Detailed information NTG1131346

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: H1X63_RS04990
• Genome accession: NZ_LR822027
• Coordinates: 943110..943835 (+)
• Length: 241 a.a.
• NCBI ID: WP_179972946.1
• Uniprot ID: A0A7U7H0X6
• Organism: Streptococcus thermophilus isolate STH_CIRM_998
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 938110..948835

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1X63_RS04955 (STHERMO_1057)	-	938327..938509 (+)	183	WP_006531883.1	Blp family class II bacteriocin	-
H1X63_RS04960 (STHERMO_1058)	-	939126..939356 (+)	231	WP_043878356.1	bacteriocin	-
H1X63_RS04965 (STHERMO_1059)	-	939445..939756 (+)	312	WP_003066586.1	hypothetical protein	-
H1X63_RS04970	-	939970..940062 (+)	93	Protein_930	Blp family class II bacteriocin	-
H1X63_RS04975 (STHERMO_1060)	-	940120..940524 (+)	405	WP_015695682.1	hypothetical protein	-
H1X63_RS04980 (STHERMO_1061)	-	940705..941628 (+)	924	WP_180487807.1	LPXTG cell wall anchor domain-containing protein	-
H1X63_RS04985 (STHERMO_1062)	-	942189..942923 (+)	735	WP_232086883.1	DUF6261 family protein	-
H1X63_RS04990 (STHERMO_1063)	comE/comE1	943110..943835 (+)	726	WP_179972946.1	LytR/AlgR family response regulator transcription factor	Regulator
H1X63_RS04995 (STHERMO_1064)	-	943848..945167 (+)	1320	WP_180487808.1	sensor histidine kinase	-
H1X63_RS05000 (STHERMO_1065)	-	945188..945337 (-)	150	WP_006531893.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
H1X63_RS05010 (STHERMO_1066)	-	945864..946448 (+)	585	WP_232086162.1	hypothetical protein	-
H1X63_RS05015 (STHERMO_1067)	csm6	946463..947554 (+)	1092	WP_101415612.1	type III-A CRISPR-associated CARF protein Csm6	-
H1X63_RS05020 (STHERMO_1068)	pyrF	947755..948450 (+)	696	WP_011681116.1	orotidine-5'-phosphate decarboxylase	-

Sequence

Protein

• Length: 241 a.a.
• Molecular weight: 28020.99 Da
• Isoelectric Point: 5.2156

>NTDB_id=1131346 H1X63_RS04990 WP_179972946.1 943110..943835(+) (comE/comE1) [Streptococcus thermophilus isolate STH_CIRM_998]
MDIFVLEDDIPQQFRMERAINLVMESNNWHYRYLEISSNPDEIIAVAGNGEHQIFFLDLEIKGEEQQGIDVAKAIREKNS
TAIIVFVTTHSEFMLLTYQSLVGAIDFIDKGLNEEAFNERLFVCLKEAVKRQEGNFGEHSYLFHTPQAKVRVAYDDILFF
ETSPAPHRIILHTKNERTEFYATIAEVAKSDERLFRCHRSFVVNVDNIARFDMRYKLIYFEMGETCPVARAKVKLLQEKI
G

Nucleotide

• Length: 726 bp

>NTDB_id=1131346 H1X63_RS04990 WP_179972946.1 943110..943835(+) (comE/comE1) [Streptococcus thermophilus isolate STH_CIRM_998]
GTGGATATTTTTGTACTCGAAGATGATATTCCCCAACAATTCCGAATGGAGCGTGCTATTAATCTTGTGATGGAATCAAA
TAACTGGCATTATCGGTATTTGGAGATTTCATCTAATCCTGATGAAATCATCGCAGTAGCAGGTAATGGTGAACATCAAA
TTTTCTTTCTTGATTTAGAAATTAAAGGTGAAGAGCAGCAAGGGATTGATGTTGCTAAAGCTATTCGTGAAAAAAATAGC
ACAGCTATTATTGTTTTTGTGACGACACATTCTGAATTCATGCTCTTAACCTATCAATCTTTAGTAGGTGCTATTGACTT
TATTGACAAAGGATTAAACGAAGAAGCGTTTAATGAACGCTTATTCGTTTGTCTTAAAGAAGCTGTCAAACGCCAAGAGG
GAAACTTTGGTGAACATTCCTACTTGTTTCATACCCCACAAGCCAAAGTGCGGGTAGCTTATGATGATATTTTATTTTTT
GAAACGTCACCAGCACCTCATCGTATTATTTTGCACACTAAGAACGAACGTACAGAATTTTATGCGACCATAGCAGAAGT
GGCAAAATCAGATGAACGTCTTTTTAGATGTCATCGTTCTTTTGTGGTTAACGTGGATAATATCGCTAGATTTGATATGA
GGTATAAGCTCATTTATTTTGAGATGGGAGAAACCTGTCCTGTAGCTAGGGCTAAGGTGAAATTATTACAGGAGAAAATT
GGATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-120)

• LytTr DNA-binding domain (LytTR) (150-240)

3D structure

• AlphaFold DB: A0A7U7H0X6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	65.823	98.34	0.647
comE/blpR	Streptococcus mutans UA159	46.091	100	0.465
comE/comE2	Streptococcus equinus JB1	44.167	99.585	0.44
comE/comE2	Streptococcus gordonii strain NCTC7865	35.06	100	0.365
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.06	100	0.365
agrA	Staphylococcus aureus N315	35.656	100	0.361