Detailed information NTG1132165

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: H1X04_RS01480
• Genome accession: NZ_LR822043
• Coordinates: 269902..270801 (+)
• Length: 299 a.a.
• NCBI ID: WP_011225448.1
• Uniprot ID: Q5M612
• Organism: Streptococcus thermophilus isolate STH_CIRM_2101
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 264902..275801

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1X04_RS01460 (STHERMO_0284)	trkA	266028..267377 (-)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-
H1X04_RS01465 (STHERMO_0285)	-	267635..268174 (+)	540	WP_372585740.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
H1X04_RS01470 (STHERMO_0286)	-	268486..269043 (+)	558	WP_002949523.1	ECF transporter S component	-
H1X04_RS01475 (STHERMO_0287)	-	269046..269696 (+)	651	WP_011225447.1	phosphatase PAP2 family protein	-
H1X04_RS01480 (STHERMO_0288)	comR	269902..270801 (+)	900	WP_011225448.1	helix-turn-helix domain-containing protein	Regulator
H1X04_RS09315 (STHERMO_0290)	-	271039..272217 (+)	1179	Protein_239	ABC transporter transmembrane domain-containing protein	-
H1X04_RS01500 (STHERMO_0293)	-	272503..273071 (+)	569	Protein_240	ATP-binding cassette domain-containing protein	-
H1X04_RS01505 (STHERMO_0294)	-	273179..273496 (+)	318	WP_011225454.1	DUF805 domain-containing protein	-
H1X04_RS09440 (STHERMO_0297)	-	273983..274783 (-)	801	WP_011225455.1	hypothetical protein	-
H1X04_RS01515 (STHERMO_0298)	-	275284..275799 (+)	516	WP_002949547.1	AmiS/UreI family transporter	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=1132165 H1X04_RS01480 WP_011225448.1 269902..270801(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_2101]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=1132165 H1X04_RS01480 WP_011225448.1 269902..270801(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_2101]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTAGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (75-292)

• Helix-turn-helix (HTH_3) (11-66)

3D structure

• AlphaFold DB: Q5M612

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	100	100	1
comR	Streptococcus thermophilus LMD-9	99.331	100	0.993
comR	Streptococcus salivarius strain HSISS4	95.318	100	0.953
comR	Streptococcus salivarius SK126	94.649	100	0.946
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421