Detailed information NTG1137597

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: DQL21_RS04475
• Genome accession: NZ_LS483343
• Coordinates: 856861..857532 (+)
• Length: 223 a.a.
• NCBI ID: WP_018029743.1
• Uniprot ID: A0A2X3VFR6
• Organism: Streptococcus ferus strain NCTC12278
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 851861..862532

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL21_RS04450 (NCTC12278_00880)	phoU	851908..852561 (+)	654	WP_018029737.1	phosphate signaling complex protein PhoU	-
DQL21_RS04455 (NCTC12278_00881)	-	852595..855138 (+)	2544	WP_018029738.1	M1 family metallopeptidase	-
DQL21_RS04460 (NCTC12278_00882)	-	855181..855831 (-)	651	WP_018029739.1	hemolysin III family protein	-
DQL21_RS04465 (NCTC12278_00883)	-	855828..856268 (-)	441	WP_018029740.1	DUF1836 domain-containing protein	-
DQL21_RS04470 (NCTC12278_00885)	-	856543..856812 (+)	270	WP_018029742.1	hypothetical protein	-
DQL21_RS04475 (NCTC12278_00886)	ciaR	856861..857532 (+)	672	WP_018029743.1	response regulator transcription factor	Regulator
DQL21_RS04480 (NCTC12278_00887)	ciaH	857525..858838 (+)	1314	WP_018029744.1	cell wall metabolism sensor histidine kinase WalK	Regulator
DQL21_RS04485 (NCTC12278_00888)	rpsT	858956..859207 (-)	252	WP_026161880.1	30S ribosomal protein S20	-
DQL21_RS04490 (NCTC12278_00889)	coaA	859260..860180 (-)	921	WP_018029746.1	type I pantothenate kinase	-
DQL21_RS04495 (NCTC12278_00890)	-	860294..860884 (+)	591	WP_018029747.1	class I SAM-dependent methyltransferase	-
DQL21_RS04500 (NCTC12278_00891)	-	860871..862148 (+)	1278	WP_018029748.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25567.27 Da
• Isoelectric Point: 4.2802

>NTDB_id=1137597 DQL21_RS04475 WP_018029743.1 856861..857532(+) (ciaR) [Streptococcus ferus strain NCTC12278]
MIKILLVEDDLNLSNSVFDFLDDFADVMQVFDGDEGLYEAESNVYDLILLDLMLPEKNGFQLLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNLTVDLATNTVNIDQQEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKVRKKLKDTDFGRNLQTLRSVGYILKNV

Nucleotide

• Length: 672 bp

>NTDB_id=1137597 DQL21_RS04475 WP_018029743.1 856861..857532(+) (ciaR) [Streptococcus ferus strain NCTC12278]
ATGATAAAAATCTTATTAGTGGAAGATGATTTAAACCTGTCAAATTCTGTTTTTGACTTTCTAGATGACTTTGCCGATGT
GATGCAAGTATTCGATGGTGACGAAGGGCTTTACGAAGCTGAGAGTAATGTCTATGACTTAATCTTGCTGGATCTGATGC
TGCCTGAAAAAAATGGTTTCCAGCTACTTAAAGAACTCCGTGAAAAAGGAATCACGACGCCTGTTCTGATTATGACCGCT
AAGGAAAGCCTAGATGATAAGGGGCATGGTTTTGAGCTAGGAGCAGATGACTACCTAACCAAACCCTTTTATCTAGAAGA
ATTAAAAATGCGTATTCAGGCCTTGCTGAAACGTTCAGGAAAATTTAACGAAAATACTTTGACTTACGGGAATCTGACTG
TTGATTTGGCAACCAATACCGTCAATATTGACCAGCAAGAAGTTGAATTGCTGGGGAAGGAATTTGATTTATTGGTATAT
TTTCTGCAGAATCAGAATGTTATCTTGCCAAAGTCTCAGATTTTCGACCGTATTTGGGGCTTTGACAGCGATACGACTAT
TTCAGTTGTTGAAGTTTATGTTTCCAAGGTTCGTAAAAAGCTTAAAGATACTGATTTTGGCAGAAACTTGCAGACCTTAA
GAAGTGTAGGGTATATCTTAAAAAATGTTTGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A2X3VFR6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.583	100	0.906
ciaR	Streptococcus pneumoniae Rx1	90.135	100	0.901
ciaR	Streptococcus pneumoniae D39	90.135	100	0.901
ciaR	Streptococcus pneumoniae R6	90.135	100	0.901
ciaR	Streptococcus pneumoniae TIGR4	90.135	100	0.901
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.333	100	0.377
vicR	Streptococcus mutans UA159	35.043	100	0.368