Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   DQK98_RS02630 Genome accession   NZ_LS483449
Coordinates   499774..500511 (+) Length   245 a.a.
NCBI ID   WP_001219146.1    Uniprot ID   A0A1C0UQ30
Organism   Streptococcus pneumoniae strain 4041STDY6836170     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 494774..505511
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQK98_RS11285 - 495704..495943 (-) 240 WP_001813906.1 hypothetical protein -
  DQK98_RS02600 - 496105..496392 (-) 288 WP_000777760.1 hypothetical protein -
  DQK98_RS02605 - 496402..496812 (-) 411 WP_001278301.1 HIT family protein -
  DQK98_RS02610 pptA 496880..497611 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  DQK98_RS02615 - 497608..498657 (+) 1050 WP_000653771.1 ABC transporter permease -
  DQK98_RS02620 - 498825..499154 (-) 330 WP_000132572.1 hypothetical protein -
  DQK98_RS02625 - 499431..499769 (+) 339 WP_000682132.1 LytTR family DNA-binding domain-containing protein -
  DQK98_RS02630 comE/blpR 499774..500511 (+) 738 WP_001219146.1 response regulator transcription factor Regulator
  DQK98_RS02635 - 500525..501865 (+) 1341 WP_001099895.1 sensor histidine kinase -
  DQK98_RS02640 blpC 501909..502064 (-) 156 WP_044791640.1 quorum-sensing system pheromone BlpC -
  DQK98_RS02645 - 502121..503482 (-) 1362 Protein_504 bacteriocin secretion accessory protein -
  DQK98_RS02650 comA/nlmT 503493..505169 (-) 1677 WP_196299874.1 peptide cleavage/export ABC transporter Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28768.87 Da        Isoelectric Point: 6.0454

>NTDB_id=1141888 DQK98_RS02630 WP_001219146.1 499774..500511(+) (comE/blpR) [Streptococcus pneumoniae strain 4041STDY6836170]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1141888 DQK98_RS02630 WP_001219146.1 499774..500511(+) (comE/blpR) [Streptococcus pneumoniae strain 4041STDY6836170]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1C0UQ30

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384
  comE Streptococcus infantis strain Atu-4

36.179

100

0.363

Multiple sequence alignment