Detailed information NTG1140874

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: DQN54_RS06080
• Genome accession: NZ_LS483417
• Coordinates: 1147677..1148381 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain NCTC11902
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1142677..1153381

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN54_RS06050 (NCTC11902_01155)	-	1142990..1143976 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
DQN54_RS06055 (NCTC11902_01156)	-	1144236..1144888 (-)	653	Protein_1149	potassium channel family protein	-
DQN54_RS06060 (NCTC11902_01157)	-	1144935..1145189 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE family toxin	-
DQN54_RS06065 (NCTC11902_01158)	relB	1145191..1145433 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
DQN54_RS06070 (NCTC11902_01159)	vicX	1145524..1146333 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
DQN54_RS06075 (NCTC11902_01160)	micB	1146335..1147684 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DQN54_RS06080 (NCTC11902_01161)	micA	1147677..1148381 (-)	705	WP_000722076.1	response regulator YycF	Regulator
DQN54_RS06085 (NCTC11902_01162)	mutY	1148436..1149611 (-)	1176	WP_000886145.1	A/G-specific adenine glycosylase	-
DQN54_RS06090 (NCTC11902_01163)	-	1149939..1151609 (-)	1671	WP_000845294.1	formate--tetrahydrofolate ligase	-
DQN54_RS06095 (NCTC11902_01164)	coaB	1151839..1152528 (+)	690	WP_000699495.1	phosphopantothenate--cysteine ligase	-
DQN54_RS06100 (NCTC11902_01165)	coaC	1152540..1153091 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1140874 DQN54_RS06080 WP_000722076.1 1147677..1148381(-) (micA) [Streptococcus pneumoniae strain NCTC11902]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1140874 DQN54_RS06080 WP_000722076.1 1147677..1148381(-) (micA) [Streptococcus pneumoniae strain NCTC11902]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38