Detailed information NTG1131583

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: H1W91_RS04665
• Genome accession: NZ_LR822032
• Coordinates: 881788..882513 (+)
• Length: 241 a.a.
• NCBI ID: WP_179972946.1
• Uniprot ID: A0A7U7H0X6
• Organism: Streptococcus thermophilus isolate STH_CIRM_1050
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 876788..887513

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W91_RS04630 (STHERMO_1003)	-	876880..877062 (+)	183	WP_006531883.1	Blp family class II bacteriocin	-
H1W91_RS04635 (STHERMO_1004)	-	877679..877909 (+)	231	WP_043878356.1	bacteriocin	-
H1W91_RS04640 (STHERMO_1005)	-	877998..878309 (+)	312	WP_003066586.1	hypothetical protein	-
H1W91_RS04645	-	878523..878615 (+)	93	Protein_861	Blp family class II bacteriocin	-
H1W91_RS04650 (STHERMO_1006)	-	878673..879071 (+)	399	WP_232087080.1	immunity protein	-
H1W91_RS04655 (STHERMO_1007)	-	879259..880305 (+)	1047	WP_095559358.1	thioredoxin fold domain-containing protein	-
H1W91_RS04660 (STHERMO_1008)	-	880837..881601 (+)	765	WP_232086163.1	DUF6261 family protein	-
H1W91_RS04665 (STHERMO_1009)	comE/comE1	881788..882513 (+)	726	WP_179972946.1	LytR/AlgR family response regulator transcription factor	Regulator
H1W91_RS04670 (STHERMO_1010)	-	882526..883845 (+)	1320	WP_095559360.1	sensor histidine kinase	-
H1W91_RS04675 (STHERMO_1011)	-	883866..884015 (-)	150	WP_006531893.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
H1W91_RS04685 (STHERMO_1012)	-	884542..885126 (+)	585	WP_232086162.1	hypothetical protein	-
H1W91_RS04690 (STHERMO_1013)	csm6	885141..886427 (+)	1287	WP_180476961.1	type III-A CRISPR-associated CARF protein Csm6	-
H1W91_RS04695 (STHERMO_1014)	pyrF	886627..887322 (+)	696	WP_011227188.1	orotidine-5'-phosphate decarboxylase	-

Sequence

Protein

• Length: 241 a.a.
• Molecular weight: 28020.99 Da
• Isoelectric Point: 5.2156

>NTDB_id=1131583 H1W91_RS04665 WP_179972946.1 881788..882513(+) (comE/comE1) [Streptococcus thermophilus isolate STH_CIRM_1050]
MDIFVLEDDIPQQFRMERAINLVMESNNWHYRYLEISSNPDEIIAVAGNGEHQIFFLDLEIKGEEQQGIDVAKAIREKNS
TAIIVFVTTHSEFMLLTYQSLVGAIDFIDKGLNEEAFNERLFVCLKEAVKRQEGNFGEHSYLFHTPQAKVRVAYDDILFF
ETSPAPHRIILHTKNERTEFYATIAEVAKSDERLFRCHRSFVVNVDNIARFDMRYKLIYFEMGETCPVARAKVKLLQEKI
G

Nucleotide

• Length: 726 bp

>NTDB_id=1131583 H1W91_RS04665 WP_179972946.1 881788..882513(+) (comE/comE1) [Streptococcus thermophilus isolate STH_CIRM_1050]
GTGGATATTTTTGTACTCGAAGATGATATTCCCCAACAATTCCGAATGGAGCGTGCTATTAATCTTGTGATGGAATCAAA
TAACTGGCATTATCGGTATTTGGAGATTTCATCTAATCCTGATGAAATCATCGCAGTAGCAGGTAATGGTGAACATCAAA
TTTTCTTTCTTGATTTAGAAATTAAAGGTGAAGAGCAGCAAGGGATTGATGTTGCTAAAGCTATTCGTGAAAAAAATAGC
ACAGCTATTATTGTTTTTGTGACGACACATTCTGAATTCATGCTCTTAACCTATCAATCTTTAGTAGGTGCTATTGACTT
TATTGACAAAGGATTAAACGAAGAAGCGTTTAATGAACGCTTATTCGTTTGTCTTAAAGAAGCTGTCAAACGCCAAGAGG
GAAACTTTGGTGAACATTCCTACTTGTTTCATACCCCACAAGCCAAAGTGCGGGTAGCTTATGATGATATTTTATTTTTT
GAAACGTCACCAGCACCTCATCGTATTATTTTGCACACTAAGAACGAACGTACAGAATTTTATGCGACCATAGCAGAAGT
GGCAAAATCAGATGAACGTCTTTTTAGATGTCATCGTTCTTTTGTGGTTAACGTGGATAATATCGCTAGATTTGATATGA
GGTATAAGCTCATTTATTTTGAGATGGGAGAAACCTGTCCTGTAGCTAGGGCTAAGGTGAAATTATTACAGGAGAAAATT
GGATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-120)

• LytTr DNA-binding domain (LytTR) (150-240)

3D structure

• AlphaFold DB: A0A7U7H0X6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	65.823	98.34	0.647
comE/blpR	Streptococcus mutans UA159	46.091	100	0.465
comE/comE2	Streptococcus equinus JB1	44.167	99.585	0.44
comE/comE2	Streptococcus gordonii strain NCTC7865	35.06	100	0.365
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.06	100	0.365
agrA	Staphylococcus aureus N315	35.656	100	0.361