Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQM73_RS04830 Genome accession   NZ_LS483346
Coordinates   977658..978332 (+) Length   224 a.a.
NCBI ID   WP_002925094.1    Uniprot ID   -
Organism   Streptococcus sanguinis strain NCTC11085     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 972658..983332
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM73_RS04810 (NCTC11085_00940) - 975399..975683 (+) 285 WP_002925100.1 helix-turn-helix domain-containing protein -
  DQM73_RS04815 (NCTC11085_00941) - 975739..976065 (+) 327 WP_002904310.1 multidrug efflux SMR transporter -
  DQM73_RS04820 (NCTC11085_00942) - 976069..976884 (+) 816 WP_002925099.1 SDR family oxidoreductase -
  DQM73_RS04825 (NCTC11085_00943) - 977071..977553 (+) 483 WP_002925096.1 hypothetical protein -
  DQM73_RS04830 (NCTC11085_00944) ciaR 977658..978332 (+) 675 WP_002925094.1 response regulator transcription factor Regulator
  DQM73_RS04835 (NCTC11085_00945) ciaH 978322..979713 (+) 1392 WP_002925091.1 cell wall metabolism sensor histidine kinase WalK Regulator
  DQM73_RS04840 (NCTC11085_00946) - 979729..980667 (+) 939 WP_002906765.1 ketopantoate reductase family protein -
  DQM73_RS04845 (NCTC11085_00947) - 980779..981165 (+) 387 WP_002895748.1 VOC family protein -
  DQM73_RS04850 (NCTC11085_00948) - 981227..982624 (+) 1398 WP_002925089.1 polysaccharide deacetylase family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25252.98 Da        Isoelectric Point: 4.5520

>NTDB_id=1137701 DQM73_RS04830 WP_002925094.1 977658..978332(+) (ciaR) [Streptococcus sanguinis strain NCTC11085]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLRAKGVTTPVLIMTA
KESLDDKGHGFERGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLSYGDVTVNLSTNSTTKAGKDVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTAFAKNLHTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1137701 DQM73_RS04830 WP_002925094.1 977658..978332(+) (ciaR) [Streptococcus sanguinis strain NCTC11085]
ATGATTAAAATTCTATTGGTAGAAGATGACCTTGGACTGTCAAACTCAGTTTTTGATTTTTTGGATGATTTTGCAGATGT
AATGCAGGTTTTTGATGGCGAAGAAGGTCTATATGAAGCAGAGAGCGGTGTTTATGACCTTATCTTGCTGGATCTCATGC
TTCCTGAAAAGGATGGTTTTCAAGTGCTGAAAGATCTTCGGGCAAAAGGAGTCACAACCCCTGTTCTCATCATGACAGCT
AAGGAAAGCTTGGATGACAAAGGACATGGCTTTGAGCGCGGCGCTGATGACTATCTGACCAAACCTTTCTATTTGGAAGA
ACTGAAAATGCGGATCCAAGCACTCTTGAAACGTGCTGGTAAATTCAACGAGAATACTCTTTCTTATGGTGATGTGACTG
TCAACCTATCTACAAATTCAACCACGAAGGCAGGTAAAGATGTAGAGTTGCTTGGTAAAGAGTTCGACCTCTTGGTTTAT
TTCCTGCAAAATCAAAATGTAATCTTGCCTAAGACTCAAATTTTTGACCGTCTGTGGGGCTTTGACAGTGATACCACTGT
TTCCGTTGTCGAAGTGTACGTTTCAAAGATTCGTAAAAAACTGAAAGGAACGGCATTTGCGAAAAACCTACATACTCTTC
GTAGTGTCGGCTACATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

88.393

100

0.884
  ciaR Streptococcus pneumoniae D39

88.393

100

0.884
  ciaR Streptococcus pneumoniae R6

88.393

100

0.884
  ciaR Streptococcus pneumoniae TIGR4

88.393

100

0.884
  ciaR Streptococcus mutans UA159

86.996

99.554

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment