Detailed information NTG1137696

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: DQM73_RS03645
• Genome accession: NZ_LS483346
• Coordinates: 698344..700584 (+)
• Length: 746 a.a.
• NCBI ID: WP_002925496.1
• Uniprot ID: A0A2X3UYX6
• Organism: Streptococcus sanguinis strain NCTC11085
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 693344..705584

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM73_RS03625 (NCTC11085_00704)	-	693674..696013 (-)	2340	WP_002934841.1	cation-translocating P-type ATPase	-
DQM73_RS03630 (NCTC11085_00705)	-	696171..696911 (+)	741	WP_002925501.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
DQM73_RS03635 (NCTC11085_00706)	-	696984..697532 (+)	549	WP_172455810.1	HXXEE domain-containing protein	-
DQM73_RS03640 (NCTC11085_00707)	comEA	697680..698360 (+)	681	WP_032908211.1	helix-hairpin-helix domain-containing protein	Machinery gene
DQM73_RS03645 (NCTC11085_00708)	comEC/celB	698344..700584 (+)	2241	WP_002925496.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
DQM73_RS03650 (NCTC11085_00709)	-	700709..701845 (+)	1137	WP_002925494.1	DUF805 domain-containing protein	-
DQM73_RS03655 (NCTC11085_00710)	holA	702097..703143 (+)	1047	WP_032908210.1	DNA polymerase III subunit delta	-
DQM73_RS03660 (NCTC11085_00711)	sodA	703206..703811 (+)	606	WP_002896081.1	superoxide dismutase SodA	-
DQM73_RS03665 (NCTC11085_00712)	-	703947..705026 (+)	1080	WP_002934461.1	serine hydrolase	-
DQM73_RS03670 (NCTC11085_00713)	-	705237..705377 (+)	141	WP_002897970.1	hypothetical protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84910.18 Da
• Isoelectric Point: 9.1567

>NTDB_id=1137696 DQM73_RS03645 WP_002925496.1 698344..700584(+) (comEC/celB) [Streptococcus sanguinis strain NCTC11085]
MLQWIKKLPLAPIYLAFILVWAYFAVYSGSSLAYFGLGVLLLRLFFSYPLKKSLAALAFLSLFVLFFLLRREMAEQAIRR
EPPSASSVQVLPDTIKVNGDSLSFRGRTDGRLYQVFYKIKSASEKEAFQQLTDLVVLDIEAEFEQAQQQRNFSGFDYQAY
LKSQGIYRTLKINKIQSLRSISSLNPLDWLSVWRRKALVYIRSNFPSPMSHYMTGLLFGDLDTEFSEMSNLYSSLGIIHL
FALSGMQVGFFLDGFRRILLRLGMKRETVNALQLPLSFIYAGLTGFSVSVVRSLVQKLLAQQGLTRLDNFALTLMILFII
MPNFLLTAGGVLSCAYAFLISMMDFEKLPPIRKLLTESLTISLGILPILIYYFAEFQPRSVLLTFLFSLLFDLLMLPGLT
LIFILSPLIKISQVNFFFELLEGVIRWVADFTPRPLIFGKPNLWLLAALLLVLALIYDFRRKKSWLLSFILLALLLFFLT
KHPLQNEITVVDIGQGDSIFLRDWQGRTILIDVGGRVEIGKKEAWQERQTSSNAEKTLIPYLKSRGVASLDVLVLTHTDT
DHMGDMLEVAQHFSIKEIYVSKGSLTQPDFVQKLEQIESSVHVVEVGDEIPVFDSALQVLYPSGTGDGGNDDSIVLYGEF
FQTKFLFTGDLERQGEIELLQRFPQLKADVLKAGHHGSKGSSSPEFLEQIQPKLALISAGQNNRYRHPHQETLQRFEKFN
TTIYRTDQQGAIRLIGWNSWRIETVH

