Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   DQM55_RS06980 Genome accession   NZ_LS483364
Coordinates   1374629..1376020 (-) Length   463 a.a.
NCBI ID   WP_002904314.1    Uniprot ID   A0A2X4AJ38
Organism   Streptococcus sanguinis strain NCTC11086     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1369629..1381020
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM55_RS06960 (NCTC11086_01439) - 1370532..1371623 (+) 1092 WP_111675945.1 DEAD/DEAH box helicase -
  DQM55_RS06965 (NCTC11086_01440) - 1371717..1373114 (-) 1398 WP_111675946.1 polysaccharide deacetylase family protein -
  DQM55_RS06970 (NCTC11086_01441) - 1373176..1373562 (-) 387 WP_002895748.1 VOC family protein -
  DQM55_RS06975 (NCTC11086_01442) - 1373675..1374613 (-) 939 WP_061592832.1 ketopantoate reductase family protein -
  DQM55_RS06980 (NCTC11086_01443) ciaH 1374629..1376020 (-) 1392 WP_002904314.1 sensor histidine kinase Regulator
  DQM55_RS06985 (NCTC11086_01444) ciaR 1376010..1376684 (-) 675 WP_002897753.1 response regulator transcription factor Regulator
  DQM55_RS06990 (NCTC11086_01445) - 1376789..1377271 (-) 483 WP_111675947.1 hypothetical protein -
  DQM55_RS06995 (NCTC11086_01446) - 1377452..1378267 (-) 816 WP_002909957.1 SDR family NAD(P)-dependent oxidoreductase -
  DQM55_RS07000 (NCTC11086_01447) - 1378271..1378597 (-) 327 WP_002900559.1 DMT family transporter -
  DQM55_RS07005 (NCTC11086_01448) - 1378653..1378937 (-) 285 WP_002909958.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 463 a.a.        Molecular weight: 52603.01 Da        Isoelectric Point: 8.4934

>NTDB_id=1138672 DQM55_RS06980 WP_002904314.1 1374629..1376020(-) (ciaH) [Streptococcus sanguinis strain NCTC11086]
MLNKIKKTFYADDFSYFIRYFGLFTLIFSAMTLIIIQVMRSSLYTSVDENLKNLSNDPSSVADLAYRTTGQQSDPSNKVN
SKSPKSSKEPDGDSDEEPKPNNLTTPNVSSNTFALLLDDDYKNISTSKSDGFLDFNSLEFNKSYLNQIKEIVIGNSFGQT
ESYRAYLFDIDPKNEYPDIKYAVVMTSISQLEQTSSKHEQLIAMVMVSFWGISLIASIYLARMSVKPLLESIQKQKAFVE
NASHELRTPLAVLQSRLETLFRKPEATIMQSSENIASSLDEVRNMRLLTTNLLNLARRDDGIKPQYGEVEPEFFDTTFAN
YCIIARENKKAFHSENMIKHPIVTDQIFLKQLMTILFDNAIKYTDDDGVISVMATSTDRYLIFRVADNGPGISDEDKKKI
FDRFYRVDKARTRQKGGFGLGLSLAKQIVDAFKGSIYVKDNKPKGTVFEVKLLLKETKKRSVK

Nucleotide


Download         Length: 1392 bp        

>NTDB_id=1138672 DQM55_RS06980 WP_002904314.1 1374629..1376020(-) (ciaH) [Streptococcus sanguinis strain NCTC11086]
ATGCTGAATAAAATCAAGAAGACCTTTTATGCGGATGATTTCTCTTATTTCATTCGCTATTTTGGGTTGTTTACATTAAT
CTTCTCAGCCATGACCTTGATTATTATTCAGGTTATGCGCTCCAGCCTTTATACGTCAGTTGATGAAAATCTGAAAAACC
TGAGTAATGATCCTAGTTCAGTAGCTGATTTGGCCTATCGGACGACAGGCCAGCAGTCTGATCCAAGCAATAAGGTCAAT
TCTAAAAGTCCTAAAAGCAGTAAAGAGCCAGATGGTGATTCAGATGAAGAGCCTAAGCCTAACAATCTAACTACGCCAAA
TGTCAGCTCTAATACTTTTGCCCTGCTTTTGGATGATGATTATAAAAATATTTCCACCAGCAAGAGCGATGGTTTTCTGG
ACTTTAATTCATTAGAGTTTAACAAGTCCTATCTAAATCAAATCAAGGAAATTGTGATTGGTAACAGCTTTGGCCAAACG
GAGAGCTATCGGGCTTATCTCTTTGATATTGATCCTAAAAATGAGTATCCTGATATCAAGTACGCTGTGGTCATGACTAG
TATCAGCCAGCTGGAGCAGACCAGCAGCAAGCATGAGCAGTTGATTGCCATGGTCATGGTCAGCTTTTGGGGAATTTCCC
TGATTGCCAGTATTTACCTTGCTCGGATGAGTGTCAAGCCTCTGCTGGAAAGTATCCAGAAGCAGAAGGCTTTTGTGGAA
AATGCCAGTCACGAACTACGGACTCCTCTGGCAGTATTGCAGAGCCGCTTAGAGACGCTCTTTCGTAAGCCTGAAGCTAC
AATAATGCAGAGCAGTGAAAATATTGCTTCTAGCTTGGATGAAGTACGGAATATGCGCTTGCTGACGACCAATCTGCTCA
ACCTGGCCCGCCGCGATGATGGCATCAAGCCACAATATGGTGAAGTTGAACCAGAATTTTTTGATACGACCTTTGCTAAT
TACTGTATTATCGCAAGGGAGAATAAAAAAGCCTTTCATTCAGAAAATATGATCAAGCACCCTATTGTGACCGATCAAAT
TTTTCTCAAACAACTGATGACCATTCTATTTGACAATGCTATCAAGTACACAGATGATGATGGCGTAATCAGTGTCATGG
CTACTTCGACAGATCGCTACCTTATTTTCCGAGTGGCGGACAATGGTCCTGGTATCAGCGATGAAGATAAAAAGAAGATT
TTTGATCGCTTTTATCGGGTGGACAAGGCTCGGACCCGTCAGAAAGGTGGCTTTGGTCTGGGGCTTTCTCTGGCTAAGCA
GATTGTCGATGCTTTCAAAGGCTCTATTTATGTCAAGGACAACAAACCAAAAGGTACGGTCTTTGAAGTTAAACTGCTCC
TGAAAGAAACGAAAAAGCGTTCTGTTAAATAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(236-301)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(344-454)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X4AJ38

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

60.738

99.568

0.605
  ciaH Streptococcus pneumoniae D39

60.738

99.568

0.605
  ciaH Streptococcus pneumoniae R6

60.738

99.568

0.605
  ciaH Streptococcus pneumoniae TIGR4

60.738

99.568

0.605
  ciaH Streptococcus mutans UA159

53.289

98.488

0.525

Multiple sequence alignment