Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   H1W94_RS01475 Genome accession   NZ_LR822041
Coordinates   271177..272076 (+) Length   299 a.a.
NCBI ID   WP_156703476.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_1122     
Function   activate transcription of comX; activate transcription of comS (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 260228..274347 271177..272076 within 0


Gene organization within MGE regions


Location: 260228..274347
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W94_RS01410 (STHERMO_0285) xerD 260240..261001 (+) 762 WP_011225439.1 site-specific tyrosine recombinase XerD -
  H1W94_RS01415 (STHERMO_0286) - 261001..261714 (+) 714 WP_011226851.1 segregation/condensation protein A -
  H1W94_RS01420 (STHERMO_0287) scpB 261707..262288 (+) 582 WP_011226852.1 SMC-Scp complex subunit ScpB -
  H1W94_RS01425 (STHERMO_0288) - 262381..263106 (+) 726 WP_002949498.1 pseudouridine synthase -
  H1W94_RS01430 (STHERMO_0289) yidD 263103..263354 (+) 252 WP_011225443.1 membrane protein insertion efficiency factor YidD -
  H1W94_RS01435 (STHERMO_0290) - 263377..264816 (-) 1440 WP_002949500.1 TrkH family potassium uptake protein -
  H1W94_RS01440 (STHERMO_0291) - 264823..265005 (-) 183 Protein_236 TrkA C-terminal domain-containing protein -
  H1W94_RS01445 (STHERMO_0292) - 265025..265978 (-) 954 WP_041826943.1 IS30 family transposase -
  H1W94_RS01450 (STHERMO_0293) trkA 266110..267417 (-) 1308 WP_232087300.1 Trk system potassium transporter TrkA -
  H1W94_RS01455 (STHERMO_0294) - 267603..268556 (-) 954 WP_041826943.1 IS30 family transposase -
  H1W94_RS01460 (STHERMO_0295) - 268921..269460 (+) 540 WP_372585740.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
  H1W94_RS01465 (STHERMO_0296) - 269772..270329 (+) 558 WP_002949523.1 ECF transporter S component -
  H1W94_RS01470 (STHERMO_0297) - 270332..270982 (+) 651 WP_011226853.1 phosphatase PAP2 family protein -
  H1W94_RS01475 (STHERMO_0298) comR 271177..272076 (+) 900 WP_156703476.1 helix-turn-helix domain-containing protein Regulator
  H1W94_RS09595 - 272315..273493 (+) 1179 Protein_244 ABC transporter transmembrane domain-containing protein -
  H1W94_RS01495 (STHERMO_0303) - 273779..274347 (+) 569 Protein_245 ATP-binding cassette domain-containing protein -

Sequence

Protein


Download         Length: 299 a.a.        Molecular weight: 35345.85 Da        Isoelectric Point: 5.1073

>NTDB_id=1132045 H1W94_RS01475 WP_156703476.1 271177..272076(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_1122]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLIIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAVENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide


Download         Length: 900 bp        

>NTDB_id=1132045 H1W94_RS01475 WP_156703476.1 271177..272076(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_1122]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAATCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGTAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(11-66)

ComR tetratricopeptide (ComR_TPR)

(75-292)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus thermophilus LMG 18311

99.331

100

0.993
  comR Streptococcus thermophilus LMD-9

98.662

100

0.987
  comR Streptococcus salivarius strain HSISS4

94.649

100

0.946
  comR Streptococcus salivarius SK126

93.98

100

0.94
  comR/comR1 Streptococcus sobrinus strain NIDR 6715-7

42.14

100

0.421
  comR/comR2 Streptococcus sobrinus strain NIDR 6715-7

42.14

100

0.421

Multiple sequence alignment