Detailed information
Bioinformatically predicted
Overview
| Name | dprA | Type | Machinery gene |
| Locus tag | DQL07_RS04440 | Genome accession | NZ_LS483327 |
| Coordinates | 849183..850019 (+) | Length | 278 a.a. |
| NCBI ID | WP_111702859.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain NCTC12069 | ||
| Function | ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 846992..920914 | 849183..850019 | within | 0 |
Gene organization within MGE regions
Location: 846992..920914
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQL07_RS04430 (NCTC12069_00869) | ylqF | 847489..848337 (+) | 849 | WP_002984625.1 | ribosome biogenesis GTPase YlqF | - |
| DQL07_RS04435 (NCTC12069_00870) | - | 848327..849118 (+) | 792 | WP_011888871.1 | ribonuclease HII | - |
| DQL07_RS04440 (NCTC12069_00871) | dprA | 849183..850019 (+) | 837 | WP_111702859.1 | DNA-processing protein DprA | Machinery gene |
| DQL07_RS04445 (NCTC12069_00872) | topA | 850126..852255 (+) | 2130 | WP_002984618.1 | type I DNA topoisomerase | - |
| DQL07_RS04450 (NCTC12069_00873) | trmFO | 852390..853736 (+) | 1347 | WP_021733693.1 | methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO | - |
| DQL07_RS04455 (NCTC12069_00874) | - | 853892..855295 (+) | 1404 | WP_280529077.1 | pyruvate carboxylase subunit B | - |
| DQL07_RS04460 (NCTC12069_00875) | - | 855338..855652 (+) | 315 | WP_009881173.1 | membrane protein | - |
| DQL07_RS04465 (NCTC12069_00876) | - | 855652..856002 (+) | 351 | WP_111702860.1 | biotin/lipoyl-containing protein | - |
| DQL07_RS04470 (NCTC12069_00877) | - | 856012..857142 (+) | 1131 | WP_002995027.1 | sodium ion-translocating decarboxylase subunit beta | - |
| DQL07_RS04475 (NCTC12069_00878) | citG | 857343..858227 (-) | 885 | WP_011284803.1 | triphosphoribosyl-dephospho-CoA synthase CitG | - |
| DQL07_RS04480 (NCTC12069_00879) | - | 858220..858915 (-) | 696 | WP_002995032.1 | GntR family transcriptional regulator | - |
| DQL07_RS04485 (NCTC12069_00880) | - | 859073..860476 (-) | 1404 | WP_014635470.1 | CitMHS family transporter | - |
| DQL07_RS04490 (NCTC12069_00881) | - | 860856..861179 (+) | 324 | WP_014635471.1 | hypothetical protein | - |
| DQL07_RS04495 (NCTC12069_00882) | - | 861236..861631 (+) | 396 | WP_002991764.1 | acetyl-CoA carboxylase biotin carboxyl carrier protein subunit | - |
| DQL07_RS04500 (NCTC12069_00883) | - | 861676..862797 (+) | 1122 | WP_002991766.1 | sodium ion-translocating decarboxylase subunit beta | - |
| DQL07_RS09635 (NCTC12069_00884) | - | 862815..862949 (+) | 135 | WP_002991768.1 | OadG-related small transporter subunit | - |
| DQL07_RS04505 (NCTC12069_00885) | citD | 862985..863293 (+) | 309 | WP_002991770.1 | citrate lyase acyl carrier protein | - |
| DQL07_RS04510 (NCTC12069_00886) | citE | 863281..864168 (+) | 888 | WP_111702861.1 | citrate (pro-3S)-lyase subunit beta | - |
| DQL07_RS04515 (NCTC12069_00887) | citF | 864171..865703 (+) | 1533 | WP_002984610.1 | citrate lyase subunit alpha | - |
| DQL07_RS04520 (NCTC12069_00888) | citX | 865696..866274 (+) | 579 | WP_011054513.1 | citrate lyase holo-[acyl-carrier protein] synthase | - |
| DQL07_RS04525 (NCTC12069_00889) | - | 866289..867683 (+) | 1395 | WP_014635474.1 | oxaloacetate decarboxylase subunit alpha | - |
| DQL07_RS04530 (NCTC12069_00890) | citC | 867793..868845 (-) | 1053 | WP_111702862.1 | [citrate (pro-3S)-lyase] ligase | - |
| DQL07_RS04535 (NCTC12069_00891) | - | 868934..869416 (-) | 483 | WP_002984600.1 | PASTA domain-containing protein | - |
| DQL07_RS04540 (NCTC12069_00892) | xerS | 870115..871185 (-) | 1071 | WP_002984598.1 | tyrosine recombinase XerS | - |
| DQL07_RS04545 (NCTC12069_00893) | - | 871655..872353 (+) | 699 | WP_014635476.1 | XRE family transcriptional regulator | - |
| DQL07_RS04550 (NCTC12069_00894) | ffh | 872488..874050 (-) | 1563 | WP_111702863.1 | signal recognition particle protein | - |
