Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQM55_RS06985 Genome accession   NZ_LS483364
Coordinates   1376010..1376684 (-) Length   224 a.a.
NCBI ID   WP_002897753.1    Uniprot ID   A0A2X4AMM1
Organism   Streptococcus sanguinis strain NCTC11086     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1371010..1381684
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM55_RS06965 (NCTC11086_01440) - 1371717..1373114 (-) 1398 WP_111675946.1 polysaccharide deacetylase family protein -
  DQM55_RS06970 (NCTC11086_01441) - 1373176..1373562 (-) 387 WP_002895748.1 VOC family protein -
  DQM55_RS06975 (NCTC11086_01442) - 1373675..1374613 (-) 939 WP_061592832.1 ketopantoate reductase family protein -
  DQM55_RS06980 (NCTC11086_01443) ciaH 1374629..1376020 (-) 1392 WP_002904314.1 sensor histidine kinase Regulator
  DQM55_RS06985 (NCTC11086_01444) ciaR 1376010..1376684 (-) 675 WP_002897753.1 response regulator transcription factor Regulator
  DQM55_RS06990 (NCTC11086_01445) - 1376789..1377271 (-) 483 WP_111675947.1 hypothetical protein -
  DQM55_RS06995 (NCTC11086_01446) - 1377452..1378267 (-) 816 WP_002909957.1 SDR family NAD(P)-dependent oxidoreductase -
  DQM55_RS07000 (NCTC11086_01447) - 1378271..1378597 (-) 327 WP_002900559.1 DMT family transporter -
  DQM55_RS07005 (NCTC11086_01448) - 1378653..1378937 (-) 285 WP_002909958.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25209.95 Da        Isoelectric Point: 4.4858

>NTDB_id=1138673 DQM55_RS06985 WP_002897753.1 1376010..1376684(-) (ciaR) [Streptococcus sanguinis strain NCTC11086]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLRAKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLSYGDVTVNLSTNSTTKAGKDVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTAFAKNLHTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1138673 DQM55_RS06985 WP_002897753.1 1376010..1376684(-) (ciaR) [Streptococcus sanguinis strain NCTC11086]
ATGATTAAAATTCTATTGGTAGAAGATGACCTTGGACTGTCAAACTCAGTTTTTGATTTTTTAGATGATTTTGCAGATGT
AATGCAGGTTTTTGATGGTGAAGAAGGTCTATATGAAGCAGAAAGCGGTGTTTATGACCTCATCTTGCTGGATCTCATGC
TGCCTGAAAAGGACGGTTTCCAAGTGCTGAAAGATCTCCGAGCAAAAGGAGTTACAACACCTGTTCTCATCATGACAGCT
AAGGAAAGCTTGGATGACAAAGGACATGGCTTTGAGCTCGGAGCTGACGACTATCTGACAAAACCTTTCTATTTGGAAGA
ACTGAAAATGCGGATCCAGGCGCTCTTGAAACGCGCTGGTAAATTCAACGAGAATACTCTTTCTTATGGTGATGTAACTG
TCAACCTATCTACAAATTCAACCACGAAGGCTGGTAAAGACGTAGAGTTGCTTGGTAAAGAGTTCGACCTCTTGGTTTAT
TTCCTGCAAAATCAAAATGTAATCTTGCCTAAGACTCAAATTTTTGACCGTCTGTGGGGCTTTGACAGTGATACCACTGT
TTCCGTTGTCGAAGTGTACGTTTCAAAGATTCGTAAAAAACTGAAAGGAACGGCATTTGCGAAAAACCTACATACTCTTC
GTAGTGTCGGCTACATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X4AMM1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

88.839

100

0.888
  ciaR Streptococcus pneumoniae D39

88.839

100

0.888
  ciaR Streptococcus pneumoniae R6

88.839

100

0.888
  ciaR Streptococcus pneumoniae TIGR4

88.839

100

0.888
  ciaR Streptococcus mutans UA159

87.444

99.554

0.871
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment