Detailed information NTG1138776

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: DQM60_RS04235
• Genome accession: NZ_LS483366
• Coordinates: 957909..958583 (+)
• Length: 224 a.a.
• NCBI ID: WP_049546057.1
• Uniprot ID: A0A1V0H9R4
• Organism: Streptococcus salivarius strain NCTC7366
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 952909..963583

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM60_RS04210 (NCTC7366_00851)	-	953397..953957 (-)	561	WP_004182060.1	ECF transporter S component	-
DQM60_RS04215 (NCTC7366_00852)	-	954024..954596 (-)	573	WP_084871334.1	ECF transporter S component	-
DQM60_RS04220 (NCTC7366_00853)	coaC	954625..955170 (-)	546	WP_084871335.1	phosphopantothenoylcysteine decarboxylase	-
DQM60_RS04225 (NCTC7366_00854)	-	955163..955846 (-)	684	WP_084871336.1	phosphopantothenate--cysteine ligase	-
DQM60_RS04230 (NCTC7366_00855)	-	956040..957710 (+)	1671	WP_084871337.1	formate--tetrahydrofolate ligase	-
DQM60_RS04235 (NCTC7366_00856)	ciaR	957909..958583 (+)	675	WP_049546057.1	response regulator transcription factor	Regulator
DQM60_RS04240 (NCTC7366_00857)	ciaH	958573..959988 (+)	1416	WP_004182392.1	sensor histidine kinase	Regulator
DQM60_RS04245 (NCTC7366_00858)	rpsT	960066..960302 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
DQM60_RS04250 (NCTC7366_00859)	coaA	960372..961292 (-)	921	WP_004182393.1	type I pantothenate kinase	-
DQM60_RS04255 (NCTC7366_00860)	-	961405..961995 (+)	591	WP_004182394.1	class I SAM-dependent methyltransferase	-
DQM60_RS04260 (NCTC7366_00861)	-	961992..963269 (+)	1278	WP_004182395.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25347.99 Da
• Isoelectric Point: 4.2845

>NTDB_id=1138776 DQM60_RS04235 WP_049546057.1 957909..958583(+) (ciaR) [Streptococcus salivarius strain NCTC7366]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELRDKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=1138776 DQM60_RS04235 WP_049546057.1 957909..958583(+) (ciaR) [Streptococcus salivarius strain NCTC7366]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAGGTATTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTTTATGATTTGATTCTTTTAGACTTAATGT
TGCCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGACAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGCCACGGCTTTGAACTTGGTGCAGATGACTACCTAACTAAGCCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTCTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTAAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A1V0H9R4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae D39	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae R6	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae TIGR4	86.996	99.554	0.866
ciaR	Streptococcus mutans UA159	86.161	100	0.862
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362