Detailed information NTG1141240

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQN28_RS00325
• Genome accession: NZ_LS483430
• Coordinates: 53159..54070 (+)
• Length: 303 a.a.
• NCBI ID: WP_111686142.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12044
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48159..59070

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN28_RS00305 (NCTC12044_00062)	purE	48455..48946 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQN28_RS00310 (NCTC12044_00063)	purK	48933..50006 (+)	1074	WP_172453905.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQN28_RS00315 (NCTC12044_00064)	-	50027..51367 (+)	1341	WP_002986685.1	hypothetical protein	-
DQN28_RS00320 (NCTC12044_00065)	purB	51736..53028 (+)	1293	WP_111686141.1	adenylosuccinate lyase	-
DQN28_RS00325 (NCTC12044_00066)	comR	53159..54070 (+)	912	WP_111686142.1	helix-turn-helix domain-containing protein	Regulator
DQN28_RS09035 (NCTC12044_00067)	comS	54161..54259 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
DQN28_RS00330 (NCTC12044_00068)	ruvB	54290..55288 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQN28_RS00335 (NCTC12044_00069)	-	55426..55863 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQN28_RS00340 (NCTC12044_00070)	-	55886..56287 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
DQN28_RS00345 (NCTC12044_00071)	-	56284..58059 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35850.52 Da
• Isoelectric Point: 5.0238

>NTDB_id=1141240 DQN28_RS00325 WP_111686142.1 53159..54070(+) (comR) [Streptococcus pyogenes strain NCTC12044]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREGQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNIFLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDISRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=1141240 DQN28_RS00325 WP_111686142.1 53159..54070(+) (comR) [Streptococcus pyogenes strain NCTC12044]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGGGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTTTTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAG
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	98.68	100	0.987
comR	Streptococcus pyogenes MGAS8232	58.14	99.34	0.578
comR	Streptococcus mutans UA159	46.823	98.68	0.462
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.102	97.36	0.449
comR	Streptococcus suis P1/7	37.037	98.02	0.363
comR	Streptococcus suis 05ZYH33	37.037	98.02	0.363