Detailed information NTG1131657

Bioinformatically predicted

Overview

• Name: comEA
• Type: Machinery gene
• Locus tag: H1W90_RS07385
• Genome accession: NZ_LR822033
• Coordinates: 1437645..1438340 (-)
• Length: 231 a.a.
• NCBI ID: WP_082309090.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus isolate STH_CIRM_1048
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1432645..1443340

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W90_RS07370 (STHERMO_1644)	-	1433456..1434001 (-)	546	WP_022096992.1	GNAT family N-acetyltransferase	-
H1W90_RS07375 (STHERMO_1645)	-	1434067..1435329 (-)	1263	WP_022096991.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
H1W90_RS07380 (STHERMO_1646)	-	1435415..1437655 (-)	2241	WP_180481070.1	DNA internalization-related competence protein ComEC/Rec2	-
H1W90_RS07385 (STHERMO_1647)	comEA	1437645..1438340 (-)	696	WP_082309090.1	helix-hairpin-helix domain-containing protein	Machinery gene
H1W90_RS07390 (STHERMO_1648)	-	1438448..1439203 (-)	756	WP_002948862.1	lysophospholipid acyltransferase family protein	-
H1W90_RS10515 (STHERMO_1649)	-	1439403..1439936 (+)	534	WP_084829791.1	polysaccharide deacetylase family protein	-
H1W90_RS10120 (STHERMO_1650)	-	1439870..1440259 (+)	390	WP_288217394.1	peptidoglycan GlcNAc deacetylase	-
H1W90_RS07400 (STHERMO_1651)	-	1440275..1441531 (-)	1257	Protein_1425	ISL3-like element ISSth1 family transposase	-
H1W90_RS07405 (STHERMO_1653)	-	1441742..1442494 (+)	753	WP_002948852.1	tRNA1(Val) (adenine(37)-N6)-methyltransferase	-
H1W90_RS07410 (STHERMO_1654)	-	1442511..1442780 (+)	270	WP_002948849.1	GIY-YIG nuclease family protein	-

Sequence

Protein

• Length: 231 a.a.
• Molecular weight: 24514.46 Da
• Isoelectric Point: 4.6300

>NTDB_id=1131657 H1W90_RS07385 WP_082309090.1 1437645..1438340(-) (comEA) [Streptococcus thermophilus isolate STH_CIRM_1048]
MKEKILAYVKDNRLFVSVIAVLMVIFCFFLWMTCGAGNSMEAETSYTDVTALSTSSSKQSSQSLSEASSQSKTEGSEKVK
SKVTVDVKGAVVNPGVYTLKAGARVTDVIQEAGGMTEDADAKSVNLAASLSDEEVIYVANKDENVSVLDQTGTGQVSDKG
GQAVSKDGKINLNTATSEQLQTISGIGAKRTEDIIAYRESHGGFQSVDDLKNVSGIGDKTLDKIRESLYVA

Nucleotide

• Length: 696 bp

>NTDB_id=1131657 H1W90_RS07385 WP_082309090.1 1437645..1438340(-) (comEA) [Streptococcus thermophilus isolate STH_CIRM_1048]
GTGAAGGAAAAGATTCTAGCCTATGTCAAAGATAATCGTCTGTTTGTGAGTGTCATCGCTGTACTGATGGTGATTTTTTG
CTTCTTTTTATGGATGACTTGTGGTGCCGGCAACAGCATGGAGGCGGAGACGTCTTATACAGATGTGACAGCTTTGTCAA
CGTCTTCATCCAAACAAAGTTCACAGTCTCTTTCTGAGGCGTCTTCCCAGTCAAAGACCGAAGGAAGTGAAAAAGTTAAG
TCAAAAGTAACGGTAGATGTTAAGGGGGCTGTGGTCAATCCAGGTGTCTATACGCTAAAGGCAGGCGCTAGGGTGACAGA
TGTCATTCAGGAAGCTGGAGGAATGACAGAAGATGCAGACGCTAAGAGTGTTAACTTAGCCGCAAGCTTGTCAGATGAAG
AGGTTATTTATGTAGCCAATAAAGATGAAAATGTTTCTGTCCTTGATCAAACAGGTACTGGTCAGGTCTCTGACAAAGGA
GGGCAGGCTGTATCTAAGGATGGCAAAATTAACTTAAATACAGCAACCTCAGAGCAGTTGCAAACCATTTCTGGAATTGG
AGCTAAGCGGACAGAGGATATCATTGCCTATCGTGAAAGTCATGGCGGCTTTCAGTCCGTAGATGACTTGAAAAATGTCT
CAGGAATTGGTGATAAAACATTAGATAAAATCAGAGAGTCCCTCTATGTGGCTTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (85-138)

• Helix-hairpin-helix motif (HHH_3) (167-228)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA	Streptococcus thermophilus LMD-9	99.134	100	0.991
comEA/celA/cilE	Streptococcus mitis SK321	40.611	99.134	0.403
comEA/celA/cilE	Streptococcus pneumoniae D39	39.035	98.701	0.385
comEA/celA/cilE	Streptococcus pneumoniae R6	39.035	98.701	0.385
comEA/celA/cilE	Streptococcus pneumoniae Rx1	39.035	98.701	0.385
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	39.035	98.701	0.385
comEA/celA/cilE	Streptococcus mitis NCTC 12261	37.719	98.701	0.372