Detailed information NTG1155613

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: QNH80_RS01990
• Genome accession: NZ_OX352996
• Coordinates: 406140..406811 (+)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis isolate 861160_dhsdS
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 401140..411811

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QNH80_RS01955	pstC	401323..402240 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
QNH80_RS01960	pstA	402230..403117 (+)	888	WP_002937616.1	phosphate ABC transporter permease PstA	-
QNH80_RS01965	pstB	403142..403945 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
QNH80_RS01970	pstB	403957..404715 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
QNH80_RS01975	phoU	404744..405400 (+)	657	WP_012028219.1	phosphate signaling complex protein PhoU	-
QNH80_RS01980	-	405566..405700 (+)	135	WP_255304292.1	hypothetical protein	-
QNH80_RS01985	-	405758..405946 (+)	189	WP_226313374.1	hypothetical protein	-
QNH80_RS01990	ciaR	406140..406811 (+)	672	WP_009909965.1	response regulator transcription factor	Regulator
QNH80_RS01995	ciaH	406804..408183 (+)	1380	WP_002935290.1	HAMP domain-containing sensor histidine kinase	Regulator
QNH80_RS02000	-	408507..409736 (+)	1230	WP_024417479.1	transglutaminase domain-containing protein	-
QNH80_RS02005	rpsT	409998..410246 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
QNH80_RS02010	coaA	410305..411225 (-)	921	WP_074390257.1	type I pantothenate kinase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=1155613 QNH80_RS01990 WP_009909965.1 406140..406811(+) (ciaR) [Streptococcus suis isolate 861160_dhsdS]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=1155613 QNH80_RS01990 WP_009909965.1 406140..406811(+) (ciaR) [Streptococcus suis isolate 861160_dhsdS]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGCCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363