Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   DQM73_RS04835 Genome accession   NZ_LS483346
Coordinates   978322..979713 (+) Length   463 a.a.
NCBI ID   WP_002925091.1    Uniprot ID   A0A2X3VAS7
Organism   Streptococcus sanguinis strain NCTC11085     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 973322..984713
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM73_RS04810 (NCTC11085_00940) - 975399..975683 (+) 285 WP_002925100.1 helix-turn-helix domain-containing protein -
  DQM73_RS04815 (NCTC11085_00941) - 975739..976065 (+) 327 WP_002904310.1 multidrug efflux SMR transporter -
  DQM73_RS04820 (NCTC11085_00942) - 976069..976884 (+) 816 WP_002925099.1 SDR family oxidoreductase -
  DQM73_RS04825 (NCTC11085_00943) - 977071..977553 (+) 483 WP_002925096.1 hypothetical protein -
  DQM73_RS04830 (NCTC11085_00944) ciaR 977658..978332 (+) 675 WP_002925094.1 response regulator transcription factor Regulator
  DQM73_RS04835 (NCTC11085_00945) ciaH 978322..979713 (+) 1392 WP_002925091.1 cell wall metabolism sensor histidine kinase WalK Regulator
  DQM73_RS04840 (NCTC11085_00946) - 979729..980667 (+) 939 WP_002906765.1 ketopantoate reductase family protein -
  DQM73_RS04845 (NCTC11085_00947) - 980779..981165 (+) 387 WP_002895748.1 VOC family protein -
  DQM73_RS04850 (NCTC11085_00948) - 981227..982624 (+) 1398 WP_002925089.1 polysaccharide deacetylase family protein -
  DQM73_RS04855 (NCTC11085_00949) - 982718..983809 (-) 1092 WP_002925087.1 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 463 a.a.        Molecular weight: 52685.11 Da        Isoelectric Point: 8.4934

>NTDB_id=1137702 DQM73_RS04835 WP_002925091.1 978322..979713(+) (ciaH) [Streptococcus sanguinis strain NCTC11085]
MLNKIKKTFYADDFSYFIRYFGLFTLIFSAMTLIIIQVMRSSLYTSVDENLKNLSNDPSSVADLAYRTTGQQSDPSNKVN
TKSPKNNKEPDGDSDEEPKPNNLTTPNVSSNTFALLLDDDYKNISTSKSDGFLDFNSLEFNKSYLNQIKEIVIGNSFGQT
ESYRAYLFDIDPKNEYPDIKYAVVMTSISQLEQTSSKHEQLIAMVMVSFWGISLIASIYLARMSVKPLLESIQKQKAFVE
NASHELRTPLAVLQSRLETLFRKPEATIMQSSENIASSLDEVRNMRLLTTNLLNLARRDDGIKPQYGEVEPEFFDTTFAN
YCIIARENKKAFHSENMIKHPIVTDQIFLKQLMTILFDNAIKYTDDDGVISVMATSTDRYLIFRVADNGPGISDEDKKKI
FDRFYRVDKARTRQKGGFGLGLSLAKQIVDAFKGTIYVKDNKPKGTVFEVKLLLKETKKRSVK

Nucleotide


Download         Length: 1392 bp        

>NTDB_id=1137702 DQM73_RS04835 WP_002925091.1 978322..979713(+) (ciaH) [Streptococcus sanguinis strain NCTC11085]
ATGCTGAATAAAATCAAGAAGACCTTTTATGCGGATGATTTCTCTTATTTCATTCGCTATTTTGGGTTGTTTACATTAAT
CTTCTCAGCCATGACCTTGATTATTATTCAGGTTATGCGCTCCAGCCTTTATACGTCAGTTGATGAAAATCTGAAAAACC
TGAGTAATGATCCTAGTTCAGTAGCTGATTTGGCCTATCGAACGACAGGTCAGCAGTCTGATCCGAGCAATAAGGTCAAT
ACTAAAAGTCCCAAAAACAATAAAGAGCCAGATGGTGATTCAGATGAAGAGCCTAAGCCTAACAATCTAACTACGCCAAA
TGTCAGCTCTAATACCTTTGCCCTGCTTTTGGATGATGATTATAAAAATATTTCCACCAGTAAGAGCGATGGTTTTCTGG
ACTTTAACTCGCTGGAATTTAACAAGTCCTATCTGAATCAAATCAAGGAAATCGTGATTGGTAATAGCTTTGGCCAGACA
GAAAGCTATCGGGCTTATCTCTTTGATATTGATCCTAAAAATGAGTATCCTGATATCAAGTATGCTGTGGTCATGACTAG
TATCAGCCAGCTGGAGCAGACCAGCAGCAAGCATGAGCAGTTGATTGCCATGGTTATGGTCAGCTTTTGGGGAATTTCCC
TGATTGCCAGTATTTACCTTGCTCGGATGAGTGTCAAGCCTCTGCTGGAAAGTATCCAGAAGCAGAAGGCTTTCGTGGAA
AATGCCAGTCACGAACTACGGACTCCTCTGGCAGTATTGCAGAGCCGTTTAGAAACGCTCTTTCGTAAGCCTGAAGCTAC
AATAATGCAGAGCAGTGAAAATATTGCTTCTAGCTTGGATGAAGTACGGAATATGCGCTTGCTGACGACCAATCTGCTCA
ATCTGGCCCGTCGCGATGATGGCATTAAGCCTCAATATGGTGAAGTTGAACCAGAATTTTTTGATACGACCTTTGCTAAT
TACTGCATTATCGCAAGGGAGAATAAAAAAGCTTTTCATTCAGAAAATATGATCAAGCACCCTATTGTGACCGATCAAAT
TTTTCTCAAACAACTGATGACTATTCTATTTGACAATGCTATCAAGTATACAGATGATGATGGCGTAATCAGTGTCATGG
CTACTTCGACAGATCGTTACCTTATTTTCCGAGTGGCGGACAATGGCCCTGGTATCAGCGATGAAGATAAGAAGAAGATT
TTTGATCGTTTTTATCGGGTGGACAAGGCTCGGACCCGTCAGAAAGGTGGCTTTGGTCTGGGACTTTCTCTGGCCAAGCA
GATTGTCGATGCTTTCAAGGGCACCATTTATGTCAAGGACAACAAACCAAAAGGTACGGTCTTTGAAGTTAAACTGCTAT
TGAAAGAAACGAAAAAGCGTTCTGTAAAATAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(236-301)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(344-454)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X3VAS7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

60.954

99.568

0.607
  ciaH Streptococcus pneumoniae D39

60.954

99.568

0.607
  ciaH Streptococcus pneumoniae R6

60.954

99.568

0.607
  ciaH Streptococcus pneumoniae TIGR4

60.954

99.568

0.607
  ciaH Streptococcus mutans UA159

52.412

98.488

0.516

Multiple sequence alignment