Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   DQN30_RS03550 Genome accession   NZ_LS483458
Coordinates   696045..697382 (+) Length   445 a.a.
NCBI ID   WP_111696323.1    Uniprot ID   A0A2X4RCM2
Organism   Haemophilus haemolyticus strain NCTC10839     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 691045..702382
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN30_RS03525 (NCTC10839_00695) - 691098..693701 (-) 2604 WP_111696318.1 penicillin-binding protein 1A -
  DQN30_RS03530 (NCTC10839_00696) comA 693800..694597 (+) 798 WP_111696319.1 pilus assembly protein PilM Machinery gene
  DQN30_RS03535 (NCTC10839_00697) comB 694598..695107 (+) 510 WP_111696320.1 competence protein B Machinery gene
  DQN30_RS03540 (NCTC10839_00698) comC 695104..695625 (+) 522 WP_111696321.1 competence protein ComC Machinery gene
  DQN30_RS03545 (NCTC10839_00699) comD 695622..696035 (+) 414 WP_111696322.1 pilus assembly protein PilP Machinery gene
  DQN30_RS03550 (NCTC10839_00700) comE 696045..697382 (+) 1338 WP_111696323.1 type IV pilus secretin PilQ family protein Machinery gene
  DQN30_RS03555 (NCTC10839_00701) - 697395..698081 (+) 687 WP_111696324.1 ComF family protein -
  DQN30_RS03560 (NCTC10839_00702) nfuA 698157..698753 (+) 597 WP_046939969.1 Fe-S biogenesis protein NfuA -
  DQN30_RS03565 (NCTC10839_00703) nudC 698821..699615 (+) 795 WP_111696325.1 NAD(+) diphosphatase -
  DQN30_RS03570 (NCTC10839_00704) - 699651..700241 (+) 591 WP_111696326.1 YjaG family protein -
  DQN30_RS03575 (NCTC10839_00705) - 700379..700651 (+) 273 WP_005634530.1 HU family DNA-binding protein -
  DQN30_RS03580 (NCTC10839_00706) - 700779..701552 (+) 774 WP_111696327.1 DeoR/GlpR family DNA-binding transcription regulator -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 48911.07 Da        Isoelectric Point: 6.7039

>NTDB_id=1142190 DQN30_RS03550 WP_111696323.1 696045..697382(+) (comE) [Haemophilus haemolyticus strain NCTC10839]
MKKYLLKCGCFLMCFWLPLIVFANPKTDNERFFIRLSQAPLAQTLDQLAFQHDVNLVMDETLEGNISLKLDNIDMPRLLQ
IIAKSKKLTLNKDEGIYYLNGGQSGKAQVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPAGSITFDDRSN
LLVIQDEPSSVQNIKKLISEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENGARVAGSLAGNGFENITDNLNVN
FATTTTPAGSVALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYVVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PGIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=1142190 DQN30_RS03550 WP_111696323.1 696045..697382(+) (comE) [Haemophilus haemolyticus strain NCTC10839]
ATGAAGAAATATCTTTTAAAGTGCGGTTGTTTTTTAATGTGTTTTTGGTTGCCATTAATCGTTTTTGCTAACCCCAAAAC
TGATAACGAACGTTTTTTTATTCGTTTGTCGCAAGCGCCTTTAGCTCAAACACTGGATCAATTAGCTTTTCAACATGATG
TCAATTTAGTGATGGATGAGACGTTAGAAGGCAATATTTCTTTGAAATTAGATAATATTGATATGCCACGTTTGCTACAA
ATAATCGCTAAAAGTAAGAAGCTTACTTTGAATAAAGATGAGGGCATTTATTATCTGAATGGAGGGCAATCAGGCAAAGC
TCAAGTTGCAGGAAATCTTACTACAAATGAACCGCACTTAGTGAGTCACACGGTTAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAATCCTTAACAACAGGAAGTGGATCGTTGCTTTCACCAGCTGGAAGCATCACCTTTGATGATCGCAGTAAT
TTGCTGGTTATTCAGGATGAGCCTAGTTCTGTGCAAAATATCAAAAAACTAATTTCTGAAATGGATAAACCTATTGAGCA
GATCGCTATTGAAGCACGTATTGTGACAATTACAGATGAGAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACGGAAAATGGTGCGCGTGTAGCGGGCAGCTTAGCCGGAAATGGCTTTGAAAATATTACGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCCGCTGGCTCTGTAGCATTACAGGTCGCGAAAATTAATGGGCGATTGCTTGATTTAGAATT
GAGCGCTTTAGAGCGTGAAAATAATGTAGAAATTATCGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGGACAGAAATTCCTTACGTCGTGAGCAATACTCGTAATGATACACAATCTGTCGAATTTCGTGAGGCAGTG
CTTGGTTTGGAAGTGACGCCACATATTTCTAAAGATAACAATATTTTGCTTGATTTATTAGTGAGCCAAAACTCACCAGG
TTCTCGTGTCGCTTATGGACAAAACGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCTAAAGATG
GGGAAACCATTGTGCTTGGCGGTGTGTTCCACGATACGATCACGAAAAGCGAAGATAAAGTGCCATTACTTGGCGATATA
CCTGGCATTAAACGATTGTTTAGTAAAGAAAGTGAACGACATCAAAAACGTGAGTTAGTGATTTTCGTGACGCCGCATAT
TTTAAAAGCAGGAGAAACGTTAGAGGCGTTGAAACAAAAAAGTGCGGGTAAAAAATAA

Domains

Predicted by InterproScan.

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)

Bacterial type II and III secretion system protein (Secretin)

(269-429)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X4RCM2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae Rd KW20

93.708

100

0.937
  comE Haemophilus influenzae 86-028NP

93.708

100

0.937
  comE Glaesserella parasuis strain SC1401

52.817

95.73

0.506
  pilQ Vibrio campbellii strain DS40M4

42.482

94.157

0.4
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

41.505

92.584

0.384
  pilQ Vibrio cholerae strain A1552

41.505

92.584

0.384

Multiple sequence alignment