Detailed information NTG1143668

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: BJR96_RS00435
• Genome accession: NZ_LT545678
• Coordinates: 68711..69613 (+)
• Length: 300 a.a.
• NCBI ID: WP_000912098.1
• Uniprot ID: A0AAD2WWZ7
• Organism: Streptococcus agalactiae isolate SA111
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 63711..74613

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BJR96_RS00410 (SA111_00074)	-	64260..65432 (+)	1173	WP_001248533.1	hypothetical protein	-
BJR96_RS00415 (SA111_00075)	-	65712..66083 (+)	372	WP_001872566.1	hypothetical protein	-
BJR96_RS00420 (SA111_00076)	-	66050..66454 (+)	405	WP_228305700.1	DUF6261 family protein	-
BJR96_RS00425 (SA111_00077)	-	66454..67263 (+)	810	WP_000982340.1	hypothetical protein	-
BJR96_RS00430 (SA111_00078)	purB	67260..68558 (+)	1299	WP_000572889.1	adenylosuccinate lyase	-
BJR96_RS00435 (SA111_00079)	comR	68711..69613 (+)	903	WP_000912098.1	helix-turn-helix domain-containing protein	Regulator
BJR96_RS00440 (SA111_00080)	ruvB	69902..70900 (+)	999	WP_069986619.1	Holliday junction branch migration DNA helicase RuvB	-
BJR96_RS00445 (SA111_00081)	-	71052..71489 (+)	438	WP_000754818.1	low molecular weight protein-tyrosine-phosphatase	-
BJR96_RS00450 (SA111_00082)	-	71496..71876 (+)	381	WP_000787702.1	membrane protein	-
BJR96_RS00455 (SA111_00083)	-	71873..73651 (+)	1779	WP_001220906.1	acyltransferase family protein	-

Sequence

Protein

• Length: 300 a.a.
• Molecular weight: 35606.08 Da
• Isoelectric Point: 6.5030

>NTDB_id=1143668 BJR96_RS00435 WP_000912098.1 68711..69613(+) (comR) [Streptococcus agalactiae isolate SA111]
MLKHFGSKVRNLRVTRNITREDFCGDETELSVRQLARIESGQSIPNLTKAHYIAKQLNVKLDILTGGESLELPKRYKELK
YKLLRTPTYGDANRLAVREAYFDEIYEVFYEELPEDERLIIDCMQSKLDVHFSVNDNFGITILHDYFDQIKKKKEYTTND
FVMIDLYLLCFSINYGMKSLYSLENYHFIMSKLLEQDNLLPEDNFQLNNVLLNHVELAFQFKQKKYVQQIIHRSNAIMTE
IHDFQKRPILSLIEWKYLLIIEKDRTKAETCFKQSILFAELIGDLYLKGKLIEEWNKDLT

Nucleotide

• Length: 903 bp

>NTDB_id=1143668 BJR96_RS00435 WP_000912098.1 68711..69613(+) (comR) [Streptococcus agalactiae isolate SA111]
ATGTTAAAACATTTTGGTAGTAAAGTAAGAAATTTGAGAGTAACTAGAAATATTACTCGCGAAGATTTTTGTGGTGATGA
AACTGAGTTATCTGTAAGACAATTAGCTAGGATTGAAAGTGGACAGTCAATTCCAAACTTGACTAAAGCTCACTACATAG
CTAAACAATTGAATGTAAAATTGGATATTTTAACAGGAGGAGAGAGCTTAGAATTACCTAAACGGTATAAAGAGTTGAAG
TACAAATTGTTGCGTACCCCGACTTACGGAGATGCTAATAGACTTGCAGTTAGAGAAGCATATTTTGATGAAATCTATGA
AGTATTTTATGAGGAGCTCCCAGAAGATGAAAGACTAATTATTGATTGTATGCAATCAAAATTAGATGTTCATTTTTCTG
TTAATGATAATTTTGGAATCACTATTTTACATGACTACTTTGATCAAATTAAGAAAAAAAAGGAATATACCACAAATGAT
TTTGTTATGATAGATTTATATTTACTTTGCTTTTCTATTAACTATGGAATGAAGAGCTTGTATTCTTTAGAGAACTATCA
TTTTATTATGTCAAAATTGTTAGAGCAAGATAATTTACTTCCTGAGGATAATTTTCAATTGAACAACGTTTTATTAAATC
ATGTCGAATTAGCTTTTCAATTTAAGCAGAAAAAATATGTACAGCAAATTATTCATAGAAGTAATGCTATTATGACAGAA
ATCCATGATTTTCAAAAAAGACCAATACTAAGCTTAATAGAGTGGAAATATTTATTAATTATTGAAAAAGATAGAACAAA
AGCAGAAACATGTTTTAAACAATCAATTCTATTTGCAGAGTTAATAGGTGATCTATATTTAAAAGGAAAATTAATAGAGG
AGTGGAATAAAGATTTAACATGA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-295)

• Helix-turn-helix (HTH_3) (10-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	59.375	96	0.57
comR	Streptococcus mutans UA159	52.174	99.667	0.52
comR	Streptococcus pyogenes MGAS8232	50.166	100	0.503
comR	Streptococcus pyogenes MGAS315	47.667	100	0.477
comR	Streptococcus suis P1/7	40.067	99	0.397
comR	Streptococcus suis 05ZYH33	40.067	99	0.397
comR	Streptococcus suis D9	36.184	100	0.367