Detailed information NTG1136914

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: DQL10_RS04515
• Genome accession: NZ_LS483331
• Coordinates: 881771..882607 (+)
• Length: 278 a.a.
• NCBI ID: WP_023611998.1
• Uniprot ID: A0A5S4TFX7
• Organism: Streptococcus pyogenes strain NCTC12057
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 876771..887607

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL10_RS04485 (NCTC12057_00885)	-	877325..877693 (+)	369	WP_010922310.1	hypothetical protein	-
DQL10_RS04490 (NCTC12057_00886)	-	877743..878654 (-)	912	WP_023612012.1	diacylglycerol/lipid kinase family protein	-
DQL10_RS04495 (NCTC12057_00887)	trhA	878771..879421 (-)	651	WP_002984629.1	PAQR family membrane homeostasis protein TrhA	-
DQL10_RS04500 (NCTC12057_00888)	-	879418..879858 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
DQL10_RS04505 (NCTC12057_00889)	ylqF	880077..880925 (+)	849	WP_023611994.1	ribosome biogenesis GTPase YlqF	-
DQL10_RS04510 (NCTC12057_00890)	-	880915..881706 (+)	792	WP_023612045.1	ribonuclease HII	-
DQL10_RS04515 (NCTC12057_00891)	dprA	881771..882607 (+)	837	WP_023611998.1	DNA-processing protein DprA	Machinery gene
DQL10_RS04520 (NCTC12057_00892)	topA	882715..884844 (+)	2130	WP_050336211.1	type I DNA topoisomerase	-
DQL10_RS09310	-	884919..885803 (-)	885	Protein_826	LysR family transcriptional regulator	-
DQL10_RS04535 (NCTC12057_00894)	-	885816..886382 (+)	567	Protein_827	PTS sugar transporter subunit IIC	-
DQL10_RS04540 (NCTC12057_00895)	-	886397..887389 (+)	993	WP_023612447.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 30958.92 Da
• Isoelectric Point: 8.8230

>NTDB_id=1136914 DQL10_RS04515 WP_023611998.1 881771..882607(+) (dprA) [Streptococcus pyogenes strain NCTC12057]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGAACVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=1136914 DQL10_RS04515 WP_023611998.1 881771..882607(+) (dprA) [Streptococcus pyogenes strain NCTC12057]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCTGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACTGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAATCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACTATC
GCTATTATTGGAACAGGATTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAGGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAGCATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A5S4TFX7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis SK321	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.432	100	0.604
dprA	Lactococcus lactis subsp. cremoris KW2	57.554	100	0.576
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367