Detailed information NTG1136971

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: DQM36_RS04475
• Genome accession: NZ_LS483332
• Coordinates: 863053..863889 (+)
• Length: 278 a.a.
• NCBI ID: WP_011054501.1
• Uniprot ID: A0A5S4TKN4
• Organism: Streptococcus pyogenes strain NCTC12696
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 858053..868889

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM36_RS04445 (NCTC12696_00870)	-	858538..858975 (+)	438	WP_032465020.1	hypothetical protein	-
DQM36_RS04450 (NCTC12696_00871)	-	859025..859936 (-)	912	WP_023610321.1	diacylglycerol/lipid kinase family protein	-
DQM36_RS04455 (NCTC12696_00872)	trhA	860053..860703 (-)	651	WP_002984629.1	PAQR family membrane homeostasis protein TrhA	-
DQM36_RS04460 (NCTC12696_00873)	-	860700..861140 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
DQM36_RS04465 (NCTC12696_00874)	ylqF	861359..862207 (+)	849	WP_023610309.1	ribosome biogenesis GTPase YlqF	-
DQM36_RS04470 (NCTC12696_00875)	-	862197..862988 (+)	792	WP_023610315.1	ribonuclease HII	-
DQM36_RS04475 (NCTC12696_00876)	dprA	863053..863889 (+)	837	WP_011054501.1	DNA-processing protein DprA	Machinery gene
DQM36_RS04480 (NCTC12696_00877)	topA	863997..866126 (+)	2130	WP_023610295.1	type I DNA topoisomerase	-
DQM36_RS04485 (NCTC12696_00878)	trmFO	866261..867607 (+)	1347	WP_023610318.1	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31087.14 Da
• Isoelectric Point: 9.4248

>NTDB_id=1136971 DQM36_RS04475 WP_011054501.1 863053..863889(+) (dprA) [Streptococcus pyogenes strain NCTC12696]
MNHFELYKLKKAGLTNKNILNILDYQKHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=1136971 DQM36_RS04475 WP_011054501.1 863053..863889(+) (dprA) [Streptococcus pyogenes strain NCTC12696]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAAA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCTGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

3D structure

• AlphaFold DB: A0A5S4TKN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.266	100	0.673
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.072	100	0.601
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.072	100	0.601
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.072	100	0.601
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.072	100	0.601
dprA/cilB/dalA	Streptococcus mitis SK321	60.072	100	0.601
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	59.712	100	0.597
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367