Detailed information NTG1132360

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: H1W81_RS09075
• Genome accession: NZ_LR824002
• Coordinates: 1748729..1749628 (-)
• Length: 299 a.a.
• NCBI ID: WP_011225448.1
• Uniprot ID: Q5M612
• Organism: Streptococcus thermophilus isolate STH_CIRM_67
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 1743729..1754628

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W81_RS09035 (STHERMO_2029)	-	1743731..1744246 (-)	516	WP_002949547.1	AmiS/UreI family transporter	-
H1W81_RS09725 (STHERMO_2030)	-	1744747..1745547 (+)	801	WP_011225455.1	hypothetical protein	-
H1W81_RS09045 (STHERMO_2032)	-	1746034..1746351 (-)	318	WP_011225454.1	DUF805 domain-containing protein	-
H1W81_RS09050 (STHERMO_2033)	-	1746459..1747027 (-)	569	Protein_1729	ATP-binding cassette domain-containing protein	-
H1W81_RS09065 (STHERMO_2036)	-	1747313..1748554 (-)	1242	Protein_1730	ABC transporter transmembrane domain-containing protein	-
H1W81_RS09075 (STHERMO_2038)	comR	1748729..1749628 (-)	900	WP_011225448.1	helix-turn-helix domain-containing protein	Regulator
H1W81_RS09080 (STHERMO_2039)	-	1749834..1750484 (-)	651	WP_011225447.1	phosphatase PAP2 family protein	-
H1W81_RS09085 (STHERMO_2040)	-	1750487..1751044 (-)	558	WP_002949523.1	ECF transporter S component	-
H1W81_RS09090 (STHERMO_2041)	-	1751356..1751895 (-)	540	WP_372585740.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
H1W81_RS09095 (STHERMO_2042)	trkA	1752153..1753502 (+)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=1132360 H1W81_RS09075 WP_011225448.1 1748729..1749628(-) (comR) [Streptococcus thermophilus isolate STH_CIRM_67]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=1132360 H1W81_RS09075 WP_011225448.1 1748729..1749628(-) (comR) [Streptococcus thermophilus isolate STH_CIRM_67]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTAGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (75-292)

• Helix-turn-helix (HTH_3) (11-66)

3D structure

• AlphaFold DB: Q5M612

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	100	100	1
comR	Streptococcus thermophilus LMD-9	99.331	100	0.993
comR	Streptococcus salivarius strain HSISS4	95.318	100	0.953
comR	Streptococcus salivarius SK126	94.649	100	0.946
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421