Detailed information NTG1154301

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: AD178_RS00515
• Genome accession: NZ_OX244288
• Coordinates: 81315..83468 (+)
• Length: 717 a.a.
• NCBI ID: WP_000668294.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PT8105 isolate 2RLC4
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 76315..88468

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AD178_RS00480 (SAMEA1463109_00100)	-	76666..77835 (+)	1170	WP_000366342.1	pyridoxal phosphate-dependent aminotransferase	-
AD178_RS00485 (SAMEA1463109_00101)	recO	77832..78602 (+)	771	WP_000616122.1	DNA repair protein RecO	-
AD178_RS00490 (SAMEA1463109_00102)	plsX	78599..79591 (+)	993	WP_000717458.1	phosphate acyltransferase PlsX	-
AD178_RS00495 (SAMEA1463109_00103)	-	79597..79830 (+)	234	WP_000136449.1	acyl carrier protein	-
AD178_RS00500	-	79876..80167 (+)	292	Protein_92	IS5/IS1182 family transposase	-
AD178_RS00505 (SAMEA1463109_00104)	blpU	80370..80600 (+)	231	WP_001093075.1	bacteriocin-like peptide BlpU	-
AD178_RS00510 (SAMEA1463109_00105)	-	80603..80728 (+)	126	WP_000346297.1	PncF family bacteriocin immunity protein	-
AD178_RS00515 (SAMEA1463109_00106)	comA	81315..83468 (+)	2154	WP_000668294.1	peptide cleavage/export ABC transporter ComA	Regulator
AD178_RS00520 (SAMEA1463109_00107)	comB	83481..84830 (+)	1350	WP_000801591.1	competence pheromone export protein ComB	Regulator
AD178_RS00525 (SAMEA1463109_00108)	purC	85000..85707 (+)	708	WP_000043304.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
AD178_RS11095	-	85718..85852 (+)	135	WP_000429436.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80408.47 Da
• Isoelectric Point: 6.2590

>NTDB_id=1154301 AD178_RS00515 WP_000668294.1 81315..83468(+) (comA) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVYYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=1154301 AD178_RS00515 WP_000668294.1 81315..83468(+) (comA) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTCATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCCTACGCTCAGGAGTATCTCTTACTTGTTTTGGGGCAACGTTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTGCCTATGTCCTTTTTTGCGACACGCAGAACAGGGGAAATTGTGTC
TCGTTTCACGGATGCTAATAGTATCATCGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACCTTATTGGCACTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCTTTTGAAAAGATGAATCGGGACACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATTAAGTCCTTGACCAGTGAAAGTCAACGTTATCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAAAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAAGTTGCCCATCTC
TTGCTCAATGTCGGCATTCTCTGGATGGGAGCTGTTCTGGTCATGGATGGTAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTACTTGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTATATCTGGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATCTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTTACTACAAGTATGGCTATGGTCGAGATGTCTTGTCAGACATCAATTTGACCAT
TCCCCAAGGTTCTAAAGTGGCTTTTGTGGGAATTTCAGGGTCAGGTAAGACGACCTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTATATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTCCTTGGGGCCAAGGAAGGGACGAC
TCAAGAGGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGGGAGGACATTGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATTGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACCAGCAGTCTGGATATCTTGACTGAGAAGCGAATTGTCGATAATCTCATGGCTTT
AGACAAGACCTTGATTTTCATTGCTCACCGCTTGACCATTGCAGAGCGGACAGAGAAGGTTGTTGTCTTGGATCAGGGCA
AGATTGTTGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter transmembrane region (ABC_membrane) (170-438)

• ABC transporter (ABC_tran) (500-650)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus pneumoniae Rx1	99.582	100	0.996
comA	Streptococcus pneumoniae D39	99.582	100	0.996
comA	Streptococcus pneumoniae R6	99.582	100	0.996
comA	Streptococcus pneumoniae TIGR4	99.163	100	0.992
comA	Streptococcus mitis SK321	98.884	100	0.989
comA	Streptococcus mitis NCTC 12261	98.745	100	0.987
comA	Streptococcus gordonii str. Challis substr. CH1	80.893	100	0.809
comA/nlmT	Streptococcus mutans UA159	64.993	100	0.65