| DQL07_RS04555 (NCTC12069_00895) | - | 874065..874397 (-) | 333 | WP_002989745.1 | putative DNA-binding protein | - |
| DQL07_RS04560 (NCTC12069_00896) | - | 874495..875193 (-) | 699 | WP_002989743.1 | GntR family transcriptional regulator | - |
| DQL07_RS04565 (NCTC12069_00897) | - | 875276..876709 (-) | 1434 | WP_011017793.1 | hypothetical protein | - |
| DQL07_RS04570 (NCTC12069_00898) | guaA | 876876..878438 (+) | 1563 | WP_002993734.1 | glutamine-hydrolyzing GMP synthase | - |
| DQL07_RS04575 (NCTC12069_00899) | - | 878506..879699 (-) | 1194 | WP_000237798.1 | site-specific integrase | - |
| DQL07_RS04580 (NCTC12069_00900) | - | 879726..879926 (-) | 201 | WP_000633909.1 | DUF3173 domain-containing protein | - |
| DQL07_RS04590 (NCTC12069_00901) | - | 880422..880652 (-) | 231 | WP_000845144.1 | helix-turn-helix domain-containing protein | - |
| DQL07_RS04595 (NCTC12069_00902) | - | 880649..881071 (-) | 423 | WP_000804878.1 | RNA polymerase sigma factor | - |
| DQL07_RS04600 (NCTC12069_00903) | - | 881603..881956 (+) | 354 | WP_001227349.1 | helix-turn-helix transcriptional regulator | - |
| DQL07_RS04605 | - | 882014..882199 (-) | 186 | WP_413926387.1 | cysteine-rich KTR domain-containing protein | - |
| DQL07_RS04610 (NCTC12069_00904) | tet(M) | 882300..884219 (-) | 1920 | WP_111702864.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| DQL07_RS09750 | - | 884235..884282 (-) | 48 | Protein_841 | hypothetical protein | - |
| DQL07_RS04625 (NCTC12069_00905) | - | 884596..885525 (-) | 930 | WP_000584387.1 | conjugal transfer protein | - |
| DQL07_RS04630 (NCTC12069_00906) | - | 885542..886564 (-) | 1023 | WP_000768374.1 | bifunctional lytic transglycosylase/C40 family peptidase | - |
| DQL07_RS04635 (NCTC12069_00907) | - | 886561..888588 (-) | 2028 | WP_000192390.1 | CD3337/EF1877 family mobilome membrane protein | - |
| DQL07_RS04640 (NCTC12069_00908) | - | 888585..891038 (-) | 2454 | WP_000941001.1 | ATP-binding protein | - |
| DQL07_RS04645 (NCTC12069_00909) | - | 891022..891417 (-) | 396 | WP_000723886.1 | conjugal transfer protein | - |
| DQL07_RS04650 (NCTC12069_00910) | - | 891488..892513 (-) | 1026 | WP_000234705.1 | hypothetical protein | - |
| DQL07_RS04655 (NCTC12069_00911) | - | 892585..893085 (-) | 501 | WP_000421245.1 | antirestriction protein ArdA | - |
| DQL07_RS04660 (NCTC12069_00912) | - | 893147..893926 (-) | 780 | WP_000678782.1 | abortive infection family protein | - |
| DQL07_RS04665 (NCTC12069_00913) | - | 893968..894189 (-) | 222 | WP_001009054.1 | hypothetical protein | - |
| DQL07_RS04670 (NCTC12069_00914) | - | 894186..894458 (-) | 273 | WP_002388720.1 | hypothetical protein | - |
| DQL07_RS04675 (NCTC12069_00915) | mobT | 894455..895639 (-) | 1185 | WP_002388719.1 | MobT family relaxase | - |
| DQL07_RS04680 (NCTC12069_00916) | - | 895821..897224 (-) | 1404 | WP_111702865.1 | FtsK/SpoIIIE domain-containing protein | - |
| DQL07_RS04685 (NCTC12069_00917) | - | 897246..898019 (-) | 774 | WP_000185760.1 | hypothetical protein | - |
| DQL07_RS04690 (NCTC12069_00918) | - | 898029..898406 (-) | 378 | WP_001234189.1 | YdcP family protein | - |
| DQL07_RS04695 (NCTC12069_00919) | - | 898427..898741 (-) | 315 | WP_000421280.1 | YdcP family protein | - |
| DQL07_RS04700 (NCTC12069_00920) | - | 899090..900313 (-) | 1224 | WP_020905214.1 | aminoacyltransferase | - |
| DQL07_RS04705 (NCTC12069_00921) | - | 900678..902222 (-) | 1545 | WP_002992576.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| DQL07_RS04710 (NCTC12069_00922) | - | 902356..902913 (-) | 558 | WP_002989733.1 | ECF transporter S component | - |
| DQL07_RS04715 (NCTC12069_00923) | - | 902891..903757 (-) | 867 | WP_002992577.1 | pyridoxamine kinase | - |
| DQL07_RS04720 (NCTC12069_00924) | - | 903847..905115 (+) | 1269 | WP_011054517.1 | PLP-dependent aminotransferase family protein | - |