Nucleotide

• Length: 2241 bp

>NTDB_id=1137696 DQM73_RS03645 WP_002925496.1 698344..700584(+) (comEC/celB) [Streptococcus sanguinis strain NCTC11085]
ATGTTACAGTGGATTAAAAAGTTACCCCTCGCCCCTATCTACTTGGCTTTCATCCTTGTCTGGGCCTATTTTGCAGTCTA
TTCTGGCAGTTCCTTGGCTTATTTTGGGCTGGGTGTCCTTCTGCTTCGTCTCTTTTTCAGCTATCCTCTCAAAAAAAGTC
TAGCTGCCTTGGCATTTCTGTCCCTTTTTGTCCTCTTTTTCTTGCTTCGTCGGGAAATGGCAGAGCAGGCCATTAGGCGG
GAACCTCCTTCAGCTAGCTCGGTTCAGGTCTTGCCGGATACGATCAAAGTCAATGGAGATTCCCTATCCTTTCGAGGGCG
AACGGACGGTCGGCTTTATCAAGTCTTCTACAAGATTAAATCAGCCAGTGAAAAGGAAGCTTTTCAGCAACTGACAGATT
TGGTCGTCCTTGATATTGAAGCAGAGTTTGAACAGGCCCAGCAGCAACGAAATTTTTCGGGCTTTGACTATCAGGCTTAT
TTAAAGAGTCAGGGGATTTATCGTACCTTAAAAATCAATAAGATTCAGTCACTAAGATCAATTTCCAGCCTGAATCCACT
GGATTGGCTGTCTGTCTGGCGCAGAAAAGCGCTGGTCTATATTCGAAGTAATTTTCCTAGTCCAATGAGCCATTACATGA
CAGGACTCTTGTTTGGTGACTTGGATACGGAGTTTTCGGAAATGAGCAATCTGTATTCTAGCTTGGGTATCATCCACTTG
TTTGCCTTGTCTGGTATGCAGGTAGGTTTCTTTTTGGATGGTTTTCGCAGGATTCTTCTACGTTTGGGGATGAAGAGGGA
GACAGTAAACGCCTTGCAGCTGCCTCTTTCATTTATCTATGCTGGACTGACGGGCTTTTCTGTTTCTGTCGTCAGAAGCT
TAGTTCAGAAATTGTTGGCCCAGCAAGGATTGACCAGATTAGATAATTTTGCTCTGACACTGATGATTCTCTTTATCATC
ATGCCCAATTTTCTTCTGACAGCAGGCGGTGTCTTGTCCTGCGCCTATGCCTTTTTGATTTCTATGATGGATTTTGAAAA
GTTACCGCCGATTCGGAAGCTTTTAACGGAAAGTCTGACTATTTCATTGGGGATTTTGCCTATACTAATCTACTACTTTG
CAGAATTTCAGCCTCGGTCCGTACTTCTGACTTTTCTATTTTCACTACTCTTTGACCTGCTGATGCTGCCAGGCTTAACC
CTCATTTTTATTTTGTCACCACTTATAAAAATCTCTCAGGTCAATTTTTTCTTTGAGTTACTTGAAGGTGTGATTCGTTG
GGTAGCTGACTTTACTCCGCGCCCTTTGATTTTTGGGAAACCCAACCTCTGGTTACTGGCCGCTCTGCTTTTGGTTTTAG
CTTTAATCTATGACTTTCGGAGAAAGAAAAGCTGGCTTTTATCTTTTATTTTGCTAGCTCTTCTCTTATTTTTCCTAACA
AAGCATCCGCTGCAAAATGAGATTACAGTGGTGGATATTGGTCAGGGGGATAGCATTTTTCTCCGGGACTGGCAGGGCAG
GACGATTTTGATTGACGTTGGAGGGCGAGTCGAGATAGGAAAGAAGGAGGCTTGGCAGGAGCGACAGACTTCATCCAATG
CAGAAAAGACCTTAATTCCCTATCTTAAAAGCCGTGGCGTTGCTAGTTTGGATGTATTGGTCCTGACTCATACCGATACC
GACCACATGGGCGATATGCTGGAGGTAGCTCAGCATTTTTCTATCAAGGAAATCTACGTTTCCAAAGGAAGTCTCACTCA
GCCTGATTTTGTTCAAAAGCTGGAGCAGATAGAAAGTTCTGTCCATGTCGTAGAAGTGGGAGATGAGATTCCGGTATTTG
ACTCAGCTTTGCAGGTTCTCTATCCTAGTGGGACAGGCGACGGTGGAAATGATGATTCGATTGTACTCTACGGGGAGTTC
TTTCAGACAAAATTTTTGTTTACAGGTGATTTGGAAAGGCAGGGAGAAATTGAACTGCTGCAGCGATTCCCTCAGCTGAA
AGCAGATGTCTTAAAAGCAGGACACCATGGCTCCAAAGGCTCTTCCAGTCCAGAGTTTTTAGAGCAAATTCAGCCGAAAC
TGGCCTTGATATCAGCTGGCCAGAATAATCGTTATCGACATCCGCATCAGGAAACTTTGCAAAGATTTGAGAAGTTTAAT
ACAACCATCTATCGAACTGACCAGCAGGGGGCCATTCGTTTGATTGGTTGGAATTCCTGGAGGATTGAAACAGTTCATTG
A

Domains

Predicted by InterproScan.

• Competence protein (Competence) (216-461)

• Metallo-beta-lactamase superfamily (Lactamase_B) (494-700)

3D structure

• AlphaFold DB: A0A2X3UYX6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	57.831	100	0.579
comEC/celB	Streptococcus mitis NCTC 12261	57.373	100	0.574
comEC/celB	Streptococcus pneumoniae TIGR4	56.76	100	0.568
comEC/celB	Streptococcus pneumoniae D39	56.627	100	0.567
comEC/celB	Streptococcus pneumoniae Rx1	56.627	100	0.567
comEC/celB	Streptococcus pneumoniae R6	56.627	100	0.567
comEC	Lactococcus lactis subsp. cremoris KW2	48.461	100	0.485