Detailed information NTG1154324

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: AD178_RS06030
• Genome accession: NZ_OX244288
• Coordinates: 1189580..1190284 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain PT8105 isolate 2RLC4
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1184580..1195284

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AD178_RS06000 (SAMEA1463109_01212)	-	1184769..1185755 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
AD178_RS06005 (SAMEA1463109_01213)	-	1186018..1186791 (-)	774	WP_000731128.1	ion channel	-
AD178_RS06010 (SAMEA1463109_01214)	-	1186838..1187092 (-)	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AD178_RS06015 (SAMEA1463109_01215)	relB	1187094..1187336 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
AD178_RS06020 (SAMEA1463109_01216)	vicX	1187427..1188236 (-)	810	WP_044814286.1	MBL fold metallo-hydrolase	Regulator
AD178_RS06025 (SAMEA1463109_01217)	micB	1188238..1189587 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
AD178_RS06030 (SAMEA1463109_01218)	micA	1189580..1190284 (-)	705	WP_000722076.1	response regulator YycF	Regulator
AD178_RS06035 (SAMEA1463109_01219)	mutY	1190339..1191514 (-)	1176	WP_000886145.1	A/G-specific adenine glycosylase	-
AD178_RS06040	-	1191611..1191736 (+)	126	WP_001818232.1	hypothetical protein	-
AD178_RS06045 (SAMEA1463109_01220)	-	1191842..1193512 (-)	1671	WP_000845290.1	formate--tetrahydrofolate ligase	-
AD178_RS06050 (SAMEA1463109_01221)	coaB	1193742..1194431 (+)	690	WP_000699488.1	phosphopantothenate--cysteine ligase	-
AD178_RS06055 (SAMEA1463109_01222)	coaC	1194443..1194994 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1154324 AD178_RS06030 WP_000722076.1 1189580..1190284(-) (micA) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1154324 AD178_RS06030 WP_000722076.1 1189580..1190284(-) (micA) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACAAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38