Detailed information NTG1131565

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: H1W91_RS01485
• Genome accession: NZ_LR822032
• Coordinates: 267373..268272 (+)
• Length: 299 a.a.
• NCBI ID: WP_014607953.1
• Uniprot ID: A0AAN1ZWJ0
• Organism: Streptococcus thermophilus isolate STH_CIRM_1050
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 262373..273272

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W91_RS01465 (STHERMO_0292)	trkA	263510..264859 (-)	1350	WP_014607951.1	Trk system potassium transporter TrkA	-
H1W91_RS01470 (STHERMO_0293)	-	265118..265657 (+)	540	WP_372585740.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
H1W91_RS01475 (STHERMO_0294)	-	265968..266525 (+)	558	WP_002949523.1	ECF transporter S component	-
H1W91_RS01480 (STHERMO_0295)	-	266528..267178 (+)	651	WP_180476745.1	phosphatase PAP2 family protein	-
H1W91_RS01485 (STHERMO_0296)	comR	267373..268272 (+)	900	WP_014607953.1	helix-turn-helix domain-containing protein	Regulator
H1W91_RS09790	-	268447..269571 (+)	1125	Protein_240	cysteine peptidase family C39 domain-containing protein	-
H1W91_RS01505 (STHERMO_0302)	-	269725..270543 (+)	819	Protein_241	ATP-binding cassette domain-containing protein	-
H1W91_RS01510 (STHERMO_0303)	-	270738..270965 (+)	228	WP_232087121.1	DUF805 domain-containing protein	-
H1W91_RS09800 (STHERMO_0305)	-	271186..271533 (-)	348	WP_232087040.1	DUF4153 domain-containing protein	-
H1W91_RS09805 (STHERMO_0307)	-	271992..272363 (-)	372	WP_232087042.1	hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35289.70 Da
• Isoelectric Point: 5.0061

>NTDB_id=1131565 H1W91_RS01485 WP_014607953.1 267373..268272(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_1050]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIENS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=1131565 H1W91_RS01485 WP_014607953.1 267373..268272(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_1050]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAACTCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-292)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	99.666	100	0.997
comR	Streptococcus thermophilus LMD-9	98.997	100	0.99
comR	Streptococcus salivarius strain HSISS4	94.983	100	0.95
comR	Streptococcus salivarius SK126	94.314	100	0.943
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	41.806	100	0.418