Detailed information NTG1138128

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DQL39_RS08985
• Genome accession: NZ_LS483353
• Coordinates: 1764030..1765253 (+)
• Length: 407 a.a.
• NCBI ID: WP_002981947.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC4001
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1759030..1770253

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL39_RS08965 (NCTC4001_01773)	clpC	1759463..1761907 (+)	2445	WP_002991294.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
DQL39_RS08970 (NCTC4001_01774)	-	1761904..1762923 (-)	1020	WP_038433776.1	IS30-like element IS1239 family transposase	-
DQL39_RS08980 (NCTC4001_01776)	rlmH	1763339..1763818 (-)	480	WP_011889262.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQL39_RS08985 (NCTC4001_01777)	htrA	1764030..1765253 (+)	1224	WP_002981947.1	S1C family serine protease	Regulator
DQL39_RS08990 (NCTC4001_01778)	spo0J	1765342..1766118 (+)	777	WP_002981939.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42758.40 Da
• Isoelectric Point: 7.3920

>NTDB_id=1138128 DQL39_RS08985 WP_002981947.1 1764030..1765253(+) (htrA) [Streptococcus pyogenes strain NCTC4001]
MPSMKHILKSLSVLLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKIVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide

• Length: 1224 bp

>NTDB_id=1138128 DQL39_RS08985 WP_002981947.1 1764030..1765253(+) (htrA) [Streptococcus pyogenes strain NCTC4001]
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTGTTTTACTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTTAATAATCTCTACCCACATTCTCCTTCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGGATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGATTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAACCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGATGTTATTAAAATTATTAAACAACTAGAAA
CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGACTTATCCACAAATGCTCTTAGCCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAATAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (301-396)

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.634	99.263	0.612
htrA	Streptococcus gordonii str. Challis substr. CH1	55.473	98.771	0.548
htrA	Streptococcus mitis NCTC 12261	53.317	100	0.533
htrA	Streptococcus pneumoniae Rx1	53.071	100	0.531
htrA	Streptococcus pneumoniae D39	53.071	100	0.531
htrA	Streptococcus pneumoniae R6	53.071	100	0.531
htrA	Streptococcus pneumoniae TIGR4	53.071	100	0.531