Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   DQM59_RS05155 Genome accession   NZ_LS483349
Coordinates   989611..990918 (+) Length   435 a.a.
NCBI ID   WP_002276249.1    Uniprot ID   -
Organism   Streptococcus mutans strain NCTC10449     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 984611..995918
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM59_RS05135 (NCTC10449_00992) phoU 985016..985669 (+) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  DQM59_RS05140 (NCTC10449_00993) - 985710..988259 (+) 2550 WP_002280152.1 M1 family metallopeptidase -
  DQM59_RS05145 (NCTC10449_00995) - 988660..988896 (+) 237 WP_002280153.1 hypothetical protein -
  DQM59_RS05150 (NCTC10449_00996) ciaR 988947..989621 (+) 675 WP_002262214.1 three-component system response regulator CiaR Regulator
  DQM59_RS05155 (NCTC10449_00997) ciaH 989611..990918 (+) 1308 WP_002276249.1 three-component system sensor histidine kinase CiaH Regulator
  DQM59_RS05160 (NCTC10449_00998) rpsT 991007..991261 (-) 255 WP_011074586.1 30S ribosomal protein S20 -
  DQM59_RS05165 (NCTC10449_00999) coaA 991315..992235 (-) 921 WP_002262217.1 type I pantothenate kinase -
  DQM59_RS05170 (NCTC10449_01000) - 992331..992927 (+) 597 WP_002270201.1 class I SAM-dependent methyltransferase -
  DQM59_RS05175 (NCTC10449_01001) - 993036..994313 (+) 1278 WP_002280154.1 pyrimidine-nucleoside phosphorylase -
  DQM59_RS05180 (NCTC10449_01002) deoC 994332..994994 (+) 663 WP_002280155.1 deoxyribose-phosphate aldolase -
  DQM59_RS05185 (NCTC10449_01003) - 994900..995370 (+) 471 WP_012997758.1 cytidine deaminase -

Sequence

Protein


Download         Length: 435 a.a.        Molecular weight: 49868.35 Da        Isoelectric Point: 9.7262

>NTDB_id=1137888 DQM59_RS05155 WP_002276249.1 989611..990918(+) (ciaH) [Streptococcus mutans strain NCTC10449]
MLIKLRKQKQDENISFFSHFFAVFTGIFFVMTVIIIQVMHFGIYSSVDNSLKIATENVNDYVNMTLSHNNPITEAENGDA
SFKVKSNGQMAANTDTILYDKKHNVINNVNAFSSLYHIRPKLKDIGDIVEQEAKNIYGQTEKYRTVTVKVNNDFYPQIKF
ATIVINTTQLEEANTRYVTIIISVMIVFWLISVIASVYLAKWSQKPILENYEKQKSFVENASHELRTPLAVLQNRLESLF
RKPEATILDSSESIASSLEEVRNMRMLTANLLNLARRDDGIKPEITEIQPRFFDDTFKNYEMIARENGKKLHITNKVNRQ
IKTDKTLLKQLMTILFDNAVKYTDNDGEIWLDVKITDRSLIFSVADNGQGISDEDKKKIFDRFYRVDKARTRQKGGFGLG
LSLAKQITDSLKGSIIVKDKKPQGVMFEARLLANK

Nucleotide


Download         Length: 1308 bp        

>NTDB_id=1137888 DQM59_RS05155 WP_002276249.1 989611..990918(+) (ciaH) [Streptococcus mutans strain NCTC10449]
ATGCTAATTAAATTAAGAAAACAAAAGCAGGATGAGAATATTTCATTTTTCAGTCATTTCTTTGCTGTTTTTACCGGAAT
ATTCTTTGTTATGACAGTTATTATTATTCAGGTTATGCATTTTGGTATCTATTCTTCAGTTGATAATAGTCTAAAAATAG
CAACTGAGAATGTCAATGATTATGTCAATATGACTCTATCGCATAATAATCCTATTACTGAAGCTGAAAATGGAGATGCC
TCTTTTAAAGTAAAATCAAATGGCCAGATGGCTGCTAATACAGATACTATTCTTTATGATAAAAAGCATAACGTCATCAA
TAATGTCAATGCCTTCTCTTCTTTGTATCATATTCGCCCTAAACTAAAAGATATTGGTGATATTGTTGAACAAGAAGCTA
AGAATATTTACGGTCAGACCGAAAAGTATCGGACAGTGACAGTTAAGGTAAATAATGATTTTTACCCACAGATAAAATTT
GCAACAATTGTTATTAATACAACACAGCTTGAAGAGGCTAATACGCGTTATGTTACGATTATTATCAGTGTGATGATTGT
TTTTTGGCTTATATCAGTTATTGCCAGTGTTTATTTAGCGAAGTGGAGTCAAAAACCGATTCTGGAAAATTATGAAAAGC
AAAAATCATTTGTTGAAAATGCCAGTCATGAATTACGTACTCCTTTGGCTGTTTTGCAAAATCGCTTGGAGAGTTTGTTT
CGAAAACCAGAGGCTACTATCTTAGATTCTTCGGAATCTATTGCTTCTAGTTTGGAAGAGGTCAGAAACATGAGAATGCT
GACAGCAAATCTCCTTAATTTAGCCCGTCGGGATGATGGTATCAAACCAGAAATAACAGAAATTCAACCTCGTTTTTTTG
ATGATACTTTTAAAAATTATGAGATGATCGCTCGAGAAAATGGGAAAAAATTGCATATTACCAATAAGGTCAACCGTCAA
ATTAAGACAGATAAGACTTTGCTGAAGCAATTAATGACTATTCTTTTTGATAATGCTGTCAAATATACAGATAACGACGG
GGAAATTTGGCTGGACGTCAAGATAACTGATCGCAGTTTAATTTTTTCAGTTGCGGACAATGGTCAAGGTATTTCAGACG
AGGATAAGAAAAAAATTTTTGATCGTTTTTATCGCGTCGATAAAGCCAGAACACGACAAAAGGGTGGGTTCGGACTTGGT
TTGTCTTTGGCAAAACAAATAACAGACAGCTTAAAAGGCAGCATTATTGTTAAAGATAAAAAACCACAAGGAGTAATGTT
TGAAGCTCGCCTGCTTGCTAATAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(215-280)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-431)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

99.54

100

0.995
  ciaH Streptococcus pneumoniae Rx1

55.632

100

0.556
  ciaH Streptococcus pneumoniae D39

55.632

100

0.556
  ciaH Streptococcus pneumoniae R6

55.632

100

0.556
  ciaH Streptococcus pneumoniae TIGR4

55.632

100

0.556

Multiple sequence alignment