Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQL00_RS09975 Genome accession   NZ_LS483523
Coordinates   1874132..1874806 (-) Length   224 a.a.
NCBI ID   WP_023396212.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 4041STDY6836169     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1869132..1879806
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL00_RS09960 - 1871418..1872347 (-) 930 WP_000411863.1 peptidase U32 family protein -
  DQL00_RS09965 - 1872487..1872774 (+) 288 WP_001145225.1 DUF3270 domain-containing protein -
  DQL00_RS09970 ciaH 1872808..1874142 (-) 1335 WP_000491784.1 two-component system sensor histidine kinase CiaH Regulator
  DQL00_RS09975 ciaR 1874132..1874806 (-) 675 WP_023396212.1 two-component system response regulator CiaR Regulator
  DQL00_RS09980 - 1874915..1877461 (-) 2547 WP_001149118.1 M1 family metallopeptidase -
  DQL00_RS09985 - 1877584..1878024 (-) 441 WP_000188826.1 ASCH domain-containing protein -
  DQL00_RS09990 - 1877999..1878868 (-) 870 WP_023396211.1 putative PEP-binding protein -
  DQL00_RS09995 - 1878846..1879346 (-) 501 WP_000403338.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25482.33 Da        Isoelectric Point: 4.3283

>NTDB_id=1142987 DQL00_RS09975 WP_023396212.1 1874132..1874806(-) (ciaR) [Streptococcus pneumoniae strain 4041STDY6836169]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLLEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1142987 DQL00_RS09975 WP_023396212.1 1874132..1874806(-) (ciaR) [Streptococcus pneumoniae strain 4041STDY6836169]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCTAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus mutans UA159

87.946

100

0.879
  vicR Streptococcus mutans UA159

35.193

100

0.366
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment