Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   DQL12_RS06465 Genome accession   NZ_LS483450
Coordinates   1214480..1215184 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 4041STDY6583227     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1209480..1220184
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL12_RS06440 - 1209792..1211663 (-) 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
  DQL12_RS06445 - 1211738..1211992 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE family toxin -
  DQL12_RS06450 relB 1211994..1212236 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  DQL12_RS06455 vicX 1212327..1213136 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  DQL12_RS06460 micB 1213138..1214487 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  DQL12_RS06465 micA 1214480..1215184 (-) 705 WP_000722076.1 response regulator YycF Regulator
  DQL12_RS06470 mutY 1215239..1216414 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  DQL12_RS12480 - 1216511..1216636 (+) 126 WP_001818232.1 hypothetical protein -
  DQL12_RS06475 - 1216742..1218412 (-) 1671 WP_000845290.1 formate--tetrahydrofolate ligase -
  DQL12_RS06480 coaB 1218642..1219331 (+) 690 WP_050255441.1 phosphopantothenate--cysteine ligase -
  DQL12_RS06485 coaC 1219343..1219894 (+) 552 WP_044727478.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=1141980 DQL12_RS06465 WP_000722076.1 1214480..1215184(-) (micA) [Streptococcus pneumoniae strain 4041STDY6583227]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=1141980 DQL12_RS06465 WP_000722076.1 1214480..1215184(-) (micA) [Streptococcus pneumoniae strain 4041STDY6583227]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCACGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment