Detailed information NTG1138077

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQL39_RS00265
• Genome accession: NZ_LS483353
• Coordinates: 46947..47858 (+)
• Length: 303 a.a.
• NCBI ID: WP_011888526.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC4001
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 41947..52858

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL39_RS00245 (NCTC4001_00049)	purE	42536..43024 (+)	489	WP_038433064.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQL39_RS00250 (NCTC4001_00050)	purK	43011..44084 (+)	1074	WP_038433065.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQL39_RS00255 (NCTC4001_00051)	-	44086..45504 (+)	1419	WP_038433067.1	hypothetical protein	-
DQL39_RS00260 (NCTC4001_00052)	purB	45524..46816 (+)	1293	WP_011888525.1	adenylosuccinate lyase	-
DQL39_RS00265 (NCTC4001_00053)	comR	46947..47858 (+)	912	WP_011888526.1	helix-turn-helix domain-containing protein	Regulator
DQL39_RS09105 (NCTC4001_00054)	comS	47949..48047 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
DQL39_RS00270 (NCTC4001_00055)	ruvB	48078..49076 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQL39_RS00275 (NCTC4001_00056)	-	49214..49651 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQL39_RS00280 (NCTC4001_00057)	-	49674..50075 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
DQL39_RS00285 (NCTC4001_00058)	-	50072..51847 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35915.59 Da
• Isoelectric Point: 4.9349

>NTDB_id=1138077 DQL39_RS00265 WP_011888526.1 46947..47858(+) (comR) [Streptococcus pyogenes strain NCTC4001]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=1138077 DQL39_RS00265 WP_011888526.1 46947..47858(+) (comR) [Streptococcus pyogenes strain NCTC4001]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.67	100	0.997
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366