Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SMUFR_RS05225 Genome accession   NZ_CP007016
Coordinates   1070822..1071496 (-) Length   224 a.a.
NCBI ID   WP_002262214.1    Uniprot ID   Q8DU28
Organism   Streptococcus mutans UA159-FR     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1065822..1076496
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUFR_RS05200 (SMUFR_0982) - 1066129..1067406 (-) 1278 WP_002262219.1 pyrimidine-nucleoside phosphorylase -
  SMUFR_RS05205 (SMUFR_0983) - 1067515..1068111 (-) 597 WP_002262218.1 class I SAM-dependent methyltransferase -
  SMUFR_RS05210 (SMUFR_0984) coaA 1068207..1069127 (+) 921 WP_002262217.1 type I pantothenate kinase -
  SMUFR_RS05215 (SMUFR_0985) rpsT 1069181..1069435 (+) 255 WP_011074586.1 30S ribosomal protein S20 -
  SMUFR_RS05220 (SMUFR_0986) ciaH 1069525..1070832 (-) 1308 WP_039702578.1 three-component system sensor histidine kinase CiaH Regulator
  SMUFR_RS05225 (SMUFR_0987) ciaR 1070822..1071496 (-) 675 WP_002262214.1 three-component system response regulator CiaR Regulator
  SMUFR_RS05230 (SMUFR_0988) ciaX 1071547..1071810 (-) 264 WP_002262213.1 three-component system regulator CiaX -
  SMUFR_RS05235 (SMUFR_0989) - 1072211..1074760 (-) 2550 WP_002262212.1 M1 family metallopeptidase -
  SMUFR_RS05240 (SMUFR_0990) phoU 1074801..1075454 (-) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  SMUFR_RS05245 (SMUFR_0991) pstB 1075486..1076244 (-) 759 WP_002352282.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25475.23 Da        Isoelectric Point: 4.3425

>NTDB_id=115768 SMUFR_RS05225 WP_002262214.1 1070822..1071496(-) (ciaR) [Streptococcus mutans UA159-FR]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=115768 SMUFR_RS05225 WP_002262214.1 1070822..1071496(-) (ciaR) [Streptococcus mutans UA159-FR]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DU28

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

100

100

1
  ciaR Streptococcus pneumoniae Rx1

88.393

100

0.884
  ciaR Streptococcus pneumoniae D39

88.393

100

0.884
  ciaR Streptococcus pneumoniae R6

88.393

100

0.884
  ciaR Streptococcus pneumoniae TIGR4

88.393

100

0.884
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment