Detailed information NTG1131887

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: H1W87_RS05450
• Genome accession: NZ_LR822037
• Coordinates: 1028827..1029534 (-)
• Length: 235 a.a.
• NCBI ID: WP_173940375.1
• Uniprot ID: A0A2H4K9R7
• Organism: Streptococcus thermophilus isolate STH_CIRM_1121
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1023827..1034534

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W87_RS05425 (STHERMO_1208)	yidA	1024178..1024987 (+)	810	WP_011226081.1	sugar-phosphatase	-
H1W87_RS05430 (STHERMO_1209)	-	1024989..1026203 (+)	1215	WP_179966654.1	aminoacyltransferase	-
H1W87_RS05435	-	1026255..1026616 (-)	362	Protein_1012	YbaN family protein	-
H1W87_RS05440 (STHERMO_1210)	vicX	1026676..1027488 (-)	813	WP_011681204.1	MBL fold metallo-hydrolase	Regulator
H1W87_RS05445 (STHERMO_1211)	vicK	1027494..1028834 (-)	1341	WP_011227273.1	cell wall metabolism sensor histidine kinase VicK	Regulator
H1W87_RS05450 (STHERMO_1212)	vicR	1028827..1029534 (-)	708	WP_173940375.1	response regulator YycF	Regulator
H1W87_RS05455 (STHERMO_1214)	-	1030059..1030826 (+)	768	WP_179966655.1	amino acid ABC transporter ATP-binding protein	-
H1W87_RS05460 (STHERMO_1215)	-	1030838..1031671 (+)	834	WP_002953142.1	transporter substrate-binding domain-containing protein	-
H1W87_RS05465 (STHERMO_1216)	-	1031689..1032387 (+)	699	WP_011226087.1	amino acid ABC transporter permease	-
H1W87_RS05470 (STHERMO_1217)	-	1032399..1033049 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
H1W87_RS05475 (STHERMO_1218)	endA	1033121..1034002 (-)	882	WP_022096754.1	DNA/RNA non-specific endonuclease	Machinery gene
H1W87_RS05480 (STHERMO_1219)	-	1034064..1034252 (-)	189	WP_176243147.1	DNA-directed RNA polymerase subunit beta	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27087.04 Da
• Isoelectric Point: 5.0130

>NTDB_id=1131887 H1W87_RS05450 WP_173940375.1 1028827..1029534(-) (vicR) [Streptococcus thermophilus isolate STH_CIRM_1121]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEIAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=1131887 H1W87_RS05450 WP_173940375.1 1028827..1029534(-) (vicR) [Streptococcus thermophilus isolate STH_CIRM_1121]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCTGAACTGGATGGTTTGGAAATTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACTGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCATCGTGAATTTGAGTTACTCTTCCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterProScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

• Response regulator receiver domain (Response_reg) (4-113)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.106	100	0.851
micA	Streptococcus pneumoniae Cp1015	79.828	99.149	0.791
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.455	98.298	0.447
covR	Streptococcus salivarius strain HSISS4	44.872	99.574	0.447
scnR	Streptococcus mutans UA159	38.136	100	0.383