Detailed information NTG1131646

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: H1W90_RS05500
• Genome accession: NZ_LR822033
• Coordinates: 1053863..1054570 (-)
• Length: 235 a.a.
• NCBI ID: WP_011226084.1
• Uniprot ID: A0A060BQ44
• Organism: Streptococcus thermophilus isolate STH_CIRM_1048
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1048863..1059570

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W90_RS05475 (STHERMO_1222)	yidA	1049214..1050023 (+)	810	WP_011226081.1	sugar-phosphatase	-
H1W90_RS05480 (STHERMO_1223)	-	1050025..1051239 (+)	1215	WP_011227270.1	aminoacyltransferase	-
H1W90_RS05485 (STHERMO_1224)	-	1051291..1051652 (-)	362	Protein_1043	YbaN family protein	-
H1W90_RS05490 (STHERMO_1225)	vicX	1051712..1052524 (-)	813	WP_011681204.1	MBL fold metallo-hydrolase	Regulator
H1W90_RS05495 (STHERMO_1226)	vicK	1052530..1053870 (-)	1341	WP_011227273.1	cell wall metabolism sensor histidine kinase VicK	Regulator
H1W90_RS05500 (STHERMO_1227)	vicR	1053863..1054570 (-)	708	WP_011226084.1	response regulator YycF	Regulator
H1W90_RS05505 (STHERMO_1228)	-	1055094..1055861 (+)	768	WP_179966655.1	amino acid ABC transporter ATP-binding protein	-
H1W90_RS05510 (STHERMO_1229)	-	1055873..1056706 (+)	834	WP_002953142.1	transporter substrate-binding domain-containing protein	-
H1W90_RS05515 (STHERMO_1230)	-	1056724..1057422 (+)	699	WP_011226087.1	amino acid ABC transporter permease	-
H1W90_RS05520 (STHERMO_1231)	-	1057434..1058084 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
H1W90_RS05525 (STHERMO_1232)	endA	1058155..1059036 (-)	882	WP_011681210.1	DNA/RNA non-specific endonuclease	Machinery gene
H1W90_RS05530 (STHERMO_1233)	-	1059098..1059286 (-)	189	WP_002953149.1	DNA-directed RNA polymerase subunit beta	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27073.01 Da
• Isoelectric Point: 5.0130

>NTDB_id=1131646 H1W90_RS05500 WP_011226084.1 1053863..1054570(-) (vicR) [Streptococcus thermophilus isolate STH_CIRM_1048]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEVAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=1131646 H1W90_RS05500 WP_011226084.1 1053863..1054570(-) (vicR) [Streptococcus thermophilus isolate STH_CIRM_1048]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAGCAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCTGAACTGGATGGTTTGGAAGTTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACTGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTAATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCATCGTGAATTTGAGTTACTCTTCCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-113)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

3D structure

• AlphaFold DB: A0A060BQ44

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.532	100	0.855
micA	Streptococcus pneumoniae Cp1015	80.258	99.149	0.796
covR	Streptococcus salivarius strain HSISS4	45.299	99.574	0.451
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.887	98.298	0.451
scnR	Streptococcus mutans UA159	38.559	100	0.387