Detailed information
Bioinformatically predicted
Overview
| Name | stkP/pknB | Type | Regulator |
| Locus tag | H1W86_RS06530 | Genome accession | NZ_LR822042 |
| Coordinates | 1257983..1259854 (-) | Length | 623 a.a. |
| NCBI ID | WP_014621795.1 | Uniprot ID | A0A3G6JKP3 |
| Organism | Streptococcus thermophilus isolate STH_CIRM_1358 | ||
| Function | activate comX expression (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1256218..1327509 | 1257983..1259854 | within | 0 |
Gene organization within MGE regions
Location: 1256218..1327509
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H1W86_RS06520 (STHERMO_1431) | liaF | 1256226..1256924 (-) | 699 | WP_011226289.1 | cell wall-active antibiotics response protein LiaF | - |
| H1W86_RS09785 (STHERMO_1432) | - | 1257179..1257346 (-) | 168 | WP_014608530.1 | potassium channel family protein | - |
| H1W86_RS06530 (STHERMO_1435) | stkP/pknB | 1257983..1259854 (-) | 1872 | WP_014621795.1 | Stk1 family PASTA domain-containing Ser/Thr kinase | Regulator |
| H1W86_RS06535 (STHERMO_1436) | - | 1259854..1260591 (-) | 738 | WP_002946881.1 | Stp1/IreP family PP2C-type Ser/Thr phosphatase | - |
| H1W86_RS06540 (STHERMO_1437) | rsmB | 1260635..1261957 (-) | 1323 | WP_014608533.1 | 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB | - |
| H1W86_RS06545 (STHERMO_1438) | fmt | 1261947..1262882 (-) | 936 | WP_014608534.1 | methionyl-tRNA formyltransferase | - |
| H1W86_RS06550 (STHERMO_1439) | - | 1262900..1265296 (-) | 2397 | WP_134973349.1 | primosomal protein N' | - |
| H1W86_RS06555 (STHERMO_1440) | rpoZ | 1265438..1265752 (-) | 315 | WP_002951415.1 | DNA-directed RNA polymerase subunit omega | - |
| H1W86_RS06560 (STHERMO_1441) | gmk | 1265774..1266403 (-) | 630 | WP_180479475.1 | guanylate kinase | - |
| H1W86_RS06565 (STHERMO_1442) | ftsY | 1266629..1268020 (-) | 1392 | WP_180479477.1 | signal recognition particle-docking protein FtsY | - |
| H1W86_RS06570 (STHERMO_1443) | - | 1268034..1268849 (-) | 816 | WP_180473278.1 | Cof-type HAD-IIB family hydrolase | - |
| H1W86_RS06575 (STHERMO_1444) | - | 1268842..1269636 (-) | 795 | WP_180479479.1 | HAD-IIB family hydrolase | - |
| H1W86_RS06580 (STHERMO_1445) | - | 1269821..1270198 (+) | 378 | WP_011226300.1 | GntR family transcriptional regulator | - |
| H1W86_RS06585 (STHERMO_1446) | - | 1270203..1270901 (+) | 699 | WP_180479481.1 | ABC transporter ATP-binding protein | - |
| H1W86_RS06590 (STHERMO_1447) | - | 1270913..1271698 (+) | 786 | WP_180479483.1 | ABC transporter permease | - |
| H1W86_RS06595 (STHERMO_1448) | amiF | 1271748..1272677 (-) | 930 | WP_002951426.1 | ATP-binding cassette domain-containing protein | Regulator |
| H1W86_RS06600 (STHERMO_1449) | amiE | 1272670..1273755 (-) | 1086 | WP_180479485.1 | ABC transporter ATP-binding protein | Regulator |
| H1W86_RS06605 (STHERMO_1450) | amiD | 1273765..1274691 (-) | 927 | WP_002946409.1 | oligopeptide ABC transporter permease OppC | Regulator |
| H1W86_RS06610 (STHERMO_1451) | amiC | 1274691..1276184 (-) | 1494 | WP_180479487.1 | ABC transporter permease | Regulator |
| H1W86_RS06615 (STHERMO_1452) | amiA | 1276246..1278213 (-) | 1968 | WP_180479489.1 | peptide ABC transporter substrate-binding protein | Regulator |
| H1W86_RS09420 (STHERMO_1453) | - | 1278569..1279746 (+) | 1178 | Protein_1265 | ISL3 family transposase | - |
