Detailed information NTG1161718

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: U8955_RS04135
• Genome accession: NZ_OY769914
• Coordinates: 815881..816555 (+)
• Length: 224 a.a.
• NCBI ID: WP_000590630.1
• Uniprot ID: A0A4V0BT06
• Organism: Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 810881..821555

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U8955_RS04110 (SDENT7746_04130)	-	811170..811670 (+)	501	WP_000403619.1	NUDIX hydrolase	-
U8955_RS04115 (SDENT7746_04135)	-	811648..812007 (+)	360	WP_000800853.1	hypothetical protein	-
U8955_RS04120 (SDENT7746_04140)	-	812041..812637 (+)	597	WP_001101063.1	DUF6707 family protein	-
U8955_RS04125 (SDENT7746_04145)	-	812662..813102 (+)	441	WP_000188803.1	ASCH domain-containing protein	-
U8955_RS04130 (SDENT7746_04150)	-	813225..815771 (+)	2547	WP_001149137.1	M1 family metallopeptidase	-
U8955_RS04135 (SDENT7746_04155)	ciaR	815881..816555 (+)	675	WP_000590630.1	two-component system response regulator CiaR	Regulator
U8955_RS04140 (SDENT7746_04160)	ciaH	816545..817882 (+)	1338	WP_000482352.1	sensor histidine kinase	Regulator
U8955_RS04145 (SDENT7746_04165)	-	817947..818231 (-)	285	WP_001111509.1	DUF3270 domain-containing protein	-
U8955_RS04150 (SDENT7746_04170)	-	818617..819672 (+)	1056	WP_000280274.1	ABC transporter permease	-
U8955_RS04155 (SDENT7746_04175)	-	819686..820366 (+)	681	WP_000125736.1	ABC transporter ATP-binding protein	-
U8955_RS04160 (SDENT7746_04180)	-	820492..821421 (+)	930	WP_038805085.1	peptidase U32 family protein	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25479.29 Da
• Isoelectric Point: 4.2660

>NTDB_id=1161718 U8955_RS04135 WP_000590630.1 815881..816555(+) (ciaR) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide

• Length: 675 bp

>NTDB_id=1161718 U8955_RS04135 WP_000590630.1 815881..816555(+) (ciaR) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGATAAAAATCTTATTAGTAGAAGATGACCTAGGTCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCTGATGT
CATGCAGGTCTTTGATGGTGAAGAAGGACTTTACGAAGCTGAGAGTGGCGTTTATGACTTGATTCTGCTTGACCTCATGT
TGCCTGAAAAAAATGGCTTCCAAGTTTTGAAAGAATTGCGTGAAAAAGGAATTACAACCCCTGTCCTTATCATGACTGCT
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCAGATGATTATCTGACCAAGCCTTTCTACCTTGAAGA
ACTCAAAATGCGGATCCAAGCCCTTCTCAAACGTTCAGGTAAGTTTAACGAAAATACCTTGACCTATGGGGATATTGTCG
TCAACCTTTCAACGAATGAAGTAAAAGTGGAAGATACTCCTGTGGAACTGCTTGGAAAAGAGTTTGAGTTATTGGTTTAC
TTCCTTCAAAATCAAAATGTCATTCTTCCCAAGACACAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACTAT
TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGGACAGCCTTTGCTGAGAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A4V0BT06

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae TIGR4	97.768	100	0.978
ciaR	Streptococcus pneumoniae D39	97.768	100	0.978
ciaR	Streptococcus pneumoniae R6	97.768	100	0.978
ciaR	Streptococcus pneumoniae Rx1	97.768	100	0.978
ciaR	Streptococcus mutans UA159	87.5	100	0.875
vicR	Streptococcus mutans UA159	36.481	100	0.379
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366