAACCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTGTCTTTAATCGCCAGTGTTTACCTAGCACGTGTCAGTGTCAAACCCTTGCTGGAAAGTA
TGCAAAAGCAGAAGTCTTTTGTTGAAAATGCGAGCCACGAACTGAGAACACCTTTGGCCGTTTTACAAAATCGTTTAGAG
AATCTCTTTCGAAAACCAGAGGCAACAATCATGGAATCCAGCGAAAGTATCGCTTCCAGTCTTGAAGAGGTTCGCAACAT
GCGTTTCCTCACGACCAATCTTCTCAACCTTGCACGTCGAGATGATGGAATCAAACCAGATATAGCAGAAGTTTCTCCAC
AATTCTTTAAAACAACCTTTGCCAACTATGAGTTAATTGCTTCTGAAAATGATCGTGTTTTCAACTATGAAAATCGGATT
TATCGTCCCTTTATGACCGATCAGTTGCTCTTAAAACAACTCATGACCATCTTGTTTGATAATGCCATCAAGTATACCGA
AGAAGATGGGAAAATTGAGTTTGTAGTCCATGCTACAGATCGCCACCTCTATCTTACAGTAACGGATAATGGAATCGGAA
TCTCAGCTACTGACAAGAAGAAAATCTTTGACCGTTTTTACCGTGTAGACAAGGCAAGGACTCGTCAGAAAGGTGGCTTT
GGTTTGGGACTTTCGTTGGCCAAGCAGATTGTTGATGCTTTGCGAGGAACAATTAGCGTGAAAGATAACAAACCTAGAGG
AACGATTTTTGAAGTTAAGATTGCCATCCAATCTCCTCCAAAACGAAAGAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F2D5P4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.521

99.551

0.831
  ciaH Streptococcus pneumoniae D39

83.521

99.551

0.831
  ciaH Streptococcus pneumoniae R6

83.521

99.551

0.831
  ciaH Streptococcus pneumoniae TIGR4

83.521

99.551

0.831
  ciaH Streptococcus mutans UA159

54.795

98.427

0.539

Multiple sequence alignment