| H1W86_RS06625 (STHERMO_1454) | amiA3 | 1279791..1281764 (-) | 1974 | WP_180479491.1 | peptide ABC transporter substrate-binding protein | Regulator |
| H1W86_RS06630 (STHERMO_1456) | - | 1282069..1283216 (+) | 1148 | WP_180479467.1 | IS3 family transposase | - |
| H1W86_RS06635 | - | 1283254..1283438 (-) | 185 | Protein_1268 | IS3 family transposase | - |
| H1W86_RS09790 | - | 1283432..1283842 (-) | 411 | Protein_1269 | ATP-binding cassette domain-containing protein | - |
| H1W86_RS06650 (STHERMO_1459) | - | 1283869..1284189 (-) | 321 | Protein_1270 | TatD family hydrolase | - |
| H1W86_RS06655 (STHERMO_1460) | - | 1284536..1285741 (+) | 1206 | WP_011681420.1 | OFA family MFS transporter | - |
| H1W86_RS06660 | - | 1285787..1287100 (-) | 1314 | Protein_1272 | IS3 family transposase | - |
| H1W86_RS06665 (STHERMO_1465) | pta | 1287225..1288208 (-) | 984 | WP_011227420.1 | phosphate acetyltransferase | - |
| H1W86_RS06670 (STHERMO_1466) | - | 1288222..1289118 (-) | 897 | WP_179970626.1 | RluA family pseudouridine synthase | - |
| H1W86_RS06675 (STHERMO_1467) | - | 1289115..1289951 (-) | 837 | WP_041827075.1 | NAD kinase | - |
| H1W86_RS06680 (STHERMO_1468) | - | 1289923..1290597 (-) | 675 | WP_002951443.1 | GTP pyrophosphokinase family protein | - |
| H1W86_RS06685 (STHERMO_1469) | - | 1290693..1291268 (+) | 576 | WP_002951444.1 | CYTH domain-containing protein | - |
| H1W86_RS06690 (STHERMO_1470) | - | 1291633..1292604 (+) | 972 | WP_002951446.1 | ribose-phosphate diphosphokinase | - |
| H1W86_RS06695 (STHERMO_1471) | - | 1292608..1293720 (+) | 1113 | WP_002948029.1 | cysteine desulfurase family protein | - |
| H1W86_RS06700 (STHERMO_1472) | - | 1293722..1294069 (+) | 348 | WP_011226321.1 | DUF1831 domain-containing protein | - |
| H1W86_RS06705 (STHERMO_1473) | - | 1294214..1294873 (+) | 660 | WP_014608556.1 | redox-sensing transcriptional repressor Rex | - |
| H1W86_RS06710 (STHERMO_1474) | - | 1294866..1295561 (+) | 696 | WP_014608557.1 | gamma-glutamyl-gamma-aminobutyrate hydrolase family protein | - |
| H1W86_RS06715 (STHERMO_1475) | radC | 1295614..1296300 (-) | 687 | WP_011226324.1 | RadC family protein | - |
| H1W86_RS06720 (STHERMO_1476) | - | 1296349..1298133 (-) | 1785 | WP_014727631.1 | rhamnan synthesis F family protein | - |
| H1W86_RS06725 (STHERMO_1477) | - | 1298130..1299185 (-) | 1056 | WP_002948022.1 | glycosyltransferase family 2 protein | - |
| H1W86_RS06730 (STHERMO_1478) | - | 1299205..1300410 (-) | 1206 | WP_014727633.1 | ABC transporter ATP-binding protein | - |
| H1W86_RS06735 (STHERMO_1479) | - | 1300410..1301219 (-) | 810 | WP_002948020.1 | ABC transporter permease | - |
| H1W86_RS06740 (STHERMO_1480) | - | 1301203..1302159 (-) | 957 | WP_014727634.1 | glycosyltransferase family 2 protein | - |
| H1W86_RS06745 (STHERMO_1481) | cps2T | 1302156..1303304 (-) | 1149 | WP_002948014.1 | beta 1-4 rhamnosyltransferase Cps2T | - |
| H1W86_RS06750 (STHERMO_1482) | - | 1303413..1304423 (-) | 1011 | WP_011226330.1 | glycosyltransferase family 2 protein | - |
| H1W86_RS06755 (STHERMO_1483) | - | 1304420..1305697 (-) | 1278 | WP_014727635.1 | lipopolysaccharide biosynthesis protein | - |
| H1W86_RS06760 (STHERMO_1484) | - | 1305690..1306022 (-) | 333 | WP_011226332.1 | DUF2304 domain-containing protein | - |
| H1W86_RS06765 (STHERMO_1485) | - | 1306028..1306723 (-) | 696 | WP_171073564.1 | glycosyltransferase family 2 protein | - |
