Detailed information NTG1136378

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: DQL06_RS07505
• Genome accession: NZ_LS483321
• Coordinates: 1451174..1453327 (+)
• Length: 717 a.a.
• NCBI ID: WP_111689643.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8314
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1446174..1458327

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL06_RS07460 (NCTC8314_01498)	stcA	1446606..1446875 (+)	270	WP_023605037.1	quorum-sensing system protein StcA	-
DQL06_RS07465 (NCTC8314_01499)	-	1447223..1447621 (-)	399	WP_172448808.1	histidine kinase	-
DQL06_RS07470 (NCTC8314_01500)	-	1447714..1448784 (-)	1071	WP_111689641.1	hypothetical protein	-
DQL06_RS07475 (NCTC8314_01501)	-	1449035..1449436 (-)	402	WP_053308564.1	hypothetical protein	-
DQL06_RS07480 (NCTC8314_01502)	-	1449630..1449911 (-)	282	WP_032466308.1	hypothetical protein	-
DQL06_RS07495 (NCTC8314_01503)	-	1450450..1450650 (-)	201	WP_002985729.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
DQL06_RS07500 (NCTC8314_01504)	-	1450663..1450890 (-)	228	WP_002992018.1	Blp family class II bacteriocin	-
DQL06_RS07505 (NCTC8314_01505)	comA/nlmT	1451174..1453327 (+)	2154	WP_111689643.1	peptide cleavage/export ABC transporter	Regulator
DQL06_RS07510	-	1453338..1454701 (+)	1364	Protein_1406	bacteriocin secretion accessory protein	-
DQL06_RS07515 (NCTC8314_01508)	-	1454778..1454903 (+)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
DQL06_RS09755	comD/blpH	1455051..1455254 (-)	204	WP_331792677.1	GHKL domain-containing protein	Regulator
DQL06_RS09760 (NCTC8314_01509)	-	1455271..1456008 (-)	738	WP_231870884.1	hypothetical protein	-
DQL06_RS07525 (NCTC8314_01510)	comE/blpR	1456387..1457136 (-)	750	WP_030126108.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80663.76 Da
• Isoelectric Point: 7.5350

>NTDB_id=1136378 DQL06_RS07505 WP_111689643.1 1451174..1453327(+) (comA/nlmT) [Streptococcus pyogenes strain NCTC8314]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDCSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILKQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTNEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLESAKVANNRLNEVYLVKSEFQKEQALTDTYCL
YGDIQFADLSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAELSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS

Nucleotide

• Length: 2154 bp

>NTDB_id=1136378 DQL06_RS07505 WP_111689643.1 1451174..1453327(+) (comA/nlmT) [Streptococcus pyogenes strain NCTC8314]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTGCTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAATAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCAAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAGCTTCCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAATGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGGAATCCGCTAAGGTTG
CCAATAATCGGCTTAATGAAGTTTACCTGGTTAAATCTGAGTTCCAAAAAGAACAGGCATTAACAGATACCTATTGTCTA
TATGGAGATATCCAATTTGCAGACTTGTCTTATAAATACGGCTTTGGTCGTGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGAACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-649)

• ABC transporter transmembrane region (ABC_membrane) (168-438)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.028	99.721	0.718
comA	Streptococcus mitis NCTC 12261	66.667	99.582	0.664
comA	Streptococcus mitis SK321	66.246	99.582	0.66
comA	Streptococcus pneumoniae Rx1	66.246	99.582	0.66
comA	Streptococcus pneumoniae D39	66.246	99.582	0.66
comA	Streptococcus pneumoniae R6	66.246	99.582	0.66
comA	Streptococcus pneumoniae TIGR4	65.966	99.582	0.657
comA	Streptococcus gordonii str. Challis substr. CH1	65.686	99.582	0.654