Detailed information NTG1142986

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: DQL00_RS09970
• Genome accession: NZ_LS483523
• Coordinates: 1872808..1874142 (-)
• Length: 444 a.a.
• NCBI ID: WP_000491784.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 4041STDY6836169
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1867808..1879142

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL00_RS09950	-	1868768..1871218 (-)	2451	WP_000848703.1	bifunctional DnaQ family exonuclease/ATP-dependent helicase	-
DQL00_RS09960	-	1871418..1872347 (-)	930	WP_000411863.1	peptidase U32 family protein	-
DQL00_RS09965	-	1872487..1872774 (+)	288	WP_001145225.1	DUF3270 domain-containing protein	-
DQL00_RS09970	ciaH	1872808..1874142 (-)	1335	WP_000491784.1	two-component system sensor histidine kinase CiaH	Regulator
DQL00_RS09975	ciaR	1874132..1874806 (-)	675	WP_023396212.1	two-component system response regulator CiaR	Regulator
DQL00_RS09980	-	1874915..1877461 (-)	2547	WP_001149118.1	M1 family metallopeptidase	-
DQL00_RS09985	-	1877584..1878024 (-)	441	WP_000188826.1	ASCH domain-containing protein	-
DQL00_RS09990	-	1877999..1878868 (-)	870	WP_023396211.1	putative PEP-binding protein	-

Sequence

Protein

• Length: 444 a.a.
• Molecular weight: 50674.37 Da
• Isoelectric Point: 8.8698

>NTDB_id=1142986 DQL00_RS09970 WP_000491784.1 1872808..1874142(-) (ciaH) [Streptococcus pneumoniae strain 4041STDY6836169]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLEDAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide

• Length: 1335 bp

>NTDB_id=1142986 DQL00_RS09970 WP_000491784.1 1872808..1874142(-) (ciaH) [Streptococcus pneumoniae strain 4041STDY6836169]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGTAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAGATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATAAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTACGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAAGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (217-283)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	99.775	100	0.998
ciaH	Streptococcus pneumoniae D39	99.775	100	0.998
ciaH	Streptococcus pneumoniae R6	99.775	100	0.998
ciaH	Streptococcus pneumoniae TIGR4	99.775	100	0.998
ciaH	Streptococcus mutans UA159	55.402	97.973	0.543