| H1W86_RS06770 (STHERMO_1486) | rfbD | 1306800..1307651 (-) | 852 | WP_014727637.1 | dTDP-4-dehydrorhamnose reductase | - |
| H1W86_RS06775 (STHERMO_1487) | - | 1307728..1309062 (-) | 1335 | WP_180479493.1 | DUF6056 family protein | - |
| H1W86_RS06780 (STHERMO_1488) | - | 1309175..1310092 (-) | 918 | WP_002946425.1 | glycosyltransferase family 2 protein | - |
| H1W86_RS06785 (STHERMO_1489) | - | 1310155..1311570 (-) | 1416 | WP_014727640.1 | DUF2142 domain-containing protein | - |
| H1W86_RS06790 (STHERMO_1491) | - | 1311904..1312239 (-) | 336 | WP_002891474.1 | metal-sulfur cluster assembly factor | - |
| H1W86_RS06795 (STHERMO_1492) | rpoD | 1312293..1313402 (-) | 1110 | WP_180479495.1 | RNA polymerase sigma factor RpoD | - |
| H1W86_RS06800 (STHERMO_1493) | dnaG | 1313406..1315217 (-) | 1812 | WP_116920323.1 | DNA primase | - |
| H1W86_RS06805 (STHERMO_1494) | rpsU | 1315588..1315764 (-) | 177 | WP_082309068.1 | 30S ribosomal protein S21 | - |
| H1W86_RS06810 (STHERMO_1495) | - | 1315959..1316753 (-) | 795 | WP_023909836.1 | ABC transporter substrate-binding protein | - |
| H1W86_RS06815 (STHERMO_1496) | - | 1316846..1317955 (-) | 1110 | WP_180479732.1 | aminotransferase | - |
| H1W86_RS06820 (STHERMO_1497) | - | 1318302..1319099 (-) | 798 | WP_082309071.1 | transporter substrate-binding domain-containing protein | - |
| H1W86_RS06825 (STHERMO_1498) | - | 1319096..1319926 (-) | 831 | WP_022097022.1 | transporter substrate-binding domain-containing protein | - |
| H1W86_RS06830 (STHERMO_1499) | - | 1320140..1320604 (-) | 465 | WP_011681454.1 | 8-oxo-dGTP diphosphatase | - |
| H1W86_RS06835 (STHERMO_1500) | uvrB | 1320649..1322640 (-) | 1992 | WP_002953358.1 | excinuclease ABC subunit UvrB | - |
| H1W86_RS06840 | - | 1323327..1324263 (-) | 937 | Protein_1308 | CPBP family intramembrane glutamic endopeptidase | - |
| H1W86_RS06845 (STHERMO_1505) | - | 1324461..1326671 (+) | 2211 | WP_179970611.1 | ABC transporter substrate-binding protein/permease | - |
| H1W86_RS06850 (STHERMO_1506) | - | 1326671..1327411 (+) | 741 | WP_011681459.1 | amino acid ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 623 a.a. Molecular weight: 67847.64 Da Isoelectric Point: 6.9480
>NTDB_id=1132127 H1W86_RS06530 WP_014621795.1 1257983..1259854(-) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_1358]
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNESVAIKVLRTNYQTDQVAVARFQREARAMTELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLHPSHSRDSKVVFDDMTDAKTLPKVDSVSSVGPEKKISPKPSEPTPAP
SKQPREKASLSKKKKNLFSTLLKVLLGFVFIGIIIFAYLVFTNPDNVQVPNVVGQELSTAQTKLESAGFKVGDVKEVEND
SVNKGKVIKTDPTAGTMRKEGASIDVYVSSGSKGFTLKNYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDNAKEGEILS
QSSEKNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNSKDISSSSIEYHDYNTGVKLDKSKVPSNTEVLYQ
DPQVGTAVDGTVILYVSVVTKSSSIQQSSSASTTQSSSSTSSSSESSTASSTETATEATHTEQ
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNESVAIKVLRTNYQTDQVAVARFQREARAMTELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLHPSHSRDSKVVFDDMTDAKTLPKVDSVSSVGPEKKISPKPSEPTPAP
SKQPREKASLSKKKKNLFSTLLKVLLGFVFIGIIIFAYLVFTNPDNVQVPNVVGQELSTAQTKLESAGFKVGDVKEVEND
SVNKGKVIKTDPTAGTMRKEGASIDVYVSSGSKGFTLKNYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDNAKEGEILS
QSSEKNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNSKDISSSSIEYHDYNTGVKLDKSKVPSNTEVLYQ
DPQVGTAVDGTVILYVSVVTKSSSIQQSSSASTTQSSSSTSSSSESSTASSTETATEATHTEQ
Nucleotide
Download Length: 1872 bp
