Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SMUFR_RS05220 Genome accession   NZ_CP007016
Coordinates   1069525..1070832 (-) Length   435 a.a.
NCBI ID   WP_039702578.1    Uniprot ID   -
Organism   Streptococcus mutans UA159-FR     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1064525..1075832
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUFR_RS05190 (SMUFR_0980) - 1065072..1065542 (-) 471 WP_230311800.1 cytidine deaminase -
  SMUFR_RS05195 (SMUFR_0981) deoC 1065448..1066110 (-) 663 WP_002262220.1 deoxyribose-phosphate aldolase -
  SMUFR_RS05200 (SMUFR_0982) - 1066129..1067406 (-) 1278 WP_002262219.1 pyrimidine-nucleoside phosphorylase -
  SMUFR_RS05205 (SMUFR_0983) - 1067515..1068111 (-) 597 WP_002262218.1 class I SAM-dependent methyltransferase -
  SMUFR_RS05210 (SMUFR_0984) coaA 1068207..1069127 (+) 921 WP_002262217.1 type I pantothenate kinase -
  SMUFR_RS05215 (SMUFR_0985) rpsT 1069181..1069435 (+) 255 WP_011074586.1 30S ribosomal protein S20 -
  SMUFR_RS05220 (SMUFR_0986) ciaH 1069525..1070832 (-) 1308 WP_039702578.1 three-component system sensor histidine kinase CiaH Regulator
  SMUFR_RS05225 (SMUFR_0987) ciaR 1070822..1071496 (-) 675 WP_002262214.1 three-component system response regulator CiaR Regulator
  SMUFR_RS05230 (SMUFR_0988) ciaX 1071547..1071810 (-) 264 WP_002262213.1 three-component system regulator CiaX -
  SMUFR_RS05235 (SMUFR_0989) - 1072211..1074760 (-) 2550 WP_002262212.1 M1 family metallopeptidase -
  SMUFR_RS05240 (SMUFR_0990) phoU 1074801..1075454 (-) 654 WP_002262211.1 phosphate signaling complex protein PhoU -

Sequence

Protein


Download         Length: 435 a.a.        Molecular weight: 49880.40 Da        Isoelectric Point: 9.7262

>NTDB_id=115767 SMUFR_RS05220 WP_039702578.1 1069525..1070832(-) (ciaH) [Streptococcus mutans UA159-FR]
MLIKLRKQKQDENISFFSHFFAVFTGIFFVMTVIIIQVMHFGIYSSVDNSLKIATENVNDYVNMTLSHNNPITEAENGDA
SFKVKSNGQMAANTDTILYDKKHNVINNVNAFSSLYHIRPKLKDIGDIVEQEAKNIYGQTEKYRTVTVKVNNDFYPQIKF
ATIVINTTQLEEANTRYVTIIISVMIVFWLISVIASVYLAKWSQKPILENYEKQKSFVENASHELRTPLAVLQNRLESLF
RKPEATILDSSESIASSLEEVRNMRMLTANLLNLARRDDGIKPEITEIQPRFFDDTFKNYEMIARENGKKLHIINKVNRQ
IKTDKTLLKQLMTILFDNAVKYTDNDGEIWLDVKTTDRSLIFSVADNGQGISDEDKKKIFDRFYRVDKARIRQKGGFGLG
LSLAKQITDSLKGSIIVKDKKPQGVMFEARLLANK

Nucleotide


Download         Length: 1308 bp        

>NTDB_id=115767 SMUFR_RS05220 WP_039702578.1 1069525..1070832(-) (ciaH) [Streptococcus mutans UA159-FR]
ATGCTAATTAAATTAAGAAAACAAAAGCAGGATGAGAATATTTCATTTTTCAGTCATTTCTTTGCTGTTTTTACCGGAAT
ATTCTTTGTTATGACAGTTATTATTATTCAGGTTATGCATTTTGGTATCTATTCTTCAGTTGATAATAGTCTAAAAATAG
CAACTGAGAATGTCAATGATTATGTCAATATGACTCTATCGCATAATAATCCTATTACTGAAGCTGAAAATGGAGATGCC
TCTTTTAAAGTAAAATCAAATGGCCAGATGGCTGCTAATACAGATACTATTCTTTATGATAAAAAGCATAACGTCATCAA
TAATGTCAATGCCTTCTCTTCTTTGTATCATATTCGCCCTAAACTAAAAGATATTGGTGATATTGTTGAACAAGAAGCTA
AGAATATTTACGGTCAGACCGAAAAGTATCGGACAGTGACAGTTAAGGTAAATAATGATTTTTACCCACAGATAAAATTT
GCAACAATTGTTATTAATACAACACAGCTTGAAGAGGCTAATACGCGTTATGTTACGATTATTATCAGTGTGATGATTGT
TTTTTGGCTTATATCAGTTATTGCCAGTGTTTATTTAGCGAAGTGGAGTCAAAAACCGATTCTGGAAAATTATGAAAAGC
AAAAATCATTTGTTGAAAATGCCAGTCATGAATTACGTACTCCTTTGGCTGTTTTGCAAAATCGCTTGGAGAGTTTGTTT
CGAAAACCAGAGGCTACTATCTTAGATTCTTCGGAATCTATTGCTTCTAGTTTGGAAGAGGTCAGAAACATGAGAATGCT
GACAGCAAATCTCCTTAATTTAGCCCGTCGGGATGATGGTATCAAACCAGAAATAACAGAAATTCAACCTCGTTTTTTTG
ATGATACTTTTAAAAATTATGAGATGATCGCTCGAGAAAATGGGAAAAAATTGCATATTATCAATAAGGTCAACCGTCAA
ATTAAGACAGATAAGACTTTGCTGAAGCAATTAATGACTATTCTTTTTGATAATGCTGTCAAATATACAGATAACGACGG
GGAAATTTGGCTGGACGTCAAGACAACTGATCGCAGTTTAATTTTTTCAGTTGCGGACAATGGTCAAGGTATTTCAGACG
AGGATAAGAAGAAAATTTTTGATCGTTTTTATCGCGTCGATAAAGCCAGAATACGACAAAAGGGTGGGTTCGGACTTGGT
TTGTCTTTGGCAAAACAAATAACAGACAGCTTAAAAGGCAGCATTATTGTTAAAGATAAAAAACCACAAGGAGTAATGTT
TGAAGCTCGCCTGCTTGCTAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-431)

His Kinase A (phospho-acceptor) domain (HisKA)

(215-280)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

99.77

100

0.998
  ciaH Streptococcus pneumoniae Rx1

55.402

100

0.554
  ciaH Streptococcus pneumoniae D39

55.402

100

0.554
  ciaH Streptococcus pneumoniae R6

55.402

100

0.554
  ciaH Streptococcus pneumoniae TIGR4

55.402

100

0.554

Multiple sequence alignment