Detailed information NTG1138334

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: DQM46_RS04635
• Genome accession: NZ_LS483357
• Coordinates: 899034..899870 (-)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain NCTC8326
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 894034..904870

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM46_RS04610 (NCTC8326_00920)	-	894252..895244 (-)	993	WP_021299266.1	D-lactate dehydrogenase	-
DQM46_RS04615 (NCTC8326_00921)	-	895259..895825 (-)	567	Protein_826	PTS sugar transporter subunit IIC	-
DQM46_RS09795	-	895838..896722 (+)	885	Protein_827	LysR family transcriptional regulator	-
DQM46_RS04630 (NCTC8326_00923)	topA	896798..898927 (-)	2130	WP_011528644.1	type I DNA topoisomerase	-
DQM46_RS04635 (NCTC8326_00924)	dprA	899034..899870 (-)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
DQM46_RS04640 (NCTC8326_00925)	-	899935..900726 (-)	792	WP_011017771.1	ribonuclease HII	-
DQM46_RS04645 (NCTC8326_00926)	ylqF	900716..901564 (-)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
DQM46_RS04650 (NCTC8326_00927)	-	901783..902223 (+)	441	WP_011017769.1	DUF1836 domain-containing protein	-
DQM46_RS04655 (NCTC8326_00928)	trhA	902220..902870 (+)	651	WP_002984629.1	PAQR family membrane homeostasis protein TrhA	-
DQM46_RS04660 (NCTC8326_00929)	-	902987..903898 (+)	912	WP_011528643.1	diacylglycerol/lipid kinase family protein	-
DQM46_RS04665 (NCTC8326_00930)	-	903948..904382 (-)	435	WP_021299262.1	hypothetical protein	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=1138334 DQM46_RS04635 WP_011017772.1 899034..899870(-) (dprA) [Streptococcus pyogenes strain NCTC8326]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=1138334 DQM46_RS04635 WP_011017772.1 899034..899870(-) (dprA) [Streptococcus pyogenes strain NCTC8326]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367