>NTDB_id=1132127 H1W86_RS06530 WP_014621795.1 1257983..1259854(-) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_1358]
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAGTGTAGCTATTAAGGTACTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCACGTGCCATGACTGAGCTTAGCCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCAGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCTAACCAAGATGTTGTGCGTATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAACCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGTAACTAGTTTGCATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATGCTAAGACCC
TGCCAAAGGTTGATTCAGTTTCATCAGTAGGTCCTGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTACACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAAAAGAAAAATCTCTTTTCAACTCTACTCAAGGTTTTACTAGG
CTTCGTCTTTATAGGAATTATCATTTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAGTTGTCAACAGCTCAGACGAAACTTGAAAGTGCAGGCTTTAAGGTTGGCGATGTTAAAGAAGTCGAAAATGAT
TCAGTCAATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAATGCGTAAAGAGGGAGCAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACAAGGGGAAAAATTATAAGGATGCCATTGAGGATTTAACCT
CGAATTATGGGGTTTCCGAGGATCAGATCGATATTCAACATGTCGAAGACGATAATGCTAAAGAAGGCGAAATTCTATCT
CAAAGTTCGGAGAAAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
TATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATAGTAAAGACATTTCAAGCAGCA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACAGAGGTCCTTTATCAA
GATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTAAGAGTTCAAGTATTCAACA
GTCAAGCTCAGCAAGTACGACACAATCGTCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAGTGTAGCTATTAAGGTACTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCACGTGCCATGACTGAGCTTAGCCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCAGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCTAACCAAGATGTTGTGCGTATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAACCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGTAACTAGTTTGCATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATGCTAAGACCC
TGCCAAAGGTTGATTCAGTTTCATCAGTAGGTCCTGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTACACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAAAAGAAAAATCTCTTTTCAACTCTACTCAAGGTTTTACTAGG
CTTCGTCTTTATAGGAATTATCATTTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAGTTGTCAACAGCTCAGACGAAACTTGAAAGTGCAGGCTTTAAGGTTGGCGATGTTAAAGAAGTCGAAAATGAT
TCAGTCAATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAATGCGTAAAGAGGGAGCAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACAAGGGGAAAAATTATAAGGATGCCATTGAGGATTTAACCT
CGAATTATGGGGTTTCCGAGGATCAGATCGATATTCAACATGTCGAAGACGATAATGCTAAAGAAGGCGAAATTCTATCT
CAAAGTTCGGAGAAAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
TATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATAGTAAAGACATTTCAAGCAGCA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACAGAGGTCCTTTATCAA
GATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTAAGAGTTCAAGTATTCAACA
GTCAAGCTCAGCAAGTACGACACAATCGTCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| stkP/pknB | Streptococcus salivarius strain HSISS4 |
90.534 |
93.258 |
0.844 |
| pknB | Streptococcus mutans UA159 |
64.522 |
87.319 |
0.563 |
| stkP | Streptococcus pneumoniae TIGR4 |
56.713 |
80.096 |
0.454 |
| stkP | Streptococcus pneumoniae D39 |
56.513 |
80.096 |
0.453 |
| stkP | Streptococcus pneumoniae R6 |
56.513 |
80.096 |
0.453 |
| stkP | Streptococcus pneumoniae Rx1 |
56.313 |
80.096 |
0.451 |