Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQM59_RS05150 Genome accession   NZ_LS483349
Coordinates   988947..989621 (+) Length   224 a.a.
NCBI ID   WP_002262214.1    Uniprot ID   Q8DU28
Organism   Streptococcus mutans strain NCTC10449     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 983947..994621
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM59_RS05130 (NCTC10449_00991) pstB 984226..984984 (+) 759 WP_002262210.1 phosphate ABC transporter ATP-binding protein PstB -
  DQM59_RS05135 (NCTC10449_00992) phoU 985016..985669 (+) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  DQM59_RS05140 (NCTC10449_00993) - 985710..988259 (+) 2550 WP_002280152.1 M1 family metallopeptidase -
  DQM59_RS05145 (NCTC10449_00995) - 988660..988896 (+) 237 WP_002280153.1 hypothetical protein -
  DQM59_RS05150 (NCTC10449_00996) ciaR 988947..989621 (+) 675 WP_002262214.1 three-component system response regulator CiaR Regulator
  DQM59_RS05155 (NCTC10449_00997) ciaH 989611..990918 (+) 1308 WP_002276249.1 three-component system sensor histidine kinase CiaH Regulator
  DQM59_RS05160 (NCTC10449_00998) rpsT 991007..991261 (-) 255 WP_011074586.1 30S ribosomal protein S20 -
  DQM59_RS05165 (NCTC10449_00999) coaA 991315..992235 (-) 921 WP_002262217.1 type I pantothenate kinase -
  DQM59_RS05170 (NCTC10449_01000) - 992331..992927 (+) 597 WP_002270201.1 class I SAM-dependent methyltransferase -
  DQM59_RS05175 (NCTC10449_01001) - 993036..994313 (+) 1278 WP_002280154.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25475.23 Da        Isoelectric Point: 4.3425

>NTDB_id=1137887 DQM59_RS05150 WP_002262214.1 988947..989621(+) (ciaR) [Streptococcus mutans strain NCTC10449]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1137887 DQM59_RS05150 WP_002262214.1 988947..989621(+) (ciaR) [Streptococcus mutans strain NCTC10449]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DU28

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

100

100

1
  ciaR Streptococcus pneumoniae Rx1

88.393

100

0.884
  ciaR Streptococcus pneumoniae D39

88.393

100

0.884
  ciaR Streptococcus pneumoniae R6

88.393

100

0.884
  ciaR Streptococcus pneumoniae TIGR4

88.393

100

0.884
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment