Detailed information NTG1136602

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DQL35_RS10545
• Genome accession: NZ_LS483325
• Coordinates: 2169839..2171062 (+)
• Length: 407 a.a.
• NCBI ID: WP_111678804.1
• Uniprot ID: A0A380JVF3
• Organism: Streptococcus equi subsp. zooepidemicus strain NCTC7022
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2164839..2176062

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL35_RS10520 (NCTC7022_02125)	-	2165534..2168119 (+)	2586	WP_111678803.1	YfhO family protein	-
DQL35_RS10540 (NCTC7022_02129)	rlmH	2169150..2169629 (-)	480	WP_037579263.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQL35_RS10545 (NCTC7022_02130)	htrA	2169839..2171062 (+)	1224	WP_111678804.1	S1C family serine protease	Regulator
DQL35_RS10550 (NCTC7022_02131)	spo0J	2171181..2171954 (+)	774	WP_111678805.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42508.13 Da
• Isoelectric Point: 5.8380

>NTDB_id=1136602 DQL35_RS10545 WP_111678804.1 2169839..2171062(+) (htrA) [Streptococcus equi subsp. zooepidemicus strain NCTC7022]
MLKSKNILKPLWVLVIGFLGGLLAALVVNGFSQNSLTSSNAKGATTTSNVSFNNTTDTTKAVKVVQDAVVSVINYQKAAS
PTISNPYINLFGEENDTSAVQKEDELSIHSEGSGVVYKKEGNTAYLVTNNHVIEGAQRIEILTADGSKIVGELVGADTYS
DLAVVKIAADKIKTIAKFADSTKINVGEVAIAIGSPLGTKYANSVTEGIVSSLSRTVTSRNEAGETISTNAIQTDAAINP
GNSGGPLINIEGQVIGINSSKISSTPTGSGGAIEGIGFAIPSSDVVTIINQLESNGAVIRPALGITMVNLSNLSTSALIQ
LNIPTSVTSGVVVASTQNSMPALGKLEQYDVITEVDGKEVSSISDLQSVLYSHEINDTIKVTFYRGTAKKKVDIKLTKTT
KDLTKKQ

Nucleotide

• Length: 1224 bp

>NTDB_id=1136602 DQL35_RS10545 WP_111678804.1 2169839..2171062(+) (htrA) [Streptococcus equi subsp. zooepidemicus strain NCTC7022]
GTGTTAAAATCAAAAAATATATTGAAGCCCTTATGGGTTTTAGTCATTGGATTTTTAGGGGGCTTATTAGCTGCCTTAGT
TGTTAACGGATTTAGTCAGAATTCTCTAACATCTTCAAATGCAAAGGGAGCAACGACAACAAGCAACGTCAGCTTTAACA
ATACAACTGATACAACAAAAGCTGTTAAGGTGGTTCAAGATGCTGTAGTGTCTGTTATTAACTATCAAAAGGCTGCTTCG
CCTACTATTTCAAATCCTTACATCAATCTTTTTGGAGAAGAAAATGACACCTCAGCGGTACAAAAAGAGGACGAGCTAAG
CATACACAGTGAAGGCTCCGGTGTTGTTTACAAAAAAGAAGGAAATACCGCTTATCTTGTAACCAACAATCATGTTATTG
AGGGAGCTCAACGAATTGAAATTTTAACAGCAGATGGCTCTAAGATCGTTGGAGAACTAGTTGGTGCAGACACTTATTCT
GACCTAGCTGTTGTCAAAATTGCTGCTGATAAAATCAAAACAATAGCCAAATTTGCAGATTCAACCAAAATCAATGTTGG
AGAGGTAGCCATTGCAATTGGTAGTCCTCTTGGAACCAAATACGCCAACTCAGTGACAGAAGGGATTGTTTCGAGTCTAA
GCCGTACAGTCACTTCAAGAAATGAGGCAGGTGAGACTATCTCAACAAATGCTATCCAAACTGATGCTGCTATCAATCCA
GGTAATTCAGGTGGACCACTCATCAATATTGAAGGTCAGGTCATTGGTATCAACTCAAGTAAAATATCCTCAACACCTAC
TGGCAGCGGCGGAGCCATTGAAGGGATTGGCTTTGCTATTCCATCAAGCGATGTTGTCACCATTATTAACCAACTAGAAT
CTAACGGAGCTGTTATCAGACCAGCCTTAGGCATTACTATGGTAAATCTAAGCAATCTATCAACCAGTGCATTGATTCAA
TTGAACATTCCAACAAGCGTTACCAGTGGTGTTGTCGTAGCTTCTACTCAAAATAGCATGCCAGCTCTTGGCAAATTGGA
GCAGTATGATGTCATTACTGAGGTTGACGGTAAAGAGGTTAGCTCAATCAGTGACCTACAAAGTGTCCTATACAGTCATG
AGATTAACGACACCATTAAGGTAACCTTCTACAGAGGAACTGCTAAGAAAAAAGTTGACATCAAATTAACAAAAACAACT
AAGGATCTAACTAAAAAGCAGTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (112-257)

• PDZ domain (PDZ_2) (301-396)

3D structure

• AlphaFold DB: A0A380JVF3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.52	100	0.617
htrA	Streptococcus gordonii str. Challis substr. CH1	57.855	98.526	0.57
htrA	Streptococcus mitis NCTC 12261	55.416	97.543	0.541
htrA	Streptococcus pneumoniae Rx1	54.386	98.034	0.533
htrA	Streptococcus pneumoniae D39	54.386	98.034	0.533
htrA	Streptococcus pneumoniae R6	54.386	98.034	0.533
htrA	Streptococcus pneumoniae TIGR4	54.386	98.034	0.533