Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   DQL12_RS02650 Genome accession   NZ_LS483450
Coordinates   491993..492730 (+) Length   245 a.a.
NCBI ID   WP_001219120.1    Uniprot ID   Q9S1I6
Organism   Streptococcus pneumoniae strain 4041STDY6583227     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 486993..497730
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL12_RS02615 - 488325..488612 (-) 288 WP_000777760.1 hypothetical protein -
  DQL12_RS02620 - 488622..489032 (-) 411 WP_001278301.1 HIT family protein -
  DQL12_RS02625 pptA 489100..489831 (+) 732 WP_000889924.1 ABC transporter ATP-binding protein Regulator
  DQL12_RS02630 - 489828..490877 (+) 1050 WP_000653779.1 ABC transporter permease -
  DQL12_RS02640 - 491045..491374 (-) 330 WP_000132572.1 hypothetical protein -
  DQL12_RS02645 - 491650..491988 (+) 339 WP_000876675.1 LytTR family DNA-binding domain-containing protein -
  DQL12_RS02650 comE/blpR 491993..492730 (+) 738 WP_001219120.1 response regulator transcription factor Regulator
  DQL12_RS02655 - 492744..494084 (+) 1341 WP_001017646.1 sensor histidine kinase -
  DQL12_RS02660 blpC 494155..494283 (-) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  DQL12_RS02665 - 494340..495701 (-) 1362 WP_001069075.1 bacteriocin secretion accessory protein -
  DQL12_RS02670 comA/nlmT 495712..497388 (-) 1677 WP_162480916.1 peptide cleavage/export ABC transporter Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28754.98 Da        Isoelectric Point: 6.5884

>NTDB_id=1141965 DQL12_RS02650 WP_001219120.1 491993..492730(+) (comE/blpR) [Streptococcus pneumoniae strain 4041STDY6583227]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1141965 DQL12_RS02650 WP_001219120.1 491993..492730(+) (comE/blpR) [Streptococcus pneumoniae strain 4041STDY6583227]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1I6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.017

98.776

0.376
  comE Streptococcus infantis strain Atu-4

35.887

100

0.363

Multiple sequence alignment