Detailed information    

experimental Experimentally validated

Overview

Name   luxS   Type   Regulator
Locus tag   A1552VC_RS01665 Genome accession   NZ_CP028894
Coordinates   319588..320106 (+) Length   172 a.a.
NCBI ID   WP_001130227.1    Uniprot ID   -
Organism   Vibrio cholerae strain A1552     
Function   induction of competence   
Competence regulation

Function

The luxS gene encodes the autoinducer 2 (AI-2), which is involved in the induction of competence in Vibrio cholerae.


Genomic Context

Location: 314588..325106
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A1552VC_RS01655 (A1552VC_00324) - 314998..317853 (+) 2856 WP_001233047.1 pitrilysin family protein -
  A1552VC_RS01660 (A1552VC_00325) gshA 317965..319539 (+) 1575 WP_000032608.1 glutamate--cysteine ligase -
  A1552VC_RS01665 (A1552VC_00326) luxS 319588..320106 (+) 519 WP_001130227.1 S-ribosylhomocysteine lyase Regulator
  A1552VC_RS01670 (A1552VC_00327) - 320176..321456 (-) 1281 WP_000340990.1 HlyC/CorC family transporter -
  A1552VC_RS01675 (A1552VC_00328) - 321539..322333 (-) 795 WP_000369278.1 inner membrane protein YpjD -
  A1552VC_RS01680 (A1552VC_00329) ffh 322546..323931 (+) 1386 WP_000462720.1 signal recognition particle protein -
  A1552VC_RS01685 (A1552VC_00330) rpsP 324167..324415 (+) 249 WP_000256449.1 30S ribosomal protein S16 -
  A1552VC_RS01690 (A1552VC_00331) rimM 324443..324997 (+) 555 WP_000061906.1 ribosome maturation factor RimM -

Regulatory network

Positive effect      
Negative effect
Regulator Target Regulation
  luxS luxQ positive effect
  luxQ luxO positive effect
  luxO hapR positive effect
  cqsS luxO positive effect
  luxP luxO positive effect
  cqsA cqsS positive effect
  luxS luxP positive effect

Sequence

Protein


Download         Length: 172 a.a.        Molecular weight: 19080.90 Da        Isoelectric Point: 5.2199

>NTDB_id=1156 A1552VC_RS01665 WP_001130227.1 319588..320106(+) (luxS) [Vibrio cholerae strain A1552]
MPLLDSFTVDHTRMNAPAVRVAKTMQTPKGDTITVFDLRFTMPNKDILSERGIHTLEHLYAGFMRNHLNGSQVEIIDISP
MGCRTGFYMSLIGAPTEQQVAQAWLAAMQDVLKVESQEQIPELNEYQCGTAAMHSLEEAKAIAKNVIAAGISVNRNDELA
LPESMLNELKVH

Nucleotide


Download         Length: 519 bp        

>NTDB_id=1156 A1552VC_RS01665 WP_001130227.1 319588..320106(+) (luxS) [Vibrio cholerae strain A1552]
ATGCCATTATTAGACAGTTTTACCGTCGATCATACTCGTATGAATGCACCGGCGGTGCGTGTTGCCAAAACCATGCAAAC
CCCAAAAGGGGATACGATTACCGTATTTGATTTGCGTTTTACTATGCCAAACAAAGATATCTTGTCTGAGCGCGGTATCC
ATACTCTAGAGCATCTCTACGCGGGCTTTATGCGCAATCACCTTAACGGCAGCCAAGTGGAGATCATCGATATTTCACCA
ATGGGTTGCCGTACAGGTTTCTACATGAGCTTGATTGGTGCGCCGACAGAACAGCAAGTGGCACAAGCATGGCTAGCCGC
AATGCAAGATGTGTTGAAAGTTGAAAGCCAAGAGCAAATTCCTGAGCTGAATGAGTACCAGTGCGGCACTGCGGCGATGC
ACTCGCTCGAAGAAGCCAAAGCGATTGCGAAAAACGTGATTGCGGCAGGCATCTCGGTTAACCGTAACGATGAGTTGGCG
CTGCCCGAATCTATGCTCAATGAGCTGAAGGTTCACTAA

Domains

Predicted by InterproScan.

S-Ribosylhomocysteinase (LuxS) (LuxS)

(4-153)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value

References

[1] Sandrine Stutzmann et al. (2020) Comparison of chitin-induced natural transformation in pandemic Vibrio cholerae O1 El Tor strains. Environmental Microbiology 22(10):4149-4166. [PMID: 32860313]
[2] Calum Johnston et al. (2014) Bacterial transformation: distribution, shared mechanisms and divergent control. Nature Reviews. Microbiology 12(3):181-96. [PMID: 24509783]
[3] Gaia Suckow et al. (2011) Quorum sensing contributes to natural transformation of Vibrio cholerae in a species-specific manner. Journal of Bacteriology 193(18):4914-24. [PMID: 21784943]