Detailed information NTG1161719

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: U8955_RS04140
• Genome accession: NZ_OY769914
• Coordinates: 816545..817882 (+)
• Length: 445 a.a.
• NCBI ID: WP_000482352.1
• Uniprot ID: A0A7T3DYE6
• Organism: Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 811545..822882

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U8955_RS04115 (SDENT7746_04135)	-	811648..812007 (+)	360	WP_000800853.1	hypothetical protein	-
U8955_RS04120 (SDENT7746_04140)	-	812041..812637 (+)	597	WP_001101063.1	DUF6707 family protein	-
U8955_RS04125 (SDENT7746_04145)	-	812662..813102 (+)	441	WP_000188803.1	ASCH domain-containing protein	-
U8955_RS04130 (SDENT7746_04150)	-	813225..815771 (+)	2547	WP_001149137.1	M1 family metallopeptidase	-
U8955_RS04135 (SDENT7746_04155)	ciaR	815881..816555 (+)	675	WP_000590630.1	two-component system response regulator CiaR	Regulator
U8955_RS04140 (SDENT7746_04160)	ciaH	816545..817882 (+)	1338	WP_000482352.1	sensor histidine kinase	Regulator
U8955_RS04145 (SDENT7746_04165)	-	817947..818231 (-)	285	WP_001111509.1	DUF3270 domain-containing protein	-
U8955_RS04150 (SDENT7746_04170)	-	818617..819672 (+)	1056	WP_000280274.1	ABC transporter permease	-
U8955_RS04155 (SDENT7746_04175)	-	819686..820366 (+)	681	WP_000125736.1	ABC transporter ATP-binding protein	-
U8955_RS04160 (SDENT7746_04180)	-	820492..821421 (+)	930	WP_038805085.1	peptidase U32 family protein	-
U8955_RS04165 (SDENT7746_04185)	rpiA	821526..822209 (+)	684	WP_038805086.1	ribose-5-phosphate isomerase RpiA	-

Sequence

Protein

• Length: 445 a.a.
• Molecular weight: 50799.53 Da
• Isoelectric Point: 9.5602

>NTDB_id=1161719 U8955_RS04140 WP_000482352.1 816545..817882(+) (ciaH) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSTSPQAVIQLALNRATEEVKDIQPAT
ADASKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSSTVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGLKPEIAEVSPQFFKTTFTNYELIASENDRVFDYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVYATDRHLYLTVADNGIGISAADKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKVAIQSPPKRKNK

Nucleotide

• Length: 1338 bp

>NTDB_id=1161719 U8955_RS04140 WP_000482352.1 816545..817882(+) (ciaH) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGTTCAATAAACTAAAAAAAACATGGTATGCGGATGATTTCAGTTATTTCATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCTGCTATGACCTTGATTATCCTTCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTACAAGCCC
TTAGCACTAGCCCTCAAGCTGTCATCCAATTAGCCCTTAATCGGGCAACTGAAGAAGTCAAAGATATTCAACCAGCAACA
GCGGATGCCAGCAAGGCTGAAATCAAGCCCAATGTCAGCTCCAATACGGAAGTCTTGCTCTTTGACAAGGATTTTAACCA
ACTCTTACTGGGTAACCGCTTTTTAGGCTTGGACAAGATCAAACTGGACAAGAAAGAGTTGAATCATATTCGGCAAATCC
AAGTTGTCAATAGCTACGGTCAGGAAGAAACCTACCGAATGATCTTGATGGAAACAAATTCGTCCACTGTTTCAAGCAAT
GTTAAATATGCGGCGGTTCTAATCAATACCAGCCAGCTTGAGCAAATCAGCCAAAATCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCCAGTGTTTACTTGGCACGTGTCAGTGTCAAACCCTTGCTGGAAAGTA
TGCAAAAGCAGAAGTCCTTTGTTGAAAATGCAAGCCACGAACTGAGAACACCTTTGGCTGTTTTACAAAATCGTTTAGAG
ACTCTCTTTCGAAAACCAGAAGCGACGATCATGGAATCCAGCGAAAGTATTGCTTCTAGCCTCGAAGAAGTTCGGAATAT
GCGTTTCCTTACAACCAACCTTCTCAATTTAGCACGTCGAGATGATGGACTTAAGCCAGAAATAGCAGAAGTTTCTCCAC
AATTCTTTAAAACCACCTTTACCAACTATGAGTTAATTGCTTCTGAAAATGATCGAGTTTTTGACTATGAAAATCGGATT
TATCGTCCCTTCATGACCGATCAGTTGCTCTTAAAACAACTCATGACCATCTTGTTTGATAATGCCATCAAGTATACCGA
AGAAGATGGAAAAATTGAGTTTGTGGTTTATGCTACAGATCGCCACCTCTATCTAACAGTAGCGGATAATGGGATTGGAA
TCTCAGCTGCTGACAAGAAGAAAATCTTTGACCGTTTTTACCGTGTAGACAAGGCGAGAACCCGTCAGAAAGGTGGCTTT
GGCCTTGGATTATCTTTGGCCAAGCAGATTGTTGATGCCTTACGAGGAACGATTAGCGTAAAAGATAACAAACCTAGAGG
AACGATTTTTGAAGTTAAAGTCGCTATCCAATCTCCTCCAAAACGAAAGAATAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (218-283)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

3D structure

• AlphaFold DB: A0A7T3DYE6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	83.973	99.551	0.836
ciaH	Streptococcus pneumoniae D39	83.973	99.551	0.836
ciaH	Streptococcus pneumoniae R6	83.973	99.551	0.836
ciaH	Streptococcus pneumoniae TIGR4	83.973	99.551	0.836
ciaH	Streptococcus mutans UA159	55.023	98.427	0.542