Detailed information NTG1138896

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: DQM56_RS04860
• Genome accession: NZ_LS483368
• Coordinates: 1013131..1013805 (+)
• Length: 224 a.a.
• NCBI ID: WP_012515548.1
• Uniprot ID: B4U2R0
• Organism: Streptococcus equi subsp. zooepidemicus strain NCTC6176
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1008131..1018805

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM56_RS04845 (NCTC6176_00980)	pstB	1008459..1009217 (+)	759	WP_012678019.1	phosphate ABC transporter ATP-binding protein PstB	-
DQM56_RS04850 (NCTC6176_00981)	phoU	1009288..1009941 (+)	654	WP_012678018.1	phosphate signaling complex protein PhoU	-
DQM56_RS04855 (NCTC6176_00982)	-	1010176..1012713 (+)	2538	WP_014622811.1	M1 family metallopeptidase	-
DQM56_RS04860 (NCTC6176_00983)	ciaR	1013131..1013805 (+)	675	WP_012515548.1	response regulator transcription factor	Regulator
DQM56_RS04865 (NCTC6176_00984)	ciaH	1013798..1015108 (+)	1311	WP_111710546.1	sensor histidine kinase	Regulator
DQM56_RS04870 (NCTC6176_00985)	-	1015493..1015927 (+)	435	WP_043026495.1	hypothetical protein	-
DQM56_RS10025 (NCTC6176_00986)	-	1016009..1016185 (+)	177	WP_014622814.1	hypothetical protein	-
DQM56_RS04875 (NCTC6176_00987)	-	1016201..1016608 (+)	408	WP_111710547.1	hypothetical protein	-
DQM56_RS04880 (NCTC6176_00988)	-	1016618..1017811 (+)	1194	WP_111710548.1	hypothetical protein	-
DQM56_RS04885 (NCTC6176_00989)	-	1017808..1018200 (+)	393	WP_111710549.1	hypothetical protein	-
DQM56_RS04890 (NCTC6176_00990)	-	1018219..1018503 (+)	285	WP_111710550.1	hypothetical protein	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25541.52 Da
• Isoelectric Point: 4.5644

>NTDB_id=1138896 DQM56_RS04860 WP_012515548.1 1013131..1013805(+) (ciaR) [Streptococcus equi subsp. zooepidemicus strain NCTC6176]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE

Nucleotide

• Length: 675 bp

>NTDB_id=1138896 DQM56_RS04860 WP_012515548.1 1013131..1013805(+) (ciaR) [Streptococcus equi subsp. zooepidemicus strain NCTC6176]
ATGATAAAACTATTATTAGTAGAAGACGATTTAAGCTTGTCAAATTCTATCTTTGATTTTTTAGATGACTTTGCTGATGT
GACGCAGGTTTTTGATGGTGACGAAGGACTCTATGAGGCAGAAAGCGGTATTTATGATTTGATTCTGTTAGATTTGATGC
TGCCTGAAAAGGATGGCTTTCAAGTGTTAAAAGCCTTACGTGAAAAAGACATCAAAATTCCCGTCTTGATCATGACTGCC
AAAGAAAGCATCGATGACAAGGGGCATGGCTTTGAGCTTGGTGCTGATGACTATTTAACTAAGCCCTTTTACCTAGAAGA
ATTAAAAATGCGGATTCAGGCCTTGCTTAAGCGTGTAGGAAAGTTTAATGATAAGAGCCTTAAATTTGGCAACTTGACTG
TAGATACTACCCGTAAAGAGGTACAGGTCAATGGGCAGGCCATAGAGCTATTAGGCAAGGAGCTTGATTTACTAATCTAT
ATCCTTCAAAATCAAAATGTTATTTTGCCAAAATCACAAATTTTTGATCGTATCTGGGGCTTTGATAGTGATACCACTAT
CTCTGTTGTAGAGGTCTATGTCTCTAAAATTCGTAAGAAGCTTAAGGGGACAGACTTTGTTAATCATCTTCAAACCTTGA
GAAGTGTAGGATATATCTTAAAAGCTAATGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: B4U2R0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae Rx1	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae D39	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae R6	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae TIGR4	80.543	98.661	0.795
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.428	100	0.393
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362