| DQL07_RS04725 (NCTC12069_00925) | - | 905586..905924 (-) | 339 | WP_002989726.1 | ATP cone domain-containing protein | - |
| DQL07_RS04730 (NCTC12069_00927) | cls | 906263..907840 (-) | 1578 | WP_011054518.1 | cardiolipin synthase | - |
| DQL07_RS04735 (NCTC12069_00928) | - | 907925..909595 (-) | 1671 | WP_002989724.1 | formate--tetrahydrofolate ligase | - |
| DQL07_RS04740 (NCTC12069_00929) | - | 909723..910742 (-) | 1020 | WP_002984559.1 | lipoate--protein ligase | - |
| DQL07_RS04745 (NCTC12069_00930) | - | 910789..911670 (-) | 882 | WP_002992884.1 | SIR2 family NAD-dependent protein deacylase | - |
| DQL07_RS04750 (NCTC12069_00931) | - | 911663..912475 (-) | 813 | WP_009880444.1 | protein-ADP-ribose hydrolase | - |
| DQL07_RS04755 (NCTC12069_00932) | - | 912468..912800 (-) | 333 | WP_002984553.1 | glycine cleavage system protein H | - |
| DQL07_RS04760 (NCTC12069_00933) | - | 912842..913840 (-) | 999 | WP_009880445.1 | LLM class flavin-dependent oxidoreductase | - |
| DQL07_RS04765 (NCTC12069_00934) | - | 913837..915036 (-) | 1200 | WP_002992890.1 | NADH-dependent flavin oxidoreductase | - |
| DQL07_RS04770 (NCTC12069_00935) | - | 915033..915869 (-) | 837 | WP_052316792.1 | biotin/lipoate A/B protein ligase family protein | - |
| DQL07_RS04775 (NCTC12069_00936) | coaB | 916071..916757 (+) | 687 | WP_002992894.1 | phosphopantothenate--cysteine ligase | - |
| DQL07_RS04780 (NCTC12069_00937) | coaC | 916750..917295 (+) | 546 | WP_047235268.1 | phosphopantothenoylcysteine decarboxylase | - |
| DQL07_RS04785 (NCTC12069_00938) | - | 917353..917922 (+) | 570 | WP_002984543.1 | ECF transporter S component | - |
| DQL07_RS04790 (NCTC12069_00939) | - | 918098..919816 (+) | 1719 | WP_002992949.1 | phospho-sugar mutase | - |
Sequence
Protein
Download Length: 278 a.a. Molecular weight: 30928.87 Da Isoelectric Point: 9.0514
>NTDB_id=1136690 DQL07_RS04440 WP_111702859.1 849183..850019(+) (dprA) [Streptococcus pyogenes strain NCTC12069]
MNHFELYKLKKAGLTNKNILNILDYQEHQGKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKIEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSSMDILSEY
MNHFELYKLKKAGLTNKNILNILDYQEHQGKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKIEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSSMDILSEY
Nucleotide
Download Length: 837 bp
>NTDB_id=1136690 DQL07_RS04440 WP_111702859.1 849183..850019(+) (dprA) [Streptococcus pyogenes strain NCTC12069]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGGAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATAGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAATCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAGGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGTCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGAGCATGGATATCCTTTCAGAGTACTAA
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGGAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATAGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAATCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAGGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGTCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGAGCATGGATATCCTTTCAGAGTACTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| dprA | Streptococcus mutans UA159 |
67.266 |
100 |
0.673 |
| dprA/cilB/dalA | Streptococcus pneumoniae Rx1 |
60.432 |
100 |
0.604 |
| dprA/cilB/dalA | Streptococcus pneumoniae D39 |
60.432 |
100 |
0.604 |
| dprA/cilB/dalA | Streptococcus pneumoniae R6 |
60.432 |
100 |
0.604 |
| dprA/cilB/dalA | Streptococcus pneumoniae TIGR4 |
60.432 |
100 |
0.604 |
| dprA/cilB/dalA | Streptococcus mitis SK321 |
60.432 |
100 |
0.604 |
| dprA/cilB/dalA | Streptococcus mitis NCTC 12261 |
60.072 |
100 |
0.601 |
| dprA | Lactococcus lactis subsp. cremoris KW2 |
57.554 |
100 |
0.576 |
| dprA | Legionella pneumophila strain ERS1305867 |
42.857 |
85.612 |
